Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shermaine Mitchell-Ryan"'
Autor:
Cris Kamperschroer, Brendon Frank, Caroline Genell, Hervé Lebrec, Shermaine Mitchell-Ryan, Brigitte Molinier, Courtni Newsome, Marie-Soleil Piche, Daniel Weinstock, Mark Collinge, Wendy Freebern, Daniel Rubio
Publikováno v:
Journal of Immunotoxicology, Vol 20, Iss 1 (2023)
AbstractCytotoxic T-lymphocytes (CTL) are a subset of T-cells that play a critical role in protecting against intracellular infections and cancer, and have the ability to identify and kill infected or transformed cells expressing non-self peptides as
Externí odkaz:
https://doaj.org/article/e52be90ce9a64f71b5de2941c8e295cf
Autor:
Ronald van Ree, Dexter Sapiter Ballerda, M. Cecilia Berin, Laurent Beuf, Alexander Chang, Gabriele Gadermaier, Paul A. Guevera, Karin Hoffmann-Sommergruber, Emir Islamovic, Liisa Koski, John Kough, Gregory S. Ladics, Scott McClain, Kyle A. McKillop, Shermaine Mitchell-Ryan, Clare A. Narrod, Lucilia Pereira Mouriès, Syril Pettit, Lars K. Poulsen, Andre Silvanovich, Ping Song, Suzanne S. Teuber, Christal Bowman
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in gene
Externí odkaz:
https://doaj.org/article/c6d13eb198294ceebba143d7e3429f0c
Publikováno v:
Equality, Diversity and Inclusion: An International Journal. 38:131-139
Purpose Supporting the advancement of science, technology, engineering and mathematics (STEM) in ways that help to ensure the health, prosperity, welfare and security of the nation has been central to the mission of the US National Science Foundation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aadf1d0c0051f95bfa2c81f8d674cacd
https://doi.org/10.1108/edi-09-2017-0188
https://doi.org/10.1108/edi-09-2017-0188
Autor:
Steven Orr, Sudhir Raghavan, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee, Christina George, Yiqiang Wang, Shermaine Mitchell-Ryan
Publikováno v:
Journal of Medicinal Chemistry. 58:1479-1493
A new series of 5-substituted thiopheneyl pyrrolo[2,3-d]pyrimidines 6–11 with varying chain lengths (n = 1–6) were designed and synthesized as hybrids of the clinically used anticancer drug pemetrexed (PMX) and our 6-substituted thiopheneyl pyrro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a9b2fbe41829393229ddf5bb1fb928
https://doi.org/10.1021/jm501787c
https://doi.org/10.1021/jm501787c
Autor:
Aleem Gangjee, Manasa P. Ravindra, Shermaine Mitchell-Ryan, Larry H. Matherly, Steven Orr, Eric C. Hales, Sudhir Raghavan, Christina Cherian, Zhanjun Hou, Yiqiang Wang
Publikováno v:
Journal of Medicinal Chemistry. 56:10016-10032
We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04814daf7076b8793492dfa4f0b9b0fe
https://doi.org/10.1021/jm401328u
https://doi.org/10.1021/jm401328u
Autor:
Mike R. Wilson, Siobhan M. Deis, Kathryn White, Shermaine Mitchell-Ryan, Larry H. Matherly, Lei Wang, Aleem Gangjee, Christina George, Carrie O'Connor, Steven Orr, Charles E. Dann, Adrianne Wallace, Si Yang, Sudhir Raghavan, Lisa Polin, Juiwanna Kushner, Zhanjun Hou
Publikováno v:
Journal of medicinal chemistry. 58(17)
2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) and AGF154 (7)] were synthesized as potential antitumor agents. These analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ced0f2d44a66b7e98444f183ba4fdbc
https://pubmed.ncbi.nlm.nih.gov/26317331
https://pubmed.ncbi.nlm.nih.gov/26317331
Autor:
Larry H. Matherly, Min Hwang Chang, Shermaine Mitchell-Ryan, Zhanjun Hou, Andreas Fulterer, Juiwanna Kushner, Mark Stout, Lei Wang, Aleem Gangjee, Sita Kugel Desmoulin, Michael F. Romero, Kathryn White, Lisa Polin, Christina Cherian
Publikováno v:
Journal of medicinal chemistry. 54(20)
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine antifolates with a thienoyl side chain (compounds 1-3, respectively) were synthesized for comparison with compound 4, the previous lead compound of this series. Conversion of hydroxyl acetylen-thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e886d93fc91d38622206770ce0f1c80
https://pubmed.ncbi.nlm.nih.gov/21879757
https://pubmed.ncbi.nlm.nih.gov/21879757
Autor:
Adrianne Wallace, Shermaine Mitchell-Ryan, Aleem Gangjee, Steven Orr, Larry H. Matherly, Lalit K. Golani, Lisa Polin, Christina Cherian
Publikováno v:
Cancer Research. 74:1620-1620
Reduced folates are essential cofactors for biosynthesis of purines and pyrimidines. Since humans do not synthesize folate, it is necessary to obtain these cofactors from dietary sources. In mammals, three specialized systems exist that mediate membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e3b636dc083026362dbcb7e1b0ce93
https://doi.org/10.1158/1538-7445.am2014-1620
https://doi.org/10.1158/1538-7445.am2014-1620
Autor:
Larry H. Matherly, Shermaine Mitchell-Ryan, Christina Cherian, Yiqiang Wang, Steven Orr, Zhanjun Hou, Aleem Gangjee
Publikováno v:
Cancer Research. 73:5493-5493
Interest has focused on folate receptor (FR) α for delivering cytotoxic folate-based therapeutics to solid tumors, as FRα is highly expressed in certain tumors, including ovarian and non-small cell lung cancers. While FRα is present in normal epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad7ba87d34104af47fd0122eade7df0f
https://doi.org/10.1158/1538-7445.am2013-5493
https://doi.org/10.1158/1538-7445.am2013-5493
Autor:
Erika Etnyre, Aleem Gangjee, Shermaine Mitchell-Ryan, Christina Cherian, Zhanjun Hou, Yiqiang Wang, Larry H. Matherly
Publikováno v:
Cancer Research. 72:3822-3822
Clinically used antifolates are transported into cells by three major systems including the reduced folate carrier (RFC), folate receptor (FR)α, and proton-coupled folate transporter (PCFT). RFC is ubiquitiously expressed in normal tissues, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::415b107e1f4e5a713b71c73b9e1b756b
https://doi.org/10.1158/1538-7445.am2012-3822
https://doi.org/10.1158/1538-7445.am2012-3822