Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Sherman M, Weissman"'
Autor:
Yanfang Lu, Miao Liu, Jennifer Yang, Sherman M. Weissman, Xinghua Pan, Samuel G. Katz, Siyuan Wang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet a more systematic investigation into the microenvironment regulation of hematopoiesis in fetal liver is necessary. Here we investigate the spatial organ
Externí odkaz:
https://doaj.org/article/848c5a89397648aa94a748cc431000cb
Autor:
Peng Gong, Hua Wang, Jingsong Zhang, Yudong Fu, Zhengmao Zhu, Jinmiao Wang, Yu Yin, Haiying Wang, Zhongcheng Zhou, Jiao Yang, Linlin Liu, Mo Gou, Ming Zeng, Jinghua Yuan, Feng Wang, Xinghua Pan, Rong Xiang, Sherman M. Weissman, Feng Qi, Lin Liu
Publikováno v:
Translational Oncology, Vol 12, Iss 9, Pp 1164-1176 (2019)
Telomere length maintenance is essential for cell proliferation, which is particularly prominent in cancer. We validate that the primary colorectal tumors exhibit heterogeneous telomere lengths but mostly (90%) short telomeres relative to normal tiss
Externí odkaz:
https://doaj.org/article/73247c82176745398bb000f1ac67aae8
Autor:
Hua Wang, Peng Gong, Tong Chen, Shan Gao, Zhenfeng Wu, Xiaodong Wang, Jie Li, Sadie L. Marjani, José Costa, Sherman M. Weissman, Feng Qi, Xinghua Pan, Lin Liu
Publikováno v:
Advanced Science, Vol 8, Iss 8, Pp n/a-n/a (2021)
Abstract Cancer stem cells (CSCs) presumably contribute to tumor progression and drug resistance, yet their definitive features have remained elusive. Here, simultaneous measurement of telomere length and transcriptome in the same cells enables syste
Externí odkaz:
https://doaj.org/article/4830b0aa66d54c12b986d7a2fd7aa513
Autor:
Xianglong Zhang, Ying Zhang, Xiaowei Zhu, Carolin Purmann, Michael S. Haney, Thomas Ward, Arineh Khechaduri, Jie Yao, Sherman M. Weissman, Alexander E. Urban
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organiza
Externí odkaz:
https://doaj.org/article/e9aab59abbe142e29443cfd1acc2965a
Autor:
Liyao Mai, Zebin Wen, Yulong Zhang, Yu Gao, Guanchuan Lin, Zhiwei Lian, Xiang Yang, Jingjing Zhou, Xianwei Lin, Chaochao Luo, Wanwan Peng, Caiming Chen, Duolian Liu, Junxiao Zhang, Sadie L. Marjani, Qian Tao, Xuedong Wu, Sherman M. Weissman, Xinghua Pan
DNA methylation is essential for a wide variety of biological processes, yet the development of a highly efficient and robust technology remains a challenge for routine single-cell analysis. We developed a multiplex scalable single-cell reduced repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dac6b2f02db73595a7f30ba47d414e7
https://doi.org/10.1101/2023.05.22.541674
https://doi.org/10.1101/2023.05.22.541674
Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family
Autor:
Eriona Hysolli, Yoshiaki Tanaka, Juan Su, Kun-Yong Kim, Tianyu Zhong, Ralf Janknecht, Xiao-Ling Zhou, Lin Geng, Caihong Qiu, Xinghua Pan, Yong-Wook Jung, Jijun Cheng, Jun Lu, Mei Zhong, Sherman M. Weissman, In-Hyun Park
Publikováno v:
Stem Cell Reports, Vol 7, Iss 1, Pp 43-54 (2016)
Reprogramming to pluripotency after overexpression of OCT4, SOX2, KLF4, and MYC is accompanied by global genomic and epigenomic changes. Histone modification and DNA methylation states in induced pluripotent stem cells (iPSCs) have been shown to be h
Externí odkaz:
https://doaj.org/article/3fded01f77c44b88ada485492b861077
Autor:
Jijun Cheng, Christine A. Roden, Wen Pan, Shu Zhu, Anna Baccei, Xinghua Pan, Tingting Jiang, Yuval Kluger, Sherman M. Weissman, Shangqin Guo, Richard A. Flavell, Ye Ding, Jun Lu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The interrogation of noncoding regions of the genome with CRISPR strategies requires dense and, ideally, inexpensive libraries to ensure coverage and customisation. Here the authors present 'Molecular Chipper' that uses fragmentation to generate guid
Externí odkaz:
https://doaj.org/article/18430b661da84ddb83ebbefbef3dc891
Publikováno v:
PeerJ, Vol 5, p e2888 (2017)
Single-cell RNA-Sequencing (scRNA-Seq) is a fast-evolving technology that enables the understanding of biological processes at an unprecedentedly high resolution. However, well-suited bioinformatics tools to analyze the data generated from this new t
Externí odkaz:
https://doaj.org/article/3d667e316ee549fa8c518c270d742270
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(8)
Single-cell sequencing is widely used in biological and medical studies. However, its application with multiple samples is hindered by inefficient sample processing, high experimental costs, ambiguous identification of true single cells, and technica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbe4dfb2115e505767115f1242432ec
https://pubmed.ncbi.nlm.nih.gov/35927335
https://pubmed.ncbi.nlm.nih.gov/35927335
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14335
Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by a unique BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) were developed to target the BCR-ABL oncoprotein, inhibiting its abnormal kinase activity. TKI treatments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2068fa69160f59ee06ef0c53dc96f3
https://doi.org/10.3390/ijms232214335
https://doi.org/10.3390/ijms232214335