Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Sherry Niessen"'
Autor:
Xia Ding, Zhou Zhu, John Lapek, Elizabeth A. McMillan, Alexander Zhang, Chi-Yeh Chung, Sara Dubbury, Jennifer Lapira, Sarah Firdaus, Xiaolin Kang, Jingjin Gao, Jon Oyer, John Chionis, Robert A. Rollins, Lianjie Li, Sherry Niessen, Shubha Bagrodia, Lianglin Zhang, Todd VanArsdale
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors
Externí odkaz:
https://doaj.org/article/b28d91d2e3b2470492e4d111d6c1fbcd
Autor:
Patrick J. Metz, Keith A. Ching, Tao Xie, Paulina Delgado Cuenca, Sherry Niessen, John H. Tatlock, Kristen Jensen-Pergakes, Brion W. Murray
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1935-1950.e8 (2020)
Summary: Alternative splicing is well understood to enhance proteome diversity as cells respond to stimuli. However, mechanistic understanding for how the spliceosome processes precursor messenger RNA (mRNA) transcripts to achieve template diversific
Externí odkaz:
https://doaj.org/article/c0c2219a2c9a4202a4e9067663eea1ff
Autor:
Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a
Externí odkaz:
https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as
Externí odkaz:
https://doaj.org/article/4cdd757837e142f3bc96408a4ac0c80a
Autor:
Johana C Misas-Villamil, Izabella Kolodziejek, Emerson Crabill, Farnusch Kaschani, Sherry Niessen, Takayuki Shindo, Markus Kaiser, James R Alfano, Renier A L van der Hoorn
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003281 (2013)
Infection of plants by bacterial leaf pathogens at wound sites is common in nature. Plants defend wound sites to prevent pathogen invasion, but several pathogens can overcome spatial restriction and enter leaf tissues. The molecular mechanisms used b
Externí odkaz:
https://doaj.org/article/17e0158d36c04a6d98f9c38f88400e9d
Autor:
Tangpo Yang, Adolfo Cuesta, Xiaobo Wan, Gregory B. Craven, Brad Hirakawa, Penney Khamphavong, Jeffrey R. May, John C. Kath, John D. Lapek, Sherry Niessen, Alma L. Burlingame, Jordan D. Carelli, Jack Taunton
Publikováno v:
Nature chemical biology, vol 18, iss 9
Nat Chem Biol
Nat Chem Biol
The expansion of the target landscape of covalent inhibitors requires the engagement of nucleophiles beyond cysteine. Although the conserved catalytic lysine in protein kinases is an attractive candidate for a covalent approach, selectivity remains a
Autor:
Mansi Arora, Justin Moser, Timothy E. Hoffman, Lotte P. Watts, Mingwei Min, Monica Musteanu, Yao Rong, Jordan Schneider, C Ryland Ill, Varuna Nangia, Manuel Sanclemente, John Lapek, Lisa Nguyen, Sherry Niessen, Stephen Dann, Todd van Arsdale, Mariano Barbacid, Nichol Miller, Sabrina L. Spencer
Publikováno v:
Cancer Research. 83:5992-5992
CDK2 is a core cell-cycle enzyme that phosphorylates a variety of substrates to drive progression through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target. Here, application of a novel small
Autor:
Adam C. Swensen, Dušan Veličković, Sarah M. Williams, Ronald J. Moore, Le Z. Day, Sherry Niessen, Sarah Hennessy, Camilo Posso, Mara Monetti, Wei-Jun Qian, Jon Jacobs, Laurence Whiteley, Ying Zhu, Paul D. Piehowski
Publikováno v:
Molecularcellular proteomics : MCP. 21(12)
Despite their diminutive size, islets of Langerhans play a large role in maintaining systemic energy balance in the body. New technologies have enabled us to go from studying the whole pancreas to isolated whole islets, to partial islet sections, and
Autor:
Kephart Susan Elizabeth, Tran Khanh Tuan, Kevin Daniel Freeman-Cook, Sherry Niessen, James Solowiej, Buwen Huang, Qin Zhang, Douglas Carl Behenna, Inish O'Doherty, Sacha Ninkovic, Rose Ann Ferre, Andrea Hui, Nichol Miller, Jordan Carelli, Lisa Nguyen, Brion W. Murray, Robert Louis Hoffman, John Lapek, Rhys M. Jones, Meirong Xu, Stephen Dann, Sutton Scott Channing, Asako Nagata, Nanni Huser, Ravi Visswanathan, Zehnder Luke Raymond, Elaine E. Tseng, Britton Boras, You-Ai He, Michele McTigue, Wade Diehl, Cathy Zhang, Martha A. Ornelas
Publikováno v:
Journal of medicinal chemistry. 64(13)
Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level of control to additional cell cycle CDK isoforms represents an opportunity to expand to add
Autor:
Ben Bolaňos, Sherry Niessen, Martha A. Ornelas, Paulina Delgado Cuenca, Douglas Carl Behenna, Lawrence G. Lum, Prakash B. Palde, Tran Khanh Tuan, Kevin Ryan, Stephen Kaiser, Marissa Smith, Lianglin Zhang, Todd VanArsdale, Al Stewart, Ketan S. Gajiwala
Publikováno v:
The Journal of Biological Chemistry
Poly-ADP-ribosyltransferases play a critical role in DNA repair and cell death, and poly(ADP-ribosyl) polymerase 1 (PARP1) is a particularly important therapeutic target for the treatment of breast cancer because of its synthetic lethal relationship