Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sherin M. Elfeky"'
Autor:
Samar El-Kalyoubi, Samiha A. El-Sebaey, Ahmed A. El-Sayed, Moustafa S. Abdelhamid, Fatimah Agili, Sherin M. Elfeky
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Nanotechnology-based strategies can overcome the limitations of conventional cancer therapies. Hence, novel series of pyrimidine Schiff bases (4–9) were employed in the synthesis of selenium nanoparticle forms (4NPs–9NPs). All selenium nano-sized
Externí odkaz:
https://doaj.org/article/32c079577e1b4789b7295108551e843f
Autor:
Samar El-Kalyoubi, Samiha A. El-Sebaey, A. M. Rashad, Hanan A. AL-Ghulikah, Mostafa M. Ghorab, Sherin M. Elfeky
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a–f and oxo-selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibite
Externí odkaz:
https://doaj.org/article/1df0066a07f24a0586d556a33458cb72
Autor:
Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1303 (2023)
Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as
Externí odkaz:
https://doaj.org/article/a84624ebb1be4e469cd8a8848b2ea4a3
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 503 (2023)
The increasing incidence of erythromycin and erythromycin-induced resistance to clindamycin among Staphylococcus aureus (S. aureus) is a serious problem. Patients infected with inducible resistance phenotypes may fail to respond to clindamycin. This
Externí odkaz:
https://doaj.org/article/5b5be448af04426d86d25aadf8169ace
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 2, Pp 103614- (2022)
Through a two-step procedure, 3-amino-7-chloro-2-methylquinazolin-4(3H)-one was synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with chloro acetylchloride, then nucleophilically substituted with various second
Externí odkaz:
https://doaj.org/article/8d756dfdfc524ef5bef91a45de69f054
Publikováno v:
Journal of Chemistry, Vol 2019 (2019)
Novel 6(3-1H-1,2,4-triazol-1-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (7a–e) were synthesized from different enaminones (6a–e) with 6-hydrazinyl-3-phenylquinazoline-2,4(1H,3H)-dione. 2,6(4-2-Substituted-1,3,5-triazin-1(2H)-yl)-3-phenylquinazolin
Externí odkaz:
https://doaj.org/article/604fdc29b2c74fdb9150947af67a93fb
Publikováno v:
Bioorganic chemistry. 124
Substituted aldehydes, ethyl 2-(2-amino-thiazol-4-yl)acetate), and 2-mercaptoacetic acid, in a three-component one-pot green synthetic approach afforded 2-arylthiazolidin-4-one- thiazole hybrids(T1-T13). Compounds showed good anti-tubercular activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1eb3b92b1c46c4c0e2cc3a050e036a
https://pubmed.ncbi.nlm.nih.gov/35447406
https://pubmed.ncbi.nlm.nih.gov/35447406
Publikováno v:
Archiv der PharmazieREFERENCES. 353(1)
N-Substituted isatoic anhydrides were used as starting materials for the synthesis of compounds 5-16 through alkali hydrolysis, Schiff base reactions, and oxidation. Compounds 18-23 were obtained by thionation of their oxo isosteres using Lawesson's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741081f2a6c73b4f93f741eb858288a7
https://pubmed.ncbi.nlm.nih.gov/31696968
https://pubmed.ncbi.nlm.nih.gov/31696968
Publikováno v:
Egyptian Journal of Chemistry.
Phosphodiesterase 7A enzyme is one the most recent targets for designing potent anti-inflammatory agents with minimal side effects. Quinazolinones are unique building blocks of wide biological activities. Different Quinazolinones were reported to act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8766054b9d36dcb7cfa46b6bc6a6de8c
https://doi.org/10.21608/ejchem.2019.7130.1587
https://doi.org/10.21608/ejchem.2019.7130.1587
Publikováno v:
Journal of Chemistry, Vol 2019 (2019)
Novel 6(3-1H-1,2,4-triazol-1-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (7a–e) were synthesized from different enaminones (6a–e) with 6-hydrazinyl-3-phenylquinazoline-2,4(1H,3H)-dione. 2,6(4-2-Substituted-1,3,5-triazin-1(2H)-yl)-3-phenylquinazolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8cc8fd2e0067274bbfc0d8c96509a8