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pro vyhledávání: '"Sherman Bloom"'
Autor:
Sherman Bloom
Publikováno v:
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 4(1)
Autor:
Sherman Bloom, Pamarthi F. Mohan
Publikováno v:
Cardiovascular Pathology. 6:287-291
Factors that determine the wide variation in the severity of isoproterenol-induced myocardial necrosis (ISO-MN) are numerous and poorly defined. We have investigated the role of age, body weight, food intake, and genetic strain differences on vulnera
Autor:
Sherman Bloom, Virginia G. Lockard
Publikováno v:
Journal of Molecular and Cellular Cardiology. 25:303-309
Excessive stretch of heart muscle is thought to be a determinant of myocardial hypertrophy. Because cell shape and nuclear shape are closely coupled in cardiac myocytes, we hypothesize that excessive stretch causes physical deformation of the nucleus
Autor:
Sherman Bloom, Manfred Brust, Burton M. Altura, Bella T. Altura, Jerome G. Stempak, Randall L. Barbour
Publikováno v:
Proceedings of the National Academy of Sciences. 87:1840-1844
In this study, we have examined the effects of variation in dietary Mg on the atherogenic process. Oral supplementation of rabbits fed a high cholesterol diet (1% or 2%) with the Mg salt magnesium aspartate hydrochloride (Magnesiocard) (i) lowers the
Autor:
Pamarthi F. Mohan, Sherman Bloom
Publikováno v:
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 8(5)
The cardiotoxic effect of isoproterenol (ISO) is associated with, and possibly due to, calcium overload. Prior work suggests that calcium entry into cardiac myocytes after ISO administration occurs in two phases: an early rapid phase, followed by a s
Publikováno v:
Journal of molecular and cellular cardiology. 28(10)
Excessive stretching of the myocardium leads to hypertrophy, but how the stretch message is communicated to hypertrophy-initiating genes is unknown. Candidates hypothesized as couplers of physical stretch to growth initiation include neural and hormo
Publikováno v:
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 1(2)
Chronic magnesium deficiency is associated with injury of heart muscle, blood vessels, and neuronal tissue. Despite its clinical significance, the mechanism of magnesium deficiency-induced damage remains unclear. The myocardial necrosis induced by in
Publikováno v:
Life Sciences. 20:1913-1922
The relative importance of heart mitochondria in regulating intracellular [Ca 2+ ] in cardiac muscle is controversial. In a new approach to the question, we have measured the energy-linked 45 Ca uptake of an unusual myocardial tissue preparation in w
Autor:
Sherman Bloom
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 514:206-212
Beating hyperpermeable myocardial fragments, suspended in fresh medium, show a Ca uptake rate which greatly exceeds the release rate. Under these conditions, Ca influx and contraction frequeny co-vary with temperature. Ca efflux, however, is not temp
Autor:
Bruce V. Stadel, Sherman Bloom, Beverly M. Calkins, Carol Maliza, Roland L. Phillips, Ilene Rosin, Jorge C. Rios, Paul D. Stolley, Richard B. Shekelle, Milton Terris, Susan S. Ellenberg, Dean E. Krueger, David C. Nolan, Kim M. Spector
Publikováno v:
American Journal of Epidemiology. 111:655-674
The association between use of oral contraceptives (OC) and death from myocardial infarction (MI) in young women was investigated in a collaborative case-control study conducted in the five largest metropolitan areas in the US. Potential cases were i