Výsledky vyhledávání - "Sherine E, Thomas"

Akademický článek

RNA structure mediated thermoregulation: What can we learn from plants?

Autor: Sherine E. Thomas, Martin Balcerowicz, Betty Y.-W. Chung

Publikováno v: Frontiers in Plant Science, Vol 13 (2022)

RNA molecules have the capacity to form a multitude of distinct secondary and tertiary structures, but only the most energetically favorable conformations are adopted at any given time. Formation of such structures strongly depends on the environment

Externí odkaz: https://doaj.org/article/d62157500c494935ad1d29fc385c46b8

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Akademický článek

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

Autor: Sherine E. Thomas, William J. McCarthy, Jamal El Bakali, Karen P. Brown, So Yeon Kim, Michal Blaszczyk, Vítor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for mycobacterial infections lik

Externí odkaz: https://doaj.org/article/2ec45fe855c2444086e1ec68c5424f59

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Akademický článek

A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

Autor: Pooja Gupta, Sherine E. Thomas, Shaymaa A. Zaidan, Maria A. Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G. Coyne, William R. Jacobs, Jr., Tom L. Blundell, Sangeeta Tiwari, Vítor Mendes

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3491-3506 (2021)

The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in mice, while inhibition o

Externí odkaz: https://doaj.org/article/0589d4fe9fbe444192900ca3afd6da59

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Akademický článek

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Autor: Christopher A. Beaudoin, Arian R. Jamasb, Ali F. Alsulami, Liviu Copoiu, Andries J. van Tonder, Sharif Hala, Bridget P. Bannerman, Sherine E. Thomas, Sundeep Chaitanya Vedithi, Pedro H.M. Torres, Tom L. Blundell

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3938-3953 (2021)

Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs,

Externí odkaz: https://doaj.org/article/fc38282fc8cf4a6ebe271959bab2bffd

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Akademický článek

Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery

Autor: Vaishali P. Waman, Sundeep Chaitanya Vedithi, Sherine E. Thomas, Bridget P. Bannerman, Asma Munir, Marcin J. Skwark, Sony Malhotra, Tom L. Blundell

Publikováno v: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 109-118 (2019)

ABSTRACTOf the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium tuberculosis (causati

Externí odkaz: https://doaj.org/article/9116d916e1344fa5bd606e3ae084c714

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Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Autor: Sitthivut Charoensutthivarakul, Sherine E. Thomas, Amy Curran, Karen P. Brown, Juan M. Belardinelli, Andrew J. Whitehouse, Marta Acebrón-García-de-Eulate, Jaspar Sangan, Subramanian G. Gramani, Mary Jackson, Vitor Mendes, R. Andres Floto, Tom L. Blundell, Anthony G. Coyne, Chris Abell

Publikováno v: ACS Infectious Diseases. 8:296-309

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a26c6af4b6de128bd9f1582c73b377
https://doi.org/10.1021/acsinfecdis.1c00432

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Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Autor: Pedro H M Torres, Sharif Hala, Liviu Copoiu, Christopher A. Beaudoin, Tom L. Blundell, Ali F. Alsulami, Arian R. Jamasb, Andries J. van Tonder, Sherine E. Thomas, Bridget P. Bannerman, Sundeep Chaitanya Vedithi

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3938-3953 (2021)

SummaryViruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff7e4bdc87d686aaf05734ef6a413f8
http://www.sciencedirect.com/science/article/pii/S2001037021002798

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A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

Autor: William R. Jacobs, Maria A. Pasillas, Ailidh Burgess, Tom L. Blundell, Sangeeta Tiwari, Anthony G. Coyne, James Cory-Wright, Vitor Mendes, Clio Meghir, Víctor Sebastián-Pérez, Sherine E. Thomas, Shaymaa A. Zaidan, Emma Cattermole, Pooja Gupta, Chris Abell

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3491-3506 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Computational and Structural Biotechnology Journal
'Computational and Structural Biotechnology Journal ', vol: 19, pages: 3491-3506 (2021)

16 p.-8 fig.-4 tab.
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862c280712d00acb38047d21232c7e0d
http://www.sciencedirect.com/science/article/pii/S2001037021002373

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Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Autor: Sophie Burbaud, Andrew J. Whitehouse, Ramanuj Lahiri, Jasper Sangen, Sherine E. Thomas, Tom L. Blundell, Pooja Gupta, Helena I. Boshoff, Juan Manuel Belardinelli, Mary Jackson, Sony Malhotra, R. Andres Floto, Karen Brown, M. Daben J. Libardo, Anthony G. Coyne, Vitor Mendes, Chris Abell

Publikováno v: Nucleic Acids Research

Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0499f42b3a6c17233ceb9dfce7e5197
https://doi.org/10.1093/nar/gkaa539

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Structural Characterization of

Autor: Sherine E, Thomas, William J, McCarthy, Jamal, El Bakali, Karen P, Brown, So Yeon, Kim, Michal, Blaszczyk, Vítor, Mendes, Chris, Abell, R Andres, Floto, Anthony G, Coyne, Tom L, Blundell

Publikováno v: Frontiers in molecular biosciences. 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f830e937bd64d4f28bccd5157510669c
https://pubmed.ncbi.nlm.nih.gov/35712348

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