Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Shermali Gunawardena"'
Autor:
Shermali Gunawardena
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 197-198 (2025)
Externí odkaz:
https://doaj.org/article/1b900e28cebd429282ff79637ccd757a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these pro
Externí odkaz:
https://doaj.org/article/3a87d62ef394410fbc29238973d778da
Publikováno v:
Cells, Vol 12, Iss 19, p 2406 (2023)
Mitochondrial dysfunction has been reported in many Huntington’s disease (HD) models; however, it is unclear how these defects occur. Here, we test the hypothesis that excess pathogenic huntingtin (HTT) impairs mitochondrial homeostasis, using Dros
Externí odkaz:
https://doaj.org/article/285104535e204b4eb1dd66081bed4af3
Autor:
Thomas J. Krzystek, Rupkatha Banerjee, Layne Thurston, JianQiao Huang, Kelsey Swinter, Saad Navid Rahman, Tomas L. Falzone, Shermali Gunawardena
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-16 (2021)
Abstract Mitochondria are highly dynamic organelles with strict quality control processes that maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated by dynamin related GTPase protein (DRP1) and mitofusins (MFN), t
Externí odkaz:
https://doaj.org/article/4ef3ab4bdd874811bcfea7ca9e7a30a2
Autor:
Joseph A. White, Thomas J. Krzystek, Hayley Hoffmar-Glennon, Claire Thant, Katherine Zimmerman, Gary Iacobucci, Julia Vail, Layne Thurston, Saad Rahman, Shermali Gunawardena
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract Huntington’s disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT ha
Externí odkaz:
https://doaj.org/article/224ce975c7d5489eb06e9d6481238e8d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Proper transport of the Parkinson’s disease (PD) protein, α-synuclein (α-syn), is thought to be crucial for its localization and function at the synapse. Previous work has shown that defects in long distance transport within narrow caliber axons
Externí odkaz:
https://doaj.org/article/e1d853fc0f2a4abeab6867da0491aa5a
Autor:
Gary J Iacobucci, Noura Abdel Rahman, Aida Andrades Valtueña, Tapan Kumar Nayak, Shermali Gunawardena
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97237 (2014)
Efficient intracellular transport is essential for healthy cellular function and structural integrity, and problems in this pathway can lead to neuronal cell death and disease. To spatially and temporally evaluate how transport defects are initiated,
Externí odkaz:
https://doaj.org/article/313a1616adf84239b2f9e9e1608196c6
Autor:
Min Jung Kang, Timothy J Hansen, Monique Mickiewicz, Tadeusz J Kaczynski, Samantha Fye, Shermali Gunawardena
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104617 (2014)
Formation of new synapses or maintenance of existing synapses requires the delivery of synaptic components from the soma to the nerve termini via axonal transport. One pathway that is important in synapse formation, maintenance and function of the Dr
Externí odkaz:
https://doaj.org/article/ce226dc0f9564274b3c7ff28601e4546
Publikováno v:
Marine Drugs, Vol 14, Iss 5, p 102 (2016)
Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally loca
Externí odkaz:
https://doaj.org/article/7d8efb2ada6a46f89773e683c50f7c1c
Autor:
Farda Barandeh, Phuong-Lan Nguyen, Rajiv Kumar, Gary J Iacobucci, Michelle L Kuznicki, Andrew Kosterman, Earl J Bergey, Paras N Prasad, Shermali Gunawardena
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29424 (2012)
The application of nanotechnology in biological research is beginning to have a major impact leading to the development of new types of tools for human health. One focus of nanobiotechnology is the development of nanoparticle-based formulations for u
Externí odkaz:
https://doaj.org/article/85ef5c0d7d82403d890668b1644dbc49