Výsledky vyhledávání - "Sherona Sirkisoon"

NEDD4 degrades TUSC2 to promote glioblastoma progression

Autor: Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo

Publikováno v: Cancer Lett

Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d1602303d3b2100122e04793288c7
https://doi.org/10.1016/j.canlet.2022.01.029

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Data from Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44

Autor: Hui-Wen Lo, Waldemar Debinski, Kounosuke Watabe, Stephen B. Tatter, Glenn J. Lesser, Michael D. Chan, Boris C. Pasche, Dongqin Zhu, Sherona Sirkisoon, Richard L. Carpenter, Tadas K. Rimkus

The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b98059fed05947ea6aa0b63eb4ba3805
https://doi.org/10.1158/0008-5472.c.6510272.v1

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Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

Autor: Guanwen Wang, Juan Wang, Antao Chang, Dongmei Cheng, Shan Huang, Dan Wu, Sherona Sirkisoon, Shuang Yang, Hui-Kuan Lin, Hui-Wen Lo, Rong Xiang, Peiqing Sun

Publikováno v: Oncogene

While mechanisms for metastasis were extensively studied in cancer cells from patients with detectable tumors, pathways underlying metastatic dissemination from early lesions before primary tumors appear are poorly understood. Her2 promotes breast ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de6be6caba7d51ec5de3eac6ec9f4b
http://europepmc.org/articles/PMC7680376

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Abstract 2433: Targeting tGLI1 pharmacologically as a new therapeutic strategy for breast cancer brain metastases

Autor: Daniel Doheny, Sara Manore, Grace L. Wong, Dongqin Zhu, Sherona Sirkisoon, Marlyn Anguelov, Noah R. Augayo, Angelina T. Regua, Anderson Cox, Cristina Furdui, Terrence Smalley, Alexandra Thomas, Adrianna Masters, Roy E. Strowd, Hui-Wen Lo

Publikováno v: Cancer Research. 82:2433-2433

Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months after diagnosis. Novel agents that act on targetable driver mutations (EGFR, PI3K, etc.) and penetrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8517d981289dbc699cc1614dbc6ff842
https://doi.org/10.1158/1538-7445.am2022-2433

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Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer

Autor: Richard L. Carpenter, Kounosuke Watabe, Guangxu Jin, Hui-Wen Lo, Tadas Rimkus, Alexandria Harrison, Ashley Anderson, Sherona Sirkisoon, Allison M. Lange

Publikováno v: Oncogene

Signal transducer and activator of transcription 3 (STAT3), glioma oncogene homolog 1 (GLI1), and truncated GLI1 (tGLI1) are oncogenic transcription factors playing important roles in breast cancer. tGLI1 is a gain-of-function GLI1 isoform. Whether S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aefd3f3901a47e43ad4c2940736af9
https://doi.org/10.1038/s41388-018-0132-4

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Abstract 2866: Truncated glioma-associated oncogene homolog 1 (tGLI1) is an actionable therapeutic target in breast cancer brain metastases

Autor: Hui-Wen Lo, Kounosuke Watabe, Dongqin Zhu, Alexandra Thomas, Adrianna H. Masters, Fei Xing, Marlyn Anguelov, Noah R. Aguayo, Tadas Rimkus, Daniel Doheny, Linda J. Metheny-Barlow, Sherona Sirkisoon, Roy E. Strowd, Sara G. Manore

Publikováno v: Cancer Research. 81:2866-2866

Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months following diagnosis. Current standard of care options for BCBM include stereotactic radiosurgery, who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79430d0291bc3b5c23c58dca3d2633b7
https://doi.org/10.1158/1538-7445.am2021-2866

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First Biochemical Characterization of a Methylcitric Acid Cycle from Bacillus subtilis Strain 168

Autor: Grant Hardesty, Jennifer S. Doyle, Brittany E. Kiel, Natalie E. Hage, Amy L. Quattlebaum, Sherona Sirkisoon, Jason J. Reddick, Rejwi Acharya Dahal, William T. Booth, Sydney L. H. Adams, Victoria G. Meadows, Suzette N. Mills

Publikováno v: Biochemistry. 56:5698-5711

The genome of Bacillus subtilis strain 168 contains the mother cell metabolic gene (mmg) operon that encodes homologues from the methylcitric acid cycle. We showed that the three genes, mmgDE and yqiQ(mmgF), provide three of the five steps of the met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5e23920876aaafa3bc63e6a2bc3b2e
https://doi.org/10.1021/acs.biochem.7b00778

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