Zobrazeno 1 - 10 of 79 pro vyhledávání: '"Sheryl R, Tripp"'
1
Akademický článek
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
Autor: Jacob M Winter, Heidi L Fresenius, Corey N Cunningham, Peng Wei, Heather R Keys, Jordan Berg, Alex Bott, Tarun Yadav, Jeremy Ryan, Deepika Sirohi, Sheryl R Tripp, Paige Barta, Neeraj Agarwal, Anthony Letai, David M Sabatini, Matthew L Wohlever, Jared Rutter
Publikováno v: eLife, Vol 11 (2022)
The tumor suppressor gene PTEN is the second most commonly deleted gene in cancer. Such deletions often include portions of the chromosome 10q23 locus beyond the bounds of PTEN itself, which frequently disrupts adjacent genes. Coincidental loss of PT
Externí odkaz: https://doaj.org/article/2668821f2b48436287366923def05d35
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2
Akademický článek
Mutant IDH1 Promotes Glioma Formation In Vivo
Autor: Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen
Publikováno v: Cell Reports, Vol 23, Iss 5, Pp 1553-1564 (2018)
Summary: Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1R132H in gliomagenesis has been proposed, but functional validation in vivo has not been dem
Externí odkaz: https://doaj.org/article/2d92767aaa004267a8ec8cf27e3f8ef6
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3
ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma
Autor: Yangsook Song Green, Maria C. Ferreira dos Santos, Daniel G. Fuja, Ethan C. Reichert, Alexandre R. Campos, Sophie J. Cowman, Karen Acuña Pilarte, Jessica Kohan, Sheryl R. Tripp, Elizabeth A. Leibold, Deepika Sirohi, Neeraj Agarwal, Xiaohui Liu, Mei Yee Koh
Publikováno v: Oncogene. 41:4709-4723
Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is typically initiated by inactivation of the von Hippel Lindau (VHL) gene, which results in the constitutive activation of the hypoxia inducible factors, HIF-1α and HIF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::045886adf9ce9ea8f76758d6455ee9cb
https://doi.org/10.1038/s41388-022-02460-1
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8
Akademický článek
SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.
Autor: Lei L Chen, Jing Zhu, Jonathan Schumacher, Chongjuan Wei, Latha Ramdas, Victor G Prieto, Arnie Jimenez, Marco A Velasco, Sheryl R Tripp, Robert H I Andtbacka, Launce Gouw, George M Rodgers, Liansheng Zhang, Benjamin K Chan, Pamela B Cassidy, Robert S Benjamin, Sancy A Leachman, Marsha L Frazier
Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184154 (2017)
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human
Externí odkaz: https://doaj.org/article/46dfaee1e3fc43939d5e87e4ff5f3493
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