Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sherry Heldens"'
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07be02e8e9258d59fd0d5344faa763ab
https://doi.org/10.1158/1535-7163.c.6535320.v1
https://doi.org/10.1158/1535-7163.c.6535320.v1
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
PDF file - 451K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923262ef522e46408ad2b4fe9b478f6
https://doi.org/10.1158/1535-7163.22496553
https://doi.org/10.1158/1535-7163.22496553
Autor:
Kyung Song, Lukas C. Amler, Bonnie Liu, Wei Zhou, Connie Ha, Mark R. Lackner, Sherry Heldens, Karen Toy, Huifen Chen, John Moffat, Klaus P. Hoeflich, William F. Forrest, Peter M. Haverty, Marcia Belvin, Garret M. Hampton, Lori Friedman, Robert Soriano, Carol O'Brien, Jill M. Spoerke, Georgia Hatzivassiliou
Publikováno v:
Molecular Cancer Therapeutics. 11:1143-1154
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac630f26a405376704bb3b851d8e608
https://doi.org/10.1158/1535-7163.mct-11-1010
https://doi.org/10.1158/1535-7163.mct-11-1010
Autor:
Grazyna Fedorowicz, Celina Sanchez Rivers, Robert Soriano, Somasekar Seshagiri, Zora Modrusan, Leisa Johnson, Zemin Zhang, Steffen Durinck, Merone Roose-Girma, Vasantharajan Janakiraman, Mark Merchant, Florian Gnad, Pete Haverty, Howard M. Stern, Sherry Heldens, Wenlin Yuan, Eric Stawiski, Kyle A. Edgar, Emily Chan, Jeffrey Wallin, Noelyn M. Kljavin
Publikováno v:
Oncogene
Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K) catalytic subunit p110α, occur in ∼25% of human breast cancers. In this study, we report the development of a knock-in mouse model for breast cancer where the endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fec7759f797ae29ef9e34aea0a4667e
https://doi.org/10.1038/onc.2012.53
https://doi.org/10.1038/onc.2012.53
Autor:
Juan Zhang, Wyne P. Lee, Vishva M. Dixit, Kate Senger, Allen Nguyen, Donghong Yan, Maria N. Lorenzo, Yonglian Sun, Shahram Misaghi, Sherry Heldens, Ali A. Zarrin, Tao Sai, Christopher Garris, Jiansheng Wu, Laura DeForge, Andrew Sebrell, Min Xu
Publikováno v:
The Journal of Immunology. 185:166-173
Ab class switch recombination involves a recombination between two repetitive DNA sequences known as switch (S) regions that vary in length, content, and density of the repeats. Abs expressed by B cells are diversified by somatic hypermutation and cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788509bc98407279ad87b0a2df615a66
https://doi.org/10.4049/jimmunol.1000515
https://doi.org/10.4049/jimmunol.1000515
Autor:
Eric Stawiski, Yi Cao, Melanie A. Huntley, Somasekar Seshagiri, Joseph Guillory, Art B. Owen, Young J, Degenhardt J, Michael S. Lawrence, Gentleman R, Marlena Jackson, Leonard D. Goldstein, Thomas D. Wu, Sherry Heldens
The accurate identification of low-frequency variants in tumors remains an unsolved problem. To support characterization of the issues in a realistic setting, we have developed software tools and a reference dataset for diagnosing variant calling pip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eae1998a3dd679db15319b0cb9778cb
https://doi.org/10.1101/027227
https://doi.org/10.1101/027227
Autor:
Julian S. Gehring, Vitaly Margulis, Connie Ha, Vanina Toffessi-Tcheuyap, Na Zhang, Ivan Pedrosa, Bernard Chow, Vasantharajan Janakiraman, Payal Kapur, Yair Lotan, Arthur I. Sagalowsky, Bijay S. Jaiswal, Steffen Durinck, Zora Modrusan, Jeremy Stinson, Subhra Chaudhuri, Celina Sanchez Rivers, Weiru Wang, Sadia Saleem, Sherry Heldens, Gregoire Pau, Marlena Jackson, Samuel Peña-Llopis, Lisa N. Kinch, Andrea Pavia-Jimenez, Peter M. Haverty, Thomas D. Wu, Joseph Guillory, Haley Hill, Eboni Holloman, Ying Jiun Chen, Corissa J. Harris, Somasekar Seshagiri, Thong T. Nguyen, Nick V. Grishin, Eric Stawiski, Jens Reeder, Frederic J. de Sauvage, Karen Toy, Kanika Bajaj Pahuja, James Brugarolas
Publikováno v:
Nature genetics. 47(1)
To further understand the molecular distinctions between kidney cancer subtypes, we analyzed exome, transcriptome and copy number alteration data from 167 primary human tumors that included renal oncocytomas and non-clear cell renal cell carcinomas (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6bf9e75bd01e5209d0cd470d0e1898
https://pubmed.ncbi.nlm.nih.gov/25447836
https://pubmed.ncbi.nlm.nih.gov/25447836
Autor:
Jian Chen, Sherry Heldens, Arthur J Huang, Austin L. Gurney, Jessica Foster, Patrick Dowd, Jeremy Stinson, Hanzhong Li, William I. Wood
Publikováno v:
Proceedings of the National Academy of Sciences. 97:773-778
IL-17 is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Whereas expression of IL-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499fe7cf1b7433616fe433d067ad14f2
https://doi.org/10.1073/pnas.97.2.773
https://doi.org/10.1073/pnas.97.2.773
Autor:
A. Gurney, R.M. Pitti, Melanie R. Mark, Arthur J Huang, Alane M. Gray, Patrick Dowd, Paulj. Godowski, S. Marsters, K.P. Baker, Daryl T. Baldwin, A.D. Goddard, Jennifer Brush, Peter Schow, Sherry Heldens, Avi Ashkenazi, William I. Wood
Publikováno v:
Current Biology. 9(4):215-218
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede6ca32bb3b9e48519eca6a4ecd5f31
Autor:
Wyne P. Lee, Vishva M. Dixit, Yan Qu, Lieselotte Vande Walle, Mohamed Lamkanfi, Søren Warming, Merone Roose-Girma, Jennifer Dong, Jinfeng Liu, Juan Zhang, Nobuhiko Kayagaki, Kim Newton, Salina Louie, Sherry Heldens
Publikováno v:
Nature. 479(7371)
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is believed to be essential for production of the pro-inflammatory cytokines interleuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8777ef959fc9242896519ffcc865227b
https://pubmed.ncbi.nlm.nih.gov/22116083
https://pubmed.ncbi.nlm.nih.gov/22116083