Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Sherry L, Mowbray"'
Autor:
Lu Lu, Linda Åkerbladh, Shabbir Ahmad, Vivek Konda, Sha Cao, Anthony Vocat, Louis Maes, Stewart T. Cole, Diarmaid Hughes, Mats Larhed, Peter Brandt, Anders Karlén, Sherry L. Mowbray
Publikováno v:
ACS Infectious Diseases
Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a39718c8f3bfe61b328322f78be178
https://doi.org/10.1021/acsinfecdis.1c00413
https://doi.org/10.1021/acsinfecdis.1c00413
Publikováno v:
Molecules, Vol 19, Iss 9, Pp 13161-13176 (2014)
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (g
Externí odkaz:
https://doaj.org/article/34507a3ea9db4c68baafa77ce136dbd1
Autor:
Lu, Lu, Linda, Åkerbladh, Shabbir, Ahmad, Vivek, Konda, Sha, Cao, Anthony, Vocat, Louis, Maes, Stewart T, Cole, Diarmaid, Hughes, Mats, Larhed, Peter, Brandt, Anders, Karlén, Sherry L, Mowbray
Publikováno v:
ACS infectious diseases. 8(3)
Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9651377aab8d986bbc3221d81d706a3a
https://pubmed.ncbi.nlm.nih.gov/35184552
https://pubmed.ncbi.nlm.nih.gov/35184552
Autor:
Natalia Szałaj, Andrea Benediktsdottir, Dominika Rusin, Anders Karlén, Sherry L. Mowbray, Anna Więckowska
The ever-increasing number of bacteria resistant to the currently available antibacterial agents is a great medical problem today, and new antibiotics with novel mechanisms of action are urgently needed. Among the validated antibacterial drug targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce85782c3d59e4bbb184325456d7b9b
https://ruj.uj.edu.pl/xmlui/handle/item/297175
https://ruj.uj.edu.pl/xmlui/handle/item/297175
Autor:
Sha Cao, Diarmaid Hughes, Andrea Benediktsdottir, Anders Karlén, Sherry L. Mowbray, Anja Sandström, Lu Lu, Edouard Zamaratski
Oligopeptide boronates with a lipophilic tail are known to inhibit the type I signal peptidase in E. coli, which is a promising drug target for developing novel antibiotics. Antibacterial activity depends on these oligopeptides having a cationic modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81bc1a93d6f4063bfe71b7fc5ad074d
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450022
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450022
Autor:
Anders Karlén, Máté Erdélyi, Charles Hedgecock, Andrea Benediktsdottir, Gustav Olanders, Peter Brandt, Edouard Zamaratski, Sherry L. Mowbray, Lu Lu, Sha Cao, Diarmaid Hughes, Natalia Szałaj
Publikováno v:
European Journal of Medicinal Chemistry. 157:1346-1360
Type I signal peptidase, with its vital role in bacterial viability, is a promising but underexploited antibacterial drug target. In the light of steadily increasing rates of antimicrobial resistance, we have developed novel macrocyclic lipopeptides,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1842e832737a92e7de3e08d2315ca3
https://doi.org/10.1016/j.ejmech.2018.08.086
https://doi.org/10.1016/j.ejmech.2018.08.086
Autor:
János Pató, Jan Rybniker, Gaëlle S. Kolly, Rita Székely, Neeraj Dhar, Zuzana Palčeková, Anthony Vocat, Digby F. Warner, Júlia Zemanová, Monica G Rengifo, Priscille Brodin, John D. McKinney, Adrian Suarez Covarrubias, Vinayak Singh, François Signorino-Gelo, Joseph Buechler, Sherry L. Mowbray, Ruben C. Hartkoorn, José A. Aínsa, Stewart T. Cole, Vincent Delorme, Martin Forbak, Isabella Santi, Joanna C. Evans, Liliana Rodrigues, György Kéri, Katarína Mikušová, Kai Johnsson, Jana Korduláková, Graham Knott, Valerie Mizrahi
Publikováno v:
Molecular Microbiology. 103:13-25
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c108991780420cb8426b100589be6471
https://doi.org/10.1111/mmi.13535
https://doi.org/10.1111/mmi.13535
Autor:
Paul Bauer, Mikael Widersten, Agata Naworyta, Åsa Janfalk Carlsson, Sherry L. Mowbray, Fernanda Duarte, Shina Caroline Lynn Kamerlin, Beat Anton Amrein
Publikováno v:
ACS Catalysis
Potato epoxide hydrolase 1 exhibits rich enantio- and regioselectivity in the hydrolysis of a broad range of substrates. The enzyme can be engineered to increase the yield of optically pure products as a result of changes in both enantio- and regiose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9d4237b8b67195e335e42ca5caa040
https://doi.org/10.1021/acscatal.5b01639
https://doi.org/10.1021/acscatal.5b01639
Autor:
Jenny Pouyez, René Chofor, Sherry L. Mowbray, Chinchu Johny, Cynthia S. Dowd, Sanjeewani Sooriyaarachchi, Louis Maes, Alexander Alex, Amanda Haymond, Tom Coenye, T. Alwyn Jones, Robin D. Couch, Annelien Everaert, Johan Wouters, Serge Van Calenbergh, Terese Bergfors, Martijn D. P. Risseeuw
Publikováno v:
Journal of medicinal chemistry
Blocking the 2-C-methyl-D-erythrithol-4-phosphate (MEP) pathway for isoprenoid biosynthesis offers interesting prospects for inhibiting Plasmodium or Mycobacterium spp. growth. Fosmidomycin (1) and its homologue FR900098 (2) potently inhibit 1-deoxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e393587173a9e692a9502be0a92f13
https://doi.org/10.1021/jm5014264
https://doi.org/10.1021/jm5014264
Autor:
Per E. Andrén, Douglas L. Huseby, Lu Lu, Diarmaid Hughes, Natalia Szałaj, Sha Cao, Anders Karlén, Sherry L. Mowbray, Annette K. Roos, Maria Cristina De Rosa, Edouard Zamaratski, Johan Gising, Peter Brandt, Henrik Wadensten, Lena Lenhammar, Rolf Larsson
Publikováno v:
Bioorganic & Medicinal Chemistry.
Type I signal peptidases are potential targets for the development of new antibacterial agents. Here we report finding potent inhibitors of E. coli type I signal peptidase (LepB), by optimizing a previously reported hit compound, decanoyl-PTANA-CHO,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4ee0934c8337bec0e9ec618dd9920c