Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sherry S.W. Leung"'
Autor:
Tejas Phaterpekar, Jenifer Thewalt, Reza Siavashi, Sherry S.W. Leung, Alicia Alonso, Félix M. Goñi
Publikováno v:
Biophysical Journal. 117:296-306
Sphingolipids constitute a significant fraction of cellular plasma membrane lipid content. Among sphingolipids, ceramide levels are usually very low. However, in some cell processes like apoptosis, cell membrane ceramide levels increase markedly beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c67bd64d41fcca221ea8dbc46d6593
https://doi.org/10.1016/j.bpj.2019.05.027
https://doi.org/10.1016/j.bpj.2019.05.027
Publikováno v:
Langmuir. 34:7561-7574
The hierarchical assembly of lipids, as modulated by composition and environment, plays a significant role in the function of biological membranes and a myriad of diseases. Elevated concentrations of calcium ions and cardiolipin (CL), an anionic tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bfa3e870ba237fef72755589cc8d76
https://doi.org/10.1021/acs.langmuir.8b01359
https://doi.org/10.1021/acs.langmuir.8b01359
Autor:
Mohsen Ramezanpour, Miranda L. Schmidt, Jayesh A. Kulkarni, Iulia Bodnariuc, Pieter R. Cullis, Jenifer Thewalt, Sherry S.W. Leung, D. P. Tieleman
Publikováno v:
Nanoscale. 11(30)
Lipid nanoparticles (LNPs) composed of ionizable cationic lipids are currently the leading systems for siRNA delivery in liver disease, with the major limitation of low siRNA release efficacy into the cytoplasm. Ionizable cationic lipids are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44448d88d37cc7b4877fcf6f168e7e12
https://pubmed.ncbi.nlm.nih.gov/31334542
https://pubmed.ncbi.nlm.nih.gov/31334542
Computational and experimental approaches for investigating nanoparticle-based drug delivery systems
Autor:
Jenifer Thewalt, Sherry S.W. Leung, Mohsen Ramezanpour, D. P. Tieleman, Karelia H. Delgado-Magnero, Bashe Y. M. Bashe
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1688-1709
Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across cell membranes. Drug/gene delivery systems (DDSs) are capable of overcoming some of these bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a32f657fe6657ae244eea64a95048c
https://doi.org/10.1016/j.bbamem.2016.02.028
https://doi.org/10.1016/j.bbamem.2016.02.028
Autor:
Sherry S.W. Leung, Cecilia Leal
Publikováno v:
Soft matter. 15(6)
In this paper we investigate the pseudo-ternary phase diagram of glycerol monooleate (GMO), a cationic lipid (DOTAP – 1,2-dioleoyl-3-trimethylammonium propane), and a “PEGylated” lipid (DOPE-PEG – 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e1c08d6f1507853b8c82a3fa518b26
https://pubmed.ncbi.nlm.nih.gov/30462135
https://pubmed.ncbi.nlm.nih.gov/30462135
Autor:
Jenifer Thewalt, Sherry S.W. Leung
Publikováno v:
The journal of physical chemistry. B. 121(6)
Fluorescence microscopy is an important technique for studying lipid membranes and is increasingly being used for examining liquid ordered-liquid disordered phase coexistence. Liquid–liquid phase coexistence is a phenomenon of biological interest b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f915d809b71865f01327630596112f9c
https://pubmed.ncbi.nlm.nih.gov/28145724
https://pubmed.ncbi.nlm.nih.gov/28145724
Autor:
Mohsen Ramezanpour, Jenifer Thewalt, D. Peter Tieleman, Mohammad Ashtari, Jason Wang, Sherry S.W. Leung, Karelia H. Delgado-Magnero, Bashe Y. M. Bashe, Linda Wang
Publikováno v:
Biophysical Journal. 110(3)
Most promising gene therapy approaches use siRNA. Sophisticated delivery systems are required to protect and deliver siRNA effectively to the target tissues. Lipid nanoparticles (LNPs) containing ionizable amino lipids with pKa of 7 or lower, e.g. DL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4004616e6ed91fcfd62f9fdf1634a392
Publikováno v:
Biophysical Journal. 103(12):2465-2474
Ceramide produced from sphingomyelin in the plasma membrane is purported to affect signaling through changes in the membrane’s physical properties. Thermal behavior of N-palmitoyl sphingomyelin (PSM) and N-palmitoyl ceramide (PCer) mixtures in exce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620667b57c7cf453b33e7dccad73e6bb
Autor:
Jenifer Thewalt, D. Peter Tieleman, Nandhitha Subramanian, Miranda L. Schmidt, Iulia Bodnariuc, Sherry S.W. Leung, Joanne E. Mercer, Yoav Atsmon-Raz, Pieter R. Cullis, Mohsen Ramezanpour, Bashe Y. M. Bashe
Publikováno v:
Biophysical Journal. 114:16a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0788591582267c0226206b6715370a
https://doi.org/10.1016/j.bpj.2017.11.131
https://doi.org/10.1016/j.bpj.2017.11.131
Autor:
Jenifer Thewalt, Sherry S.W. Leung
We illustrate the usefulness of 2H NMR spectroscopy applied to the study of lipid membranes by examining binary and ternary mixtures. Studying pair-wise interactions between lipids is an important first step for understanding more complex interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6905befbdb27618858b10196125a4788
https://doi.org/10.1039/9781782627449-00180
https://doi.org/10.1039/9781782627449-00180
