Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial

Autor: Allison R. Jones, Rakesh P. Patel, Marisa B. Marques, John P. Donnelly, Russell L. Griffin, Jean-Francois Pittet, Jeffrey D. Kerby, Shannon W. Stephens, Stacia M. DeSantis, John R. Hess, Henry E. Wang, John B. Holcomb, Charles E. Wade, Deborah J. del Junco, Erin E. Fox, Nena Matijevic, Jeanette Podbielski, Angela M. Beeler, Barbara C. Tilley, Sarah Baraniuk, Hongjian Zhu, Joshua Nixon, Roann Seay, Savitri N. Appana, Hui Yang, Michael O. Gonzalez, Lisa Baer, Yao-Wei W. Wang, Brittany S. Hula, Elena Espino, An Nguyen, Nicholas Pawelczyk, Kisha D. Arora-Nutall, Rishika Sharma, Jessica C. Cardenas, Elaheh Rahbar, Tyrone Burnett, David Clark, Gerald van Belle, Susanne May, Brian Leroux, David Hoyt, Judy Powell, Kellie Sheehan, Alan Hubbard, Adam P. Arkin, Jeanne Callum, Bryan A. Cotton, Laura Vincent, Timothy Welch, Tiffany Poole, Evan G. Pivalizza, Sam D. Gumbert, Yu Bai, James J. McCarthy, Amy Noland, Rhonda Hobbs, Eileen M. Bulger, Patricia Klotz, Lindsay Cattin, Keir J. Warner, Angela Wilson, David Boman, Nathan White, Andreas Grabinsky, Jennifer A. Daniel-Johnson, Mitchell J. Cohen, Rachael A. Callcut, Mary Nelson, Brittney Redick, Amanda Conroy, Marc P. Steurer, Preston C. Maxim, Eberhard Fiebig, Joanne Moore, Eireen Mallari, Peter Muskat, Jay A. Johannigman, Bryce R.H. Robinson, Richard D. Branson, Dina Gomaa, Christopher Barczak, Suzanne Bennett, Patricia M. Carey, Christopher N. Miller, Helen Hancock, Carolina Rodriguez, Kenji Inaba, Jay G. Zhu, Monica D. Wong, Michael Menchine, Kelly Katzberg, Sean O. Henderson, Rodney McKeever, Ira A. Shulman, Janice M. Nelson, Christopher W. Tuma, Cheryl Y. Matsushita, Thomas M. Scalea, Deborah M. Stein, Cynthia K. Shaffer, Christine Wade, Anthony V. Herrera, Seeta Kallam, Sarah E. Wade, Samuel M. Galvagno, Magali J. Fontaine, Janice M. Hunt, Rhonda K. Cooke, Timothy C. Fabian, Jordan A. Weinberg, Martin A. Croce, Suzanne Wilson, Stephanie Panzer-Baggett, Lynda Waddle-Smith, Sherri Flax, Karen J. Brasel, Pamela Walsh, David Milia, Allia Nelson, Olga Kaslow, Tom P. Aufderheide, Jerome L. Gottschall, Erica Carpenter, Terence O’Keeffe, Laurel L. Rokowski, Kurt R. Denninghoff, Daniel T. Redford, Deborah J. Novak, Susan Knoll, Patrick L. Bosarge, Albert T. Pierce, Carolyn R. Williams, Martin A. Schreiber, Jennifer M. Watters, Samantha J. Underwood, Tahnee Groat, Craig Newgard, Matthias Merkel, Richard M. Scanlan, Beth Miller, Sandro Rizoli, Homer Tien, Barto Nascimento, Sandy Trpcic, Skeeta Sobrian-Couroux, Marciano Reis, Adic Pérez, Susan E. Belo, Lisa Merkley, Connie Colavecchia

Publikováno v: Annals of Emergency Medicine. 73:650-661

Study objective The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion. Methods We analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0026999a5da70a2cfde26fa63c27e34b
https://doi.org/10.1016/j.annemergmed.2018.09.033

Optimizing COVID-19 testing capabilities and clinical management using pathology informatics

Autor: Michael J. Clare-Salzler, Mary Reeves, Kartikeya Cherabuddi, Maggie M Downey, Michael J Joshi-Guske, Nicole M. Iovine, Sherri Flax, Petr Starostik, Srikar Chamala, Siddardha Majety, Kimberly J. Newsom, Tanmay P. Lele

Publikováno v: JAMIA Open

Coronavirus disease 2019, first reported in China in late 2019, has quickly spread across the world. The outbreak was declared a pandemic by the World Health Organization on March 11, 2020. Here, we describe our initial efforts at the University of F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0b02d04c05d7f7fb7946610c89e9ed

Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial

Autor: Janice M. Nelson, Jeanette M. Podbielski, John R. Hess, Sarah Baraniuk, Ira A. Shulman, Veda Duncan, Deborah J. Novak, Marisa B. Marques, Rhonda K. Cooke, Jeannie Callum, Jerome L. Gottschall, Sandro Rizoli, Kenji Inaba, Richard M. Scanlan, John B. Holcomb, Barbara C. Tilley, Martin A. Schreiber, Eberhard W. Fiebig, Magali J. Fontaine, Jennifer A. Daniel-Johnson, Yu Bai, Erin E. Fox, Bryan A. Cotton, Patricia M. Carey, Sherri Flax

Publikováno v: Transfusion. 55:1331-1339

BACKGROUND The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical trial comparing survival after transfusion of two different blood component ratios for emergency resuscitation of traumatic massive hemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0882dca8e96b2abd69a7cff73db00f6e
https://doi.org/10.1111/trf.13098

What Are the Goals of Lipid Testing?

Autor: Sherri Flax, Neil S. Harris, William E. Winter

Publikováno v: The journal of applied laboratory medicine. 2(5)

Lipids can be measured for immediate diagnostic purposes in which a dyslipidemia is in the differential diagnosis of the patient's presenting complaint. For example, a fasting lipid profile (specifically including triglycerides) would be appropriate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef5df92a7d3d8cb65fa23c5318d99ca
https://pubmed.ncbi.nlm.nih.gov/33636878

ADAMTS13 Immunohistochemical Expression in Normal and Diseased Equine Tissues

Autor: Sherri Flax

Publikováno v: Blood. 134:4925-4925

ADAMTS13 is a metallopeptidase primarily synthesized in the liver. Its main function is to cleave von Willebrand factor (VWF) on the endothelial surface, and thus regulate platelet adhesion at the sites of vascular injury; VWF acts as a scaffold at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5ae9aee3d48a3dd9a4cbebb141757f2
https://doi.org/10.1182/blood-2019-127407