Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sherihan El-Sayed"'
Autor:
Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, Paul R. Kasher
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108968- (2024)
Summary: Excessive or aberrant NLRP3 inflammasome activation has been implicated in the progression and initiation of many inflammatory conditions; however, currently no NLRP3 inflammasome inhibitors have been approved for therapeutic use in the clin
Externí odkaz:
https://doaj.org/article/0f496b494bea49a4bf551e605784fa33
Publikováno v:
Molecules, Vol 27, Iss 19, p 6213 (2022)
The NLRP3 inflammasome is currently an exciting target for drug discovery due to its role in various inflammatory diseases; however, to date, no NLRP3 inhibitors have reached the clinic. Several studies have used natural products as hit compounds to
Externí odkaz:
https://doaj.org/article/afdc3102f7274f47bef0fa62f7117612
Autor:
Sherihan El-Sayed, Kamel Metwally, Abdalla A. El-Shanawani, Lobna M. Abdel-Aziz, Harris Pratsinis, Dimitris Kletsas
Publikováno v:
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017)
Abstract Background Rhodanines and quinazolinones have been reported to possess various pharmacological activities. Results A novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensation between 4-[3-(substitute
Externí odkaz:
https://doaj.org/article/23dd310869994a9a86296d339b2d7c4b
Autor:
Mai A. Elhemely, Asma A. Belgath, Sherihan El-Sayed, Kepa K. Burusco, Manikandan Kadirvel, Annalisa Tirella, Katherine Finegan, Richard A. Bryce, Ian J. Stratford, Sally Freeman
Publikováno v:
Journal of Medicinal Chemistry. 65:4783-4797
Publikováno v:
El Sayed, S, Freeman, S & Bryce, R A 2022, ' Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation ', Protein science, vol. 31, no. 10 . https://doi.org/10.1002/pro.4420
The NLRP3 inflammasome is a cytoplasmic complex that regulates the activa- tion of inflammatory cytokines and, given its implication in a range of dis- eases, is an important therapeutic target. The cofactor ATP and the centrosomal kinase NEK7 are im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27b13e3fb77ed7017279bc50e52f33d
https://www.research.manchester.ac.uk/portal/en/publications/probing-the-effect-of-nek7-and-cofactor-interactions-on-dynamics-of-nlrp3-monomer-using-molecular-simulation(f6a624d0-8f09-4642-8fc4-855394195e36).html
https://www.research.manchester.ac.uk/portal/en/publications/probing-the-effect-of-nek7-and-cofactor-interactions-on-dynamics-of-nlrp3-monomer-using-molecular-simulation(f6a624d0-8f09-4642-8fc4-855394195e36).html
Autor:
Lobna M. Abdel-Aziz, Sherihan El-sayed, Dimitris Kletsas, Harris Pratsinis, Kamel Metwally, Abdalla El-Shanawani
Publikováno v:
Chemistry Central Journal
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017)
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017)
Background Rhodanines and quinazolinones have been reported to possess various pharmacological activities. Results A novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensation between 4-[3-(substitutedphenyl)-
Autor:
Lobna M. Abdel-Aziz, Ahmed A. Elrashedy, Kamel Metwally, Mahmoud E. S. Soliman, Sherihan El-sayed, Vito Coviello, Abdalla El-Shