Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sherry Koontz"'
Autor:
Randall K. Merling, Douglas B. Kuhns, Colin L. Sweeney, Xiaolin Wu, Sandra Burkett, Jessica Chu, Janet Lee, Sherry Koontz, Giovanni Di Pasquale, Sandra A. Afione, John A. Chiorini, Elizabeth M. Kang, Uimook Choi, Suk See De Ravin, Harry L. Malech
Publikováno v:
Blood Advances, Vol 1, Iss 4, Pp 270-278 (2017)
Abstract: Pseudogenes are duplicated genes with mutations rendering them nonfunctional. For single-gene disorders with homologous pseudogenes, the pseudogene might be a target for genetic correction. Autosomal-recessive p47phox-deficient chronic gran
Externí odkaz:
https://doaj.org/article/06a4f199c3f9475d92887d59145ca405
Autor:
Matthew H. Porteus, Shengdar Q. Tsai, Siyuan Liu, Cicera R. Lazzarotto, Suk See De Ravin, Colin L. Sweeney, Sherry Koontz, Ronald J. Meis, Uimook Choi, GaHyun Lee, Sandra Burkett, Douglas B. Kuhns, Narda Theobald, Harry L. Malech, Xiaolin Wu, Taylor Liu, Benjamin P. Kleinstiver, Gary A. Dahl, Aaron B. Clark, Linhong Li, Stephen Headey, Mara Pavel-Dinu, Julie Brault
Publikováno v:
Blood
Lentivector gene therapy for X-linked chronic granulomatous disease (X-CGD) has proven to be a viable approach, but random vector integration and subnormal protein production from exogenous promoters in transduced cells remain concerning for long-ter
Autor:
Linhong Li, Harry L. Malech, Kennichi C. Dowdell, Julie Brault, Ezekiel Bello, Sherry Koontz, Aaron B. Clark, Ronald J. Meis, Michael J. Lenardo, Colin L. Sweeney, Narda Theobald, Juan C. Ravell, Janet Lee, Gary A. Dahl, Taylor Liu, Suk See De Ravin, Cornell Allen
Publikováno v:
Cytotherapy. 23:203-210
Background aim X-linked MAGT1 deficiency with increased susceptibility to EBV-infection and N-linked glycosylation defect' (XMEN) disease is caused by mutations in the magnesium transporter 1 (MAGT1) gene. Loss of MAGT1 function results in a glycosyl
Autor:
Naritaka Tamaoki, Stefan Siebert, Takuya Maeda, Ngoc-Han Ha, Meghan L. Good, Yin Huang, Suman K. Vodnala, Juan J. Haro-Mora, Naoya Uchida, John F. Tisdale, Colin L. Sweeney, Uimook Choi, Julie Brault, Sherry Koontz, Harry L. Malech, Yasuhiro Yamazaki, Risa Isonaka, David S. Goldstein, Masaki Kimura, Takanori Takebe, Jizhong Zou, David F. Stroncek, Pamela G. Robey, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo
Publikováno v:
Cell Reports Methods. 3:100460
Autor:
Ezekiel Bello, Marita Bosticardo, Ronald J. Meis, Sherry Koontz, Shengdar Q. Tsai, Juan C Ravell, Michael J. Lenardo, Luigi D. Notarangelo, Benjamin P. Kleinstiver, Xiaolin Wu, Cicera R. Lazzarotto, Harry L. Malech, Guillaume Vayssière, Kennichi C. Dowdell, Colin L. Sweeney, Gary A. Dahl, Taylor Q. Liu, Aaron B. Clark, Uimook Choi, Cristina Corsino, Suk See De Ravin, Siyuan Liu, Julie Brault
Publikováno v:
Blood
XMEN disease, defined as “X-linked MAGT1 deficiency with increased susceptibility to Epstein-Barr virus infection and N-linked glycosylation defect,” is a recently described primary immunodeficiency marked by defective T cells and natural killer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4b75a7fdafd4fa4d8bff8e2be88729
https://europepmc.org/articles/PMC8718624/
https://europepmc.org/articles/PMC8718624/
Autor:
Elizabeth M. Kang, Patricia Kiesler, Jian Luo, Sarah Bryant, James Warren, Harry L. Malech, Gabriela S. Dveksler, Sherry Koontz, Karlie Jones
Publikováno v:
Biol Blood Marrow Transplant
Acute graft-versus-host disease (aGVHD) is an immune-mediated reaction that can occur after hematopoietic stem cell transplantation in which donor T cells recognize the host antigens as foreign, destroying host tissues. Establishment of a tolerogenic
Autor:
Linhong Li, Ezekiel Bello, Harry L. Malech, Xiaolin Wu, Narda Theobald, Taylor Liu, Ronald J. Meis, Matthew H. Porteus, Suk See De Ravin, Gary A. Dahl, Julie Brault, Sherry Koontz, Janet Lee, Colin L. Sweeney, Uimook Choi, Mara Pavel-Dinu
Publikováno v:
Gene therapy
X-linked chronic granulomatous disease is an immunodeficiency characterized by defective production of microbicidal reactive oxygen species (ROS) by phagocytes. Causative mutations occur throughout the 13 exons and splice sites of the CYBB gene, resu
Autor:
Taylor Q. Liu, David F. Stroncek, Narda Theobald, Sherry Koontz, Elizabeth M. Kang, Steven L. Highfill, Michail S. Lionakis, Julie Brault, Mark E. Metzger, Robert E. Donahue, John F. Tisdale, Hong Lei, Aaron B. Clark, Suk See De Ravin, Harry L. Malech, Linhong Li, Kamille A. West, Aylin C. Bonifacino, Gary A. Dahl, Ronald J. Meis, Cynthia E. Dunbar, Jigar V. Desai, Marissa A. Zarakas, Douglas B. Kuhns, Uimook Choi, Cristina Corsino
Publikováno v:
Blood Adv
Granulocytes from patients with chronic granulomatous disease (CGD) have dysfunctional phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase that fails to generate sufficient antimicrobial reactive oxidative species. CGD patie
Autor:
Yasuyuki Arai, Colin L. Sweeney, Uimook Choi, Harry L. Malech, Steven A. Feldman, Masaki Tajima, Mary A. Black, Cristina Corsino, Mary C. Dinauer, Sherry Koontz
Publikováno v:
Molecular Therapy. 26:1181-1197
We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. W
Autor:
Jessica Chu, Sandra Burkett, Elizabeth M. Kang, Sherry Koontz, John A. Chiorini, Harry L. Malech, Randall K. Merling, Douglas B. Kuhns, Suk See De Ravin, Uimook Choi, Colin L. Sweeney, Janet Lee, Xiaolin Wu, Sandra Afione, Giovanni Di Pasquale
Publikováno v:
Blood Advances. 1:270-278
Pseudogenes are duplicated genes with mutations rendering them nonfunctional. For single-gene disorders with homologous pseudogenes, the pseudogene might be a target for genetic correction. Autosomal-recessive p47phox-deficient chronic granulomatous