Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sherman Ku"'
Autor:
Nina B. Reese, Sherman Ku
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss , Pp 269-280 (2021)
Current methods for stably expressing recombinant protein therapeutics in CHO cells often rely on random or semi-random genomic integration events which result in a widely heterogeneous cell population. Consequently, a significant portion of cell lin
Externí odkaz:
https://doaj.org/article/2ff1ea56e0ab4582a3e41486760a50d4
Autor:
Jiun I. Lai, Joel M. Gottesfeld, Christian A. Olsen, M. Reza Ghadiri, Ana Montero, Chris J. Vickers, Luke J. Leman, Sherman Ku
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3289-3293
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is caused by inactivating mutations in the Survival of motor neuron 1 (SMN1) gene, resulting in decreased SMN protein expression. Humans possess a paralog gene, SMN2,
Autor:
Jeanne F. Loring, Wenyan Miao, Elisabetta Soragni, Myriam Rai, Pablo Penalver, Joseph C. Madara, David Jacoby, Joel M. Gottesfeld, Massimo Pandolfo, Stefania Federica De Mercanti, Jintang Du, Filomena Longo, James R. Rusche, Melinda O'Connor, Antonio Piga, Kristopher L. Nazor, Sherman Ku, Marco Iudicello, Anton Maximov, L. Durelli, Marinella Clerico, Erica Campau
Publikováno v:
Annals of Neurology. 76:489-508
Friedreich ataxia (FRDA; Online Mendelian Inheritance in Man database #229300) is an autosomal recessive inherited degenerative disorder affecting the nervous system and the heart, with a prevalence of approximately 2 to 3 in 100,000 in North America
Autor:
Ben W. Gregor, Anu Jayabalu, John W. Phillips, Nadiya V. Shapovalova, John K. Mich, Margaret A. Fuqua, Leah J. Tait, Carol L. Thompson, N. Kiet Ngo, Samuel Melton, Heather Mulholland, Shuyuan Yao, Joshua S. Grimley, Anne-Rachel F. Krostag, Sharad Ramanathan, Chaoyang Ye, Ajamete Kaykas, Vilas Menon, Angelique M. Nelson, Boaz P. Levi, Ian A. Glass, Sherman Ku, Elliot R. Thomsen, Yanling Wang, Rebecca D. Hodge, Soraya I. Shehata, Ryan C. May, Zizhen Yao, Leon Furchtgott, Refugio A. Martinez, Michael W. Smith, Susan Bort
Publikováno v:
Cell stem cell. 20(1)
During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal analyses to reveal lineage trees and molecular signals underlying early
Autor:
Uli Schmidt, Louise C. Laurent, Robert Morey, Hans S. Keirstead, Vasiliy Galat, Ruslan Semechkin, Jeanne F. Loring, Andrew J. Schork, Caroline M. Nievergelt, Julie V. Harness, Andrew L. Laslett, Ileana Slavin, Ron Shamir, Franz-Josef Müller, Sunray Lee, Hyun Sook Park, Maria J. Barrero, Ha Tran, Marina Martynova, Igor Ulitsky, Candace L. Lynch, Joel M. Gottesfeld, Juan Carlos Izpisua Belmonte, Sherman Ku, Charles E. Murry
Publikováno v:
Cell Stem Cell. 8(1):106-118
SummaryGenomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on 186 pluripotent and 119 nonpluripotent samples. We report a
Autor:
Gabriele Varani, Sandra Shannon, Sherman Ku, Shuyuan Yao, Hannele Ruohola-Baker, Yu Chen, Henrik Sperber, Alan Beem, Ross D. Jones, Pratyusha Banik
microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2579ee45c985ae522d811ff3512e4eed
https://europepmc.org/articles/PMC3988564/
