SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal GutSummary

Autor: Wei Yu, Inamul Haque, Aparna Venkatraman, Heather L. Menden, Sherry M. Mabry, Badal C. Roy, Sheng Xia, Jeremy W. Prokop, Shahid Umar, Aron M. Geurts, Venkatesh Sampath

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 425-440 (2022)

Background & Aims: Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing ente

Externí odkaz: https://doaj.org/article/3e60b8ebab2c43c9848fc4805b58f9b2

Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung

Autor: Sheng Xia, Heather L. Menden, Nick Townley, Sherry M. Mabry, Jeffrey Johnston, Michael F. Nyp, Daniel P. Heruth, Thomas Korfhagen, Venkatesh Sampath

Publikováno v: JCI Insight, Vol 6, Iss 7 (2021)

The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown. We tested the hypothesis that delta-like 4 (DLL4), an EC Not

Externí odkaz: https://doaj.org/article/292632c88b714b2699d06c19d3ef7a0c

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasia

Autor: Sheng Xia, Lisandra Vila Ellis, Konner Winkley, Heather Menden, Sherry M. Mabry, Daniel Louiselle, Margaret Gibson, Elin Grundberg, Jichao Chen, Venkatesh Sampath

Hyperoxia (HOX) disrupts lung development in mice and causes bronchopulmonary dysplasia (BPD) in neonates. To investigate sex-dependent molecular and cellular programming involved in HOX, we surveyed the mouse lung using single cell RNA sequencing (s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc48a285f238f05b55cb30a6416adac
https://doi.org/10.1101/2022.07.12.499826

SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut

Autor: Jeremy W. Prokop, Heather Menden, Sherry M Mabry, Inamul Haque, Badal C. Roy, Aparna Venkatraman, Venkatesh Sampath, Wei Yu, Sheng Xia, Aron M. Geurts, Shahid Umar

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 425-440 (2022)

Background & Aims Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing enter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d15e4d9b9349e09ce86d1c7a3d4b2a
https://pubmed.ncbi.nlm.nih.gov/34740617

Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung

Autor: Sherry M Mabry, Heather Menden, Michael F. Nyp, Sheng Xia, Angels Navarro, Venkatesh Sampath

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 55:767-778

In premature infants, sepsis is associated with alveolar simplification manifesting as bronchopulmonary dysplasia. The redox-dependent mechanisms underlying sepsis-induced inflammation and alveolar remodeling in the immature lung remain unclear. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f93ca8984064b730aa2d837f4db05
https://doi.org/10.1165/rcmb.2016-0006oc