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Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta

Autor: Akhtar, R, Graham, HK, Derby, B, Sherratt, MJ, Trafford, AW, Chadwick, RS, Gavara, N

Publikováno v: Journal of the Mechanical Behavior of Biomedical Materials
Akhtar, R, Graham, H, Derby, B, Sherratt, M, Trafford, A, Chadwick, R & Gavara, N 2016, ' Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta ', Journal of the Mechanical Behaviour of Materials, vol. 64, pp. 10-17 . https://doi.org/10.1016/j.jmbbm.2016.07.018
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

Age-related aortic stiffening is associated with cardiovascular diseases such as heart failure. The mechanical functions of the main structural components of the aorta, such as collagen and elastin, are determined in part by their organisation at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::79235e35ddb718db0ade9e0657c050eb
http://europepmc.org/articles/PMC5020410

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A Review of Techniques for Visualising Soft Tissue Microstructure Deformation and Quantifying Strain Ex Vivo

Autor: Disney, CM, Lee, PD, Hoyland, JA, Sherratt, MJ, Bay, BK

Publikováno v: Disney, C, Lee, P, Hoyland, J, Sherratt, M & Bay, B K 2018, ' A Review of Techniques for Visualising Soft Tissue Microstructure Deformation and Quantifying Strain Ex Vivo ', Journal of Microscopy . https://doi.org/10.1111/jmi.12701

Many biological tissues have a complex hierarchical structure allowing them to function under demanding physiological loading conditions. Structural changes caused by ageing or disease can lead to loss of mechanical function. Therefore, it is necessa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b46777442897348650b97d2c338c973c
https://doi.org/10.1111/jmi.12701

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Visualising the 3D microstructure of stained and native intervertebral discs using X-ray microtomography

Autor: Disney, CM, Madi, K, Bodey, AJ, Lee, PD, Hoyland, JA, Sherratt, MJ

Publikováno v: Disney, C, Madi, K, A.J., B, Lee, P, Hoyland, J & Sherratt, M 2017, ' Visualising the 3D microstructure of stained and native intervertebral discs using X-ray microtomography ', Scientific Reports, vol. 7, 16279 . https://doi.org/10.1038/s41598-017-16354-w
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Intervertebral disc degeneration (IVDD) is linked to low back pain. Microstructural changes during degeneration have previously been imaged using 2D sectioning techniques and 3D methods which are limited to small specimens and prone to inducing artef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b8abdbf2a5954c4d3970567f327d7486
https://doi.org/10.1038/s41598-017-16354-w

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Localized micro- and nano-scale remodelling in the diabetic aorta

Autor: Akhtar, R, Cruickshank, JK, Zhao, X, Walton, LA, Gardiner, NJ, Barrett, SD, Graham, HK, Derby, B, Sherratt, MJ

Publikováno v: Acta Biomaterialia
Akhtar, R, Cruickshank, J K, Zhao, X, Walton, L A, Gardiner, N J, Barrett, S D, Graham, H K, Derby, B & Sherratt, M J 2014, ' Localized micro-and nano-scale remodelling in the diabetic aorta ', Acta Biomaterialia, vol. 10, no. 11, pp. 4843-4851 . https://doi.org/10.1016/j.actbio.2014.07.001

Graphical abstract
Diabetes is strongly associated with cardiovascular disease, but the mechanisms, structural and biomechanical consequences of aberrant blood vessel remodelling remain poorly defined. Using an experimental (streptozotocin, STZ)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36ab89b3f64bb225b10fcb241ef40a3d
http://europepmc.org/articles/PMC4199142

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Morphological characterisation of unstained and intact tissue micro-architecture by X-ray computed micro- and nano-tomography

Autor: Walton, LA, Bradley, RS, Withers, PJ, Newton, VL, Watson, REB, Austin, C, Sherratt, MJ

Publikováno v: Walton, L A, Bradley, R S, Withers, P J, Newton, V L, Watson, R E B, Austin, C & Sherratt, M J 2015, ' Morphological characterisation of unstained and intact tissue micro-architecture by X-ray computed micro-and nano-tomography ', Scientific Reports, vol. 5, 10074 . https://doi.org/10.1038/srep10074

Characterisation and quantification of tissue structures is limited by sectioning-induced artefacts and by the difficulties of visualising and segmenting 3D volumes. Here we demonstrate that, even in the absence of X-ray contrast agents, X-ray comput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f9db791753f3a55ed27ef79e873c706f
http://www.scopus.com/inward/record.url?scp=84929359039&partnerID=8YFLogxK

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