Human Mendelian pain disorders: a key to discovery and validation of novel analgesics.

Autor: Goldberg, YP, Pimstone, SN, Namdari, R, Price, N, Cohen, C, Sherrington, RP, Hayden, MR

Publikováno v: Clinical Genetics; Oct2012, Vol. 82 Issue 4, p367-373, 7p

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The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control.

Autor: Johnson JP Jr; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Focken T; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Karimi Tari P; Department of In Vivo Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Dube C; Department of In Vivo Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Goodchild SJ; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Andrez JC; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Bankar G; Department of In Vivo Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Burford K; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Chang E; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Chowdhury S; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Christabel J; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Dean R; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., de Boer G; Department of Compound Properties, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Dehnhardt C; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Gong W; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Grimwood M; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Hussainkhel A; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Jia Q; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Khakh K; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Lee S; Department of Compound Properties, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Li J; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Lin S; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Lindgren A; Department of Compound Properties, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Lofstrand V; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Mezeyova J; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Nelkenbrecher K; Department of In Vivo Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Shuart NG; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Sojo L; Department of Compound Properties, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Sun S; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Waldbrook M; Department of In Vivo Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Wesolowski S; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Wilson M; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Xie Z; Department of In Vitro Biology, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Zenova A; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Zhang W; Department of Chemistry, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Scott FL; Neurocrine Biosciences, San Diego, California, USA., Cutts AJ; Scientific Affairs, Xenon Pharmaceuticals, Inc, Burnaby, British Columbia, Canada., Sherrington RP; Executive Team, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Winquist R; Executive Team, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Cohen CJ; Executive Team, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada., Empfield JR; Executive Team, Xenon Pharmaceuticals Inc, Burnaby, British Columbia, Canada.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Oct; Vol. 181 (20), pp. 3993-4011. Date of Electronic Publication: 2024 Jun 24.