Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Shermali Gunawardena"'
Autor:
Shermali Gunawardena
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 197-198 (2025)
Externí odkaz:
https://doaj.org/article/1b900e28cebd429282ff79637ccd757a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these pro
Externí odkaz:
https://doaj.org/article/3a87d62ef394410fbc29238973d778da
Publikováno v:
Cells, Vol 12, Iss 19, p 2406 (2023)
Mitochondrial dysfunction has been reported in many Huntington’s disease (HD) models; however, it is unclear how these defects occur. Here, we test the hypothesis that excess pathogenic huntingtin (HTT) impairs mitochondrial homeostasis, using Dros
Externí odkaz:
https://doaj.org/article/285104535e204b4eb1dd66081bed4af3
Autor:
Thomas J. Krzystek, Rupkatha Banerjee, Layne Thurston, JianQiao Huang, Kelsey Swinter, Saad Navid Rahman, Tomas L. Falzone, Shermali Gunawardena
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-16 (2021)
Abstract Mitochondria are highly dynamic organelles with strict quality control processes that maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated by dynamin related GTPase protein (DRP1) and mitofusins (MFN), t
Externí odkaz:
https://doaj.org/article/4ef3ab4bdd874811bcfea7ca9e7a30a2
Autor:
Joseph A. White, Thomas J. Krzystek, Hayley Hoffmar-Glennon, Claire Thant, Katherine Zimmerman, Gary Iacobucci, Julia Vail, Layne Thurston, Saad Rahman, Shermali Gunawardena
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract Huntington’s disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT ha
Externí odkaz:
https://doaj.org/article/224ce975c7d5489eb06e9d6481238e8d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Proper transport of the Parkinson’s disease (PD) protein, α-synuclein (α-syn), is thought to be crucial for its localization and function at the synapse. Previous work has shown that defects in long distance transport within narrow caliber axons
Externí odkaz:
https://doaj.org/article/e1d853fc0f2a4abeab6867da0491aa5a
Autor:
Thomas J. Krzystek, Joseph A. White, Rasika Rathnayake, Layne Thurston, Hayley Hoffmar-Glennon, Yichen Li, Shermali Gunawardena
Publikováno v:
Autophagy. 19:1199-1220
Atg5: Autophagy-related 5; Atg8a: Autophagy-related 8a; AL: autolysosome; AP: autophagosome; BAF1: bafilomycin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ddd2fe579cbbcc15cd80e94d123234
https://doi.org/10.1080/15548627.2022.2119351
https://doi.org/10.1080/15548627.2022.2119351
Publikováno v:
Development
It is more than 25 years since the discovery that kinesin 1 is phosphorylated by several protein kinases. However, fundamental questions still remain as to how specific protein kinase(s) contribute to particular motor functions under physiological co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80fb53d75e99c95a3419d0e252a769f
https://doi.org/10.1242/dev.199866
https://doi.org/10.1242/dev.199866
Autor:
Shermali Gunawardena, Rupkatha Banerjee, Layne Thurston, JianQiao Huang, Thomas J. Krzystek, Kelsey Swinter, Tomás L. Falzone, Saad Navid Rahman
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Mitochondria are highly dynamic organelles with strict quality control processes that maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated by dynamin related GTPase protein (DRP1) and mitofusins (MFN), together w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87df81425268dc6b9d7ec9f749745e29
https://doi.org/10.1038/s41419-021-04046-3
https://doi.org/10.1038/s41419-021-04046-3
Autor:
Timothy J. Hansen, Bhasirie Thuamsang, Joseph A. White, Rupkatha Banerjee, Claire N. Thant, Shermali Gunawardena
Publikováno v:
Apoptosis. 24:341-358
High levels of oxidative stress is detected in neurons affected by many neurodegenerative diseases, including Huntington’s disease (HD). Many of these diseases also show neuronal cell death and axonal transport defects. While nuclear inclusions/acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8f836c63a17768ab7c26003ec008d0
https://doi.org/10.1007/s10495-019-01520-4
https://doi.org/10.1007/s10495-019-01520-4