Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Sheryl E, Koch"'
Autor:
Darshini A. Desai, Akhil Baby, Kalyani Ananthamohan, Lisa C. Green, Mohammed Arif, Brittany C. Duncan, Mohit Kumar, Rohit R. Singh, Sheryl E. Koch, Sankar Natesan, Jack Rubinstein, Anil G. Jegga, Sakthivel Sadayappan
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100075- (2024)
Type 2 diabetes mellitus (T2DM) is a metabolic disease and comorbidity associated with several conditions, including cardiac dysfunction leading to heart failure with preserved ejection fraction (HFpEF), in turn resulting in T2DM-induced cardiomyopat
Externí odkaz:
https://doaj.org/article/dfbdc26c598344ae941d40c3723cf9bd
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract The recombinant monoclonal anti‐cocaine antibody, h2E2, sequesters cocaine in plasma increasing concentrations more than 10‐fold. The increased levels of cocaine in the plasma could have detrimental peripheral effects, particularly on th
Externí odkaz:
https://doaj.org/article/1332bff8bbba4c00b3ce6a61e075e4c3
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280216 (2023)
Short bouts of occlusion of blood flow can induce a preconditioning response that reduces subsequent damage from longer periods of ischemia. It has been shown that ischemic preconditioning (IPC) can be elicited remotely (RIPC) through limitation of b
Externí odkaz:
https://doaj.org/article/0e7056fbb1f8452fab8b74866efedcd8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Congenital heart disease (CHD) is the most common congenital abnormality. A precise etiology for CHD remains elusive, but likely results from interactions between genetic and environmental factors during development, when the heart adapts to
Externí odkaz:
https://doaj.org/article/819d030907234ca493c2f782ec75aee0
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+
Externí odkaz:
https://doaj.org/article/76cf874e081d450089f986e156d86824
Autor:
Taejeong Song, Palanikumar Manoharan, Douglas P. Millay, Sheryl E. Koch, Jack Rubinstein, Judith A. Heiny, Sakthivel Sadayappan
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Background Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not completely understood
Externí odkaz:
https://doaj.org/article/44a1821af2a34b7dbcfd9f06b9b56e03
Autor:
Evan Onusko, Michael R McDermott, Nathan Robbins, Guansheng Liu, Evangelia G Kranias, Jack Rubinstein, Sheryl E Koch
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230386 (2020)
Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This
Externí odkaz:
https://doaj.org/article/594e8b50cc3f4a2cace73ed4c6e98bca
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine tumors (NET). However, patients eventually progress on treatment, highlighting the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aae7793335e011bc4ba3984f311be0
https://doi.org/10.1158/1535-7163.c.6538789
https://doi.org/10.1158/1535-7163.c.6538789
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Table S1. CC-223-treated mice tend to develop less histopathologic lesions of the heart valves than either rapamycin- or placebo-treated mice. Figure S1. MLN0128 inhibited mTOR signaling in human pNET cell lines in a dose-dependent manner. Figure S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90b178ee84c8bf4d1cc19a4cbef7c1
https://doi.org/10.1158/1535-7163.22507783
https://doi.org/10.1158/1535-7163.22507783
Publikováno v:
Pharmacology Research & Perspectives. 11