https://europepmc.org/articles/PMC3988564/
Autor:
Elisabetta Soragni, Joel M. Gottesfeld, Jintang Du, Peter B. Dervan, Erica Campau, Sherman Ku, James W. Puckett
The genetic mutation in Friedreich ataxia (FRDA) is a hyperexpansion of the triplet-repeat sequence GAA·TTC within the first intron of the FXN gene. Although yeast and reporter construct models for GAA·TTC triplet-repeat expansion have been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4780136650c5b1ec132559c7f052ec
https://resolver.caltech.edu/CaltechAUTHORS:20120927-144905197
https://resolver.caltech.edu/CaltechAUTHORS:20120927-144905197
Autor:
Urszula Polak, Joel M. Gottesfeld, Marek Napierala, Sherman Ku, Sharon Y.R. Dent, Calley L. Hirsch
Publikováno v:
Scopus-Elsevier
Herein we present a protocol of reprogramming human adult fibroblasts into human induced pluripotent stem cells (hiPSC) using retroviral vectors encoding Oct3/4, Sox2, Klf4 and c-myc (OSKM) in the presence of sodium butyrate (1-3). We used this metho
In this chapter, methods are provided for studying chromatin dynamics, the binding of modified histones to specific genes in hPSCs and their derivatives. hPSC chromatin is thought to be more “open” and hPSCs are characterized by an expression pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd1a04cb45a0170638d78c586660e665
https://doi.org/10.1016/b978-0-12-385473-5.00019-9
https://doi.org/10.1016/b978-0-12-385473-5.00019-9
Autor:
Lars Ährlund-Richter, Gulsah Altun, Isao Asaka, Marina Bibikova, Mathew Blurton-Jones, Francesca Boscolo, Stefan Braam, Oliver Brustle, Kevin S. Carbajal, Jessica Cedervall, Lu Chen, Jonathan Chesnut, Cleo Choong, Ronald Coleman, Hun Chy, Jeremy M. Crook, Cheryl Dambrot, Ivan Damjanov, Richard Davis, Mary Devereaux, Mahesh Dodla, Biljana Dumevska, Eyitayo S. Fakunle, Lisa A. Flanagan, Ibon Garitaonandia, Karin Gertow, Victoria Glenn, Johanna E. Goldmann, Joel M. Gottesfeld, Jason Gustin, Sangyoon Han, Nick Hannan, Yvonne Hoang, Natalie Hobson, Marlys Houck, Hans S. Keirstead, Philip Koch, Sherman Ku, Frank M. LaFerla, Uma Lakshmipathy, Jack Lambshead, Thomas E. Lane, Andrew L. Laslett, Louise C. Laurent, Michael Lenz, Trevor R. Leonardo, Tianjian Li, Pauline Lieu, Qiuyue Liu, Ying Liu, Jeanne F. Loring, Mai X. Luong, Kim Ly, Candace L. Lynch, Ian Lyons, Steven McArthur, Robert E. Morey, Franz-Josef Müller, Christine Mummery, Kristopher L. Nazor, Joy L. Nerhus, Elizabeth Ng, Kyle S. Nickey, Gabriel I. Nistor, Jamison L. Nourse, Carmel O’Brien, Theo Palmer, Mark L. Rohrbaugh, Oliver Z Pedersen, Suzanne E. Peterson, Mahendra Rao, Julia Schaft, John P. Schell, Ulrich Schmidt, Bernhard M. Schuldt, Philip H. Schwartz, Jason Sharp, James Shen, Ronald Simon, Ileana Slavin, Kelly P. Smith, Elisabetta Soragni, Glyn Stacey, Rathi D. Thiagarajan, Thomas Touboul, Bhaskar Thyagarajan, Ha T. Tran, Ludovic Vallier, Cathelijne Van Den Berg, Yu-Chieh Wang, Dorien Ward-van Oostwaard, Jason Weinger, Shinya Yamanaka, Xianmin Zeng, Qi Zhou, Boback Ziaeian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8323bf593987afb45d9593aa99b936b
https://doi.org/10.1016/b978-0-12-385473-5.00042-4
https://doi.org/10.1016/b978-0-12-385473-5.00042-4