Genetic and Epigenetic Regulation of MEFV Gene and Their Impact on Clinical Outcome in Auto-Inflammatory Familial Mediterranean Fever Patients

Autor: May E. Zekry, Al-Aliaa M. Sallam, Sherihan G. AbdelHamid, Waheba A. Zarouk, Hala T. El-Bassyouni, Hala O. El-Mesallamy

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 721-737 (2023)

Epigenetic modifications play a pivotal role in autoimmune/inflammatory disorders and could establish a bridge between personalized medicine and disease epidemiological contexts. We sought to investigate the role of epigenetic modifications beside ge

Externí odkaz: https://doaj.org/article/f7c85130ea974a83b75d2dbe8c853fd6

Bone Marrow Mesenchymal Stem Cells and Their Derived Extracellular Vesicles Attenuate Non-Alcoholic Steatohepatitis-Induced Cardiotoxicity via Modulating Cardiac Mechanisms

Autor: Marwa O. El-Derany, Sherihan G. AbdelHamid

Publikováno v: Life, Vol 12, Iss 3, p 355 (2022)

Cardiovascular-disease (CVD)-related mortality has been fueled by the upsurge of non-alcoholic steatohepatitis (NASH). Mesenchymal stem cells (MSCs) were extensively studied for their reparative power in ameliorating different CVDs via direct and par

Externí odkaz: https://doaj.org/article/99c7f6343cdb4b3bb6f9e001cf0112ab

Deciphering epigenetic(s) role in modulating susceptibility to and severity of COVID-19 infection and/or outcome: a systematic rapid review

Autor: Aya A Refaat, Nadia M. Hamdy, Sherihan G. AbdelHamid, Lougine A Elgendy, Laila A Elmawardy, Nourhan Sherif, Mark M Manolly, Anthony M Benjamin, Nada Abd Elmaksoud

Publikováno v: Environmental Science and Pollution Research International

Graphical abstract COVID-19 pandemic waves hitting worldwide result in drastic postinfection complications with interindividual variations, which raised the question for the cause of these observed variations. This urged to think “the impact of env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f47e5b1fa51c00f04bdf024a3be80b8
http://europepmc.org/articles/PMC8359636

Amelioration of Diabetic Nephropathy by Targeting Autophagy via Rapamycin or Fasting: Relation to Cell Apoptosis/Survival

Autor: Nesreen Moustafa Omar, Sherihan G. AbdelHamid, Ahmed M. Mansour, Hala O. El-Mesallamy, Khaled Gouda

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 120, Pp 1698-1714 (2021)
Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 120-1714

Autophagy has been demonstrated to have a beneficial effect on diabetic nephropathy (DN). Rapamycin, an inhibitor of mTOR, was shown to stimulate β-cell autophagy. However, its effects on preventing or ameliorating DN is unclear, and its effects are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ed675fbc9e397770e2a7abae92796a
https://pubmed.ncbi.nlm.nih.gov/34698133

BRCA1 and BRCA2 truncating mutations and variants of unknown significance in Egyptian female breast cancer patients

Autor: Hany Abdel-Aziz, Hala O. El-Mesallamy, Sherihan G. AbdelHamid, Abdel-Rahman N. Zekri

Publikováno v: Clinica chimica acta; international journal of clinical chemistry. 512

Background Breast cancer is the most common malignancy among women worldwide and the leading cause of cancer death in economically developing countries. We sought to study the contribution of BRCA1/2 mutations to the burden of breast cancer in Egypt.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5d949a1d5e3dbe8cde9121707d253a
https://pubmed.ncbi.nlm.nih.gov/33278427