Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii

Autor: Shervi Lie, Elise Rochet, Erik Segerdell, Yuefang Ma, Liam M. Ashander, Audra M. A. Shadforth, Timothy A. Blenkinsop, Michael Z. Michael, Binoy Appukuttan, Beth Wilmot, Justine R. Smith

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Ocular toxoplasmosis is the commonest clinical manifestation of infection with obligate intracellular parasite, Toxoplasma gondii. Active ocular toxoplasmosis is characterized by replication of T. gondii tachyzoites in the retina, with reactive infla

Externí odkaz: https://doaj.org/article/068ff2293ab44a37a5dda935e061735b

Molecular Basis of The Retinal Pigment Epithelial Changes That Characterize The Ocular Lesion in Toxoplasmosis

Autor: Shervi Lie, Bárbara R. Vieira, Sigrid Arruda, Milena Simões, Liam M. Ashander, João M. Furtado, Justine R. Smith

Publikováno v: Microorganisms, Vol 7, Iss 10, p 405 (2019)

When a person becomes infected with Toxoplasma gondii, ocular toxoplasmosis is the most common clinical presentation. The medical literature describes retinitis with surrounding hyperpigmentation secondary to proliferative changes in the retinal pigm

Externí odkaz: https://doaj.org/article/f31deb587149453dadebce02e5c7f4d0

Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells

Autor: Shervi Lie, Justine R. Smith, Yuefang Ma, Elise Rochet, Liam M. Ashander, João M. Furtado, Binoy Appukuttan, Jennifer M. Washington

Publikováno v: Investigative ophthalmologyvisual science. 60(14)

Purpose Retinal damage in ocular toxoplasmosis reflects Toxoplasma gondii-induced cell lysis and reactive inflammation. Human retinal histopathology demonstrates the presence of neutrophils, but activities of this leukocyte subset are unstudied. We c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bb1292c9f1ea9aa5fdc53dd2de0c00
https://pubmed.ncbi.nlm.nih.gov/31743940

Molecular basis of the retinal pigment epithelial changes that characterize the ocular lesion in toxoplasmosis

Autor: Bárbara Vieira, Justine R. Smith, Sigrid Arruda, Shervi Lie, Milena Simões, João M. Furtado, Liam M. Ashander

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Microorganisms, Vol 7, Iss 10, p 405 (2019)
Microorganisms
Volume 7
Issue 10

When a person becomes infected with Toxoplasma gondii, ocular toxoplasmosis is the most common clinical presentation. The medical literature describes retinitis with surrounding hyperpigmentation secondary to proliferative changes in the retinal pigm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2359c80e4c8276f8b2be799434396e

Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses

Autor: David T. Humphreys, Janna L. Morrison, Shervi Lie, David O. Kleemann, Catherine M. Suter, Susan E. Ozanne, Claire T. Roberts, Song Zhang, I. Caroline McMillen, Simon K. Walker, Severence M. MacLaughlin, Olivia Williams-Wyss

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 310:E148-E159

We have investigated the effects of embryo number and maternal undernutrition imposed either around the time of conception or before implantation on hepatic lipid metabolism in the sheep fetus. We have demonstrated that periconceptional undernutritio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a73a6ebb3203286ba8c6f626a1f7e4
https://doi.org/10.1152/ajpendo.00600.2014