Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sherilyn Adcock"'
Publikováno v:
Reviews on recent clinical trials. 16(3)
Background: Phase 1 studies comprise the first exposure of a promising new chemical entity in healthy volunteers or, when appropriate, in patients. To assure a solid foundation for subsequent drug development, this first step must carefully assess th
Publikováno v:
Clinical Therapeutics. 39:1695-1705
Purpose There is a strong association between attention-deficit/hyperactivity disorder (ADHD) and alcohol abuse, yet no studies have systematically assessed the effect of alcohol on the pharmacokinetics of psychostimulants such as amphetamine (AMP) i
Autor:
Barry J. Gertz, Kala-Jyoti Viswanathan-Aiyer, Arturo G. Porras, Jules I. Schwartz, Saurabh Mukhopadhyay, Sherilyn Adcock, David L. Ebel
Publikováno v:
Journal of clinical pharmacology. 43(2)
Patients receiving nonsteroidal anti-inflammatory drug therapy may also require administration of corticosteroids, particularly patients with rheumatoid arthritis. To investigate the effect of rofecoxib on the single-dose pharmacokinetics of oral pre
Autor:
David Dobratz, Michael H. Davidson, Terry M. Jones, Barry J. Gertz, Jerris Hedges, Sherilyn Adcock, Robert A. Cohen, Saurabh Mukhopadhyay, Carl Moritz, Kenneth Grasing, Jules I. Schwartz, Kenneth Bachmann, Kathleen J. McBride, Chi‐Chung Chan
Publikováno v:
Clinical pharmacology and therapeutics. 65(6)
Cyclooxygenase (COX) exists as constitutive (COX-1) and inducible (COX-2) isoforms. Nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and diclofenac inhibit both COX-1 and COX-2. The role of COX-2 in the genesis of fever in monkeys and h