Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sherri Chubb"'
Autor:
William Plunkett, Walter Hittelman, Akira Matsuda, Peng Huang, Atsushi Azuma, Sherri Chubb, Yingjun Jiang, Yexiong Li, Ying Guo, Xiaojun Liu
Legends to Supplementary Figures and Table from Molecular Basis for G2 Arrest Induced by 2′-C-Cyano-2′-Deoxy-1-β-d-Arabino-Pentofuranosylcytosine and Consequences of Checkpoint Abrogation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641bdb4dcc4ce9ac9d9eccc6f51d38cf
https://doi.org/10.1158/0008-5472.22363677
https://doi.org/10.1158/0008-5472.22363677
Autor:
William Plunkett, Walter Hittelman, Akira Matsuda, Peng Huang, Atsushi Azuma, Sherri Chubb, Yingjun Jiang, Yexiong Li, Ying Guo, Xiaojun Liu
2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) is a nucleoside analogue with a novel mechanism of action that is currently being evaluated in clinical trials. Incorporation of CNDAC triphosphate into DNA and extension during re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7ec1291ca2833a2dbd3e4aa05c0bbb
https://doi.org/10.1158/0008-5472.c.6493833.v1
https://doi.org/10.1158/0008-5472.c.6493833.v1
Supplementary Figure 1 from Responses in Mantle Cell Lymphoma Cells to SNS-032 Depend on the Biological Context of Each Cell Line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bc2d5d6f51581dbeb5e764530aa714
https://doi.org/10.1158/0008-5472.22383392.v1
https://doi.org/10.1158/0008-5472.22383392.v1
SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7, and 9 that regulate the cell cycle and transcription. Our studies in indolent primary chronic lymphocytic leukemia cells showed that SNS-032 inhibited transcription, diminished the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831c76120ba701e4d2e0d14b8a5a893
https://doi.org/10.1158/0008-5472.c.6500522
https://doi.org/10.1158/0008-5472.c.6500522
Autor:
Peng Huang, Walter N. Hittelman, William Plunkett, Atsushi Azuma, Xiaojun Liu, Ying Guo, Sherri Chubb, Akira Matsuda, Yingjun Jiang, Yexiong Li
Publikováno v:
Cancer Research. 65:6874-6881
2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) is a nucleoside analogue with a novel mechanism of action that is currently being evaluated in clinical trials. Incorporation of CNDAC triphosphate into DNA and extension during re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8db56cd0ec742e8a25de296403a4c
https://doi.org/10.1158/0008-5472.can-05-0288
https://doi.org/10.1158/0008-5472.can-05-0288
Autor:
L. E. Robertson, Raymond E. Meyn, Richard J. Ford, Sherri Chubb, Michael D. Story, Walter N. Hittelman, William Plunkett
Publikováno v:
Blood. 81:143-150
2-Chloro-2′-deoxyadenosine (CldAdo) and 9-beta-D-arabinosyl-2- fluoroadenine (F-ara-A) have shown marked activity in the treatment of indolent lymphoid malignancies. Based on the susceptibility of various lymphocyte populations to apoptosis, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e4e9ef1d3215461e5201c2e588092a
https://doi.org/10.1182/blood.v81.1.143.bloodjournal811143
https://doi.org/10.1182/blood.v81.1.143.bloodjournal811143
Publikováno v:
Cancer research. 70(16)
SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7, and 9 that regulate the cell cycle and transcription. Our studies in indolent primary chronic lymphocytic leukemia cells showed that SNS-032 inhibited transcription, diminished the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c849217f548e0648bb25788348fde5e6
https://pubmed.ncbi.nlm.nih.gov/20663900
https://pubmed.ncbi.nlm.nih.gov/20663900
Autor:
Varsha Gandhi, William G. Wierda, Rong Chen, Judith A. Fox, Rachael E. Hawtin, Michael J. Keating, Sherri Chubb, William Plunkett
Publikováno v:
Blood. 113(19)
Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91da498228f50c317539db8793d1eccc
https://pubmed.ncbi.nlm.nih.gov/19234140
https://pubmed.ncbi.nlm.nih.gov/19234140
Publikováno v:
The Journal of biological chemistry. 265(27)
The action of 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) on DNA synthesis was evaluated both in whole cells and in vitro. 9-beta-D-Arabinofuranosyl-2-fluoroadenine was converted to its 5'-triphosphate 9-beta-D-arabinofuranosyl-2-fluoroadenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3b59d60aff2ceb7a6a638ae885c87e
https://pubmed.ncbi.nlm.nih.gov/1697861
https://pubmed.ncbi.nlm.nih.gov/1697861
Autor:
Billie Nowak, J. S. Kroina, William Plunkett, S. Mineishi, Sherri Chubb, L. W. Hertel, C. S. Grossmana
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 8:951-955
2′,2′-Difluoro analogs of deoxyadenosine (dFdA) and deoxyguanosine (dFdG) were synthesized. The in vitro toxicity and metabolism of dFdA and dFdG was studied in human leukemia cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d6c68fa3ca06dc8677dbcec544cc71
https://doi.org/10.1080/07328318908054252
https://doi.org/10.1080/07328318908054252