Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Sherry F Queener"'
Autor:
Ernest J Mui, Guy A Schiehser, Wilbur K Milhous, Honghue Hsu, Craig W Roberts, Michael Kirisits, Stephen Muench, David Rice, J P Dubey, Joseph W Fowble, Pradipsinh K Rathod, Sherry F Queener, Susan R Liu, David P Jacobus, Rima McLeod
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e190 (2008)
Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity reactions. The dihydrotriazine JPC-2067-B (4, 6-diamino-1,
Externí odkaz:
https://doaj.org/article/bc04f46a41f04f7ab9bcc0e6aba37d5f
Publikováno v:
Bioorg Med Chem Lett
Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (pj) can lead to serious health consequences in patients with an immunocompromised system. Trimethoprim (TMP), used as first-line therapy in combination with sulfamethoxazole, is a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e744915d2e688f2fdb992d6c0080432d
https://doi.org/10.1016/j.bmcl.2019.06.004
https://doi.org/10.1016/j.bmcl.2019.06.004
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2640-2650
To combine the potency of trimetrexate (TMQ) or piritrexim (PTX) with the species selectivity of trimethoprim (TMP), target based design was carried out with the X-ray crystal structure of human dihydrofolate reductase (hDHFR) and the homology model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088269170c1eeb27b9ebef9d199b0298
https://doi.org/10.1016/j.bmc.2018.04.032
https://doi.org/10.1016/j.bmc.2018.04.032
Autor:
Nilesh Zaware, Karen S. Anderson, Ravi Kumar Vyas Devambatla, Aleem Gangjee, Hitesh Sharma, Sherry F. Queener, Jie Yang
Publikováno v:
ACS Medicinal Chemistry Letters. 4:1148-1151
Infection by the parasite Toxoplasma gondii (tg) can lead to toxoplasmosis in immunocompromised patients such as organ transplant, cancer, and HIV/AIDS patients. The bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) enzyme is crucia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c73ff931c2a554334979496f104cf90
https://doi.org/10.1021/ml400208v
https://doi.org/10.1021/ml400208v
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:2669-2677
A major concern of immunocompromised patients, in particular those with AIDS, is susceptibility to infection caused by opportunistic pathogens such as Pneumocystis jirovecii , which is a leading cause of pneumonia in immunocompromised patients. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed13ad82c657357fa6d5562b6d5c769
https://doi.org/10.1128/aac.00172-13
https://doi.org/10.1128/aac.00172-13
Autor:
Roy L. Kisliuk, Ojas A. Namjoshi, Aleem Gangjee, Sherry F. Queener, Vivian Cody, Sudhir Raghavan
Publikováno v:
Journal of Medicinal Chemistry. 56:4422-4441
Opportunistic infections caused by Pneumocystis jirovecii (P. jirovecii, pj), Toxoplasma gondii (T. gondii, tg), and Mycobacterium avium (M. avium, ma) are the principal causes of morbidity and mortality in patients with acquired immunodeficiency syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db7104f0b32c78d5bdb277870290858
https://doi.org/10.1021/jm400086g
https://doi.org/10.1021/jm400086g
Publikováno v:
Journal of Structural Biology. 176:52-59
In order to produce a more potent replacement for trimethoprim (TMP) used as a therapy for Pneumocystis pneumonia and targets dihydrofolate reductase from Pneumocystis jirovecii (pjDHFR), it is necessary to understand the determinants of potency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fd253b1772af038bb770108e0d8078
https://doi.org/10.1016/j.jsb.2011.06.001
https://doi.org/10.1016/j.jsb.2011.06.001
Publikováno v:
Proceedings of the National Academy of Sciences. 107:17200-17205
While seeking a new host cell, obligate intracellular parasites, such as the protozoan Toxoplasma gondii , must be able to endure the stress of an extracellular environment. The mechanisms Toxoplasma use to remain viable while deprived of a host cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d44b35e9422d39ff58b6a26c1e9865
https://doi.org/10.1073/pnas.1007610107
https://doi.org/10.1073/pnas.1007610107
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3187-3197
The present work deals with design, synthesis and biological evaluation of novel, diverse compounds as potential inhibitors of dihydrofolate reductase (DHFR) from opportunistic microorganisms; Pneumocystis carinii (pc), Toxoplasma gondii (tg) and Myc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3237d4e1944d6f9b19f1dabe0e4a4c
https://doi.org/10.1016/j.bmc.2010.03.031
https://doi.org/10.1016/j.bmc.2010.03.031
Autor:
David S. Wilkes, Hal E. Broxmeyer, Simon J. Rhodes, Ann Roman, Janice S. Blum, Michael Sturek, Sherry F. Queener, Gina Sanchez Gibau, Randy R. Brutkiewicz, Julie Foertsch
Publikováno v:
Journal of Women and Minorities in Science and Engineering. 16:215-235
For over three decades, the scientific community has expressed concern over the paucity of African American, Latino and Native American researchers in the biomedical training pipeline. Concern has been expressed regarding what is forecasted as a shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bc2903b63a98b3c542da91447d479e
https://doi.org/10.1615/jwomenminorscieneng.v16.i3.20
https://doi.org/10.1615/jwomenminorscieneng.v16.i3.20