Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Sherven Sharma"'
Autor:
Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1274-1285 (2021)
Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that
Externí odkaz:
https://doaj.org/article/4c750e5c3a054f1086a305ce55890ac8
Autor:
Puja Shahrouki, MD, Jay M. Lee, MD, Jonathan Barclay, MD, Sarah N. Khan, MD, Scott Genshaft, MD, Fereidoun Abtin, MD, Steven M. Dubinett, MD, Aaron Lisberg, MD, Sherven Sharma, PhD, Edward B. Garon, MD, Robert Suh, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 11, Pp 100242- (2021)
Introduction: To assess the technical feasibility and safety of repeated percutaneous computed tomography (CT)–guided transthoracic biopsies and intratumoral injections of gene-modified dendritic cells in metastatic NSCLC. Methods: A total of 15 pa
Externí odkaz:
https://doaj.org/article/cf93339bf11f4025bd759e5634159336
Autor:
Guanyu Wang, Fulu Dong, Zhiyao Xu, Sherven Sharma, Xiaotong Hu, Dafang Chen, Lumin Zhang, Jinping Zhang, Qinghua Dong
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background MicroRNAs (miRNAs) exhibit essential regulatory functions related to cell growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is associated with a wide variety of human diseases. As such miRNA sig
Externí odkaz:
https://doaj.org/article/6b05c956d992426f874407e03b0af358
Autor:
Yi-Hung Carol Tan, Tamara Mirzapoiazova, Brian M. Won, Li Zhu, Minu K. Srivastava, Everett E. Vokes, Aliya N. Husain, Surinder K. Batra, Sherven Sharma, Ravi Salgia
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Casitas B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is important for non-small-cell lung cancer (NSCLC). We investigated if MET is a target of CBL and if enhanced in CBL-altered NSCLC. We s
Externí odkaz:
https://doaj.org/article/16f501031f654eb7b913e9777d40b719
Publikováno v:
Vaccines, Vol 8, Iss 4, p 655 (2020)
Background: Immune checkpoint blockade that downregulates T cell evasion for effective immunity has provided a renewed interest in therapeutic cancer vaccines. Methods: Utilizing murine lung cancer models, we determined: tumor burden, TIL cytolysis,
Externí odkaz:
https://doaj.org/article/a098544747b3433f94138d3b09254118
Autor:
Pournima Kadam, Sherven Sharma
Publikováno v:
Vaccines, Vol 8, Iss 2, p 317 (2020)
(1) Background: Targeting inhibitory immune checkpoint molecules has highlighted the need to find approaches enabling the activation of immune responses against cancer. Therapeutic vaccination, which induces specific immune responses against tumor an
Externí odkaz:
https://doaj.org/article/d762e114d88a4df6b3d4477075ecdc48
Autor:
Matthew Rettig, Kenny Trinidad, G Pezeshkpour, Patrick Frost, Sherven Sharma, Farhad Moatamed, Fuyuhiko Tamanoi, Fariborz Mortazavi
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42012 (2012)
The role of c-Crk (CRK) in promoting metastasis is well described however the role of CRK phosphorylation and the corresponding signaling events are not well explained. We have observed CRK-II serine 41 phosphorylation is inversely correlated with p1
Externí odkaz:
https://doaj.org/article/6f1b6a38d1fe4427a07a9cee0fc73139
Autor:
Minu K. Srivastava, Li Zhu, Marni Harris-White, Upendra K Kar, Min Huang, Ming F. Johnson, Jay M. Lee, David Elashoff, Robert Strieter, Steven Dubinett, Sherven Sharma
Publikováno v:
PLoS ONE, Vol 7, Iss 10 (2012)
Externí odkaz:
https://doaj.org/article/85d53511aadb462f82fe3ab899596bc7
Autor:
Minu K Srivastava, Li Zhu, Marni Harris-White, Upendra K Kar, Min Huang, Ming F Johnson, Jay M Lee, David Elashoff, Robert Strieter, Steven Dubinett, Sherven Sharma
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40677 (2012)
Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models o
Externí odkaz:
https://doaj.org/article/a0ab1d2f0c8840d2b257ab3a69022ed5
Autor:
Upendra K Kar, Janina Jiang, Cheryl I Champion, Sahar Salehi, Minu Srivastava, Sherven Sharma, Shahrooz Rabizadeh, Kayvan Niazi, Valerie Kickhoefer, Leonard H Rome, Kathleen A Kelly
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e38553 (2012)
Modifications of adjuvants that induce cell-mediated over antibody-mediated immunity is desired for development of vaccines. Nanocapsules have been found to be viable adjuvants and are amenable to engineering for desired immune responses. We previous
Externí odkaz:
https://doaj.org/article/94fe509737a34371a9260e88c19bfcb5