Výsledky vyhledávání - "Sherry M. Haynes"

Liposomal delivery of doxorubicin to hepatocytes in vivo by targeting heparan sulfate

Autor: Kenneth J. Longmuir, Sherry M. Haynes, Richard T. Robertson, Natasha Kasabwalla, Janie Baratta

Publikováno v: International Journal of Pharmaceutics. 382:222-233

Previous work demonstrated that liposomes, containing an amino acid sequence that binds to hepatic heparan sulfate glycosaminoglycan, show effective targeting to liver hepatocytes. These liposomes were tested to determine whether they can deliver dox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e360f535800b1de4e075f2d4b65af3
https://doi.org/10.1016/j.ijpharm.2009.07.030

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Liposomal Polyethyleneglycol and Polyethyleneglycol-Peptide Combinations for Active Targeting to LiverIn Vivo

Autor: Kenneth J. Longmuir, Sherry M. Haynes, Richard T. Robertson, Alan J. Waring, Janie Baratta

Publikováno v: Drug Delivery. 15:207-217

This report describes the development and evaluation of a range of polyethyleneglycol and polyethyleneglycol-peptide liposome formulations that effectively target liver in vivo. A 19-amino-acid sequence from the N-terminal region of the circumsporozo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b9d49c2496b3611a7e7475369babf4
https://doi.org/10.1080/10717540802006211

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Development, differentiation, and vascular components of subcutaneous and intrahepatic Hepa129 tumors in a mouse model of hepatocellular carcinoma

Autor: Richard T, Robertson, Paula M, Gutierrez, Janie L, Baratta, Kristoffer, Thordarson, Joshua, Braslow, Sherry M, Haynes, Kenneth J, Longmuir

Publikováno v: Histology and histopathology. 31(4)

Tumor models in mice offer opportunities for understanding tumor formation and development of therapeutic treatments for hepatocellular carcinoma. In this study, subcutaneous or intra-hepatic Hepa129 tumors were established in C3H mice. Tumor growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d9ce91cb535d4a3522db0ce258fe1e2
https://pubmed.ncbi.nlm.nih.gov/26549274

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Use of labeled tomato lectin for imaging vasculature structures

Autor: Samantha T. Levine, Janie Baratta, Paula Gutierrez, Kenneth J. Longmuir, Zhiqun Tan, Sherry M. Haynes, Richard T. Robertson

Publikováno v: Histochemistry and Cell Biology, vol 143, iss 2
Histochemistry and cell biology, vol 143, iss 2
Robertson, RT; Levine, ST; Haynes, SM; Gutierrez, P; Baratta, JL; Tan, Z; et al.(2014). Use of labeled tomato lectin for imaging vasculature structures. Histochemistry and Cell Biology. doi: 10.1007/s00418-014-1301-3. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9dd978mn
Robertson, RT; Levine, ST; Haynes, SM; Gutierrez, P; Baratta, JL; Tan, Z; et al.(2014). Use of labeled tomato lectin for imaging vasculature structures. Histochemistry and Cell Biology, 143(2), 225-234. doi: 10.1007/s00418-014-1301-3. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0kr3m8pn

© 2014, Springer-Verlag Berlin Heidelberg. Intravascular injections of fluorescent or biotinylated tomato lectin were tested to study labeling of vascular elements in laboratory mice. Injections of Lycopersicon esculentum agglutinin (tomato lectin)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a62ea140a1c3c59ff8895b98b10deb2
https://escholarship.org/uc/item/0kr3m8pn

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Using electroporation and lipid-mediated transfection of GFP-expressing plasmids to label embryonic avian cells for vital confocal and two-photon microscopy

Autor: Sherry M. Haynes, Ben A. Murray, Kenneth J. Longmuir, Christopher Waters, Mary E. Dickinson

Publikováno v: Differentiation. 70:172-180

Fluorescent proteins have emerged as an ideal fluorescent marker for studying cell morphologies in vital systems. These proteins were first applied in whole organisms with established germ-line transformation protocols, but now it is possible to labe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ae80791d67dc14b79ed27836347ed
https://doi.org/10.1046/j.1432-0436.2002.700407.x

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Optimization of a Peptide/Non-cationic Lipid Gene Delivery System for Effective Microinjection into Chicken Embryo in Vivo

Autor: Mary E. Dickinson, Sherry M. Haynes, Richard C. Willson, Jason C. Murphy, Kenneth J. Longmuir, Alan J. Waring

Publikováno v: Molecular Therapy. 4(1):66-74

Here we report the characterization and optimization of a peptide/non-cationic lipid gene delivery system that successfully produces high levels of gene expression when delivered by microinjection into chicken embryos in vivo. In addition to plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a459e0363f00eaccdd9a42a26d19b102

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Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate binding sites in liver

Autor: Kenneth J. Longmuir, Sherry M. Haynes, Janie Baratta, Richard T. Robertson

Publikováno v: Journal of pharmaceutical sciences. 97(8)

Previous studies demonstrated that intravenously administered liposomes, incorporating a peptide from the Plasmodium circumsporozoite protein, accumulate rapidly and selectively in mouse liver. The present investigation was designed to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673754a71d1ed070cc6129b9abe1e554
https://pubmed.ncbi.nlm.nih.gov/17932963

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Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence

Autor: Janie Baratta, Alan J. Waring, Sherry M. Haynes, Richard T. Robertson, Kenneth J. Longmuir

Publikováno v: Pharmaceutical research. 23(4)

Several species of the protozoan Plasmodium effectively target mammalian liver during the initial phase of host invasion. The purpose of this study was to demonstrate that a Plasmodium targeting amino acid sequence can be engineered into therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09110f5d4f02e15d1579f1dda3197e0a
https://pubmed.ncbi.nlm.nih.gov/16550476

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Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes

Autor: Alan J. Waring, Kenneth J. Longmuir, Eric A. Murphy, Sherry M. Haynes

Publikováno v: Murphy, Eric A.; Waring, Alan J.; Haynes, Sherry M.; & Longmuir, Kenneth J.(2000). Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes. Nucleic Acids Research, 28(15), 2986-2992. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/13372925

A difficult problem concerning the interaction of DNA with amphiphiles of opposite charge above their critical micelle concentration is the propensity for aggregation of the condensed DNA complexes. In this study, this problem was addressed by attenu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca94cbc553547a69ba0456f7a7252cf5
https://europepmc.org/articles/PMC102676/

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Purification of long-chain, saturated, free fatty acids

Autor: Sherry M. Haynes, Kenneth J. Longmuir

Publikováno v: Journal of chromatography. 454

Les acides gras libres insatures sont separes des acides gras satures par un traitement au tetroxyde d'osmium suivi par une chromatographie sur colonne de gel de silice. Les acides gras satures sont ensuite purifies sur une chromatographie couche min

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72d46156d00730213adca64160abc52
https://pubmed.ncbi.nlm.nih.gov/3235606

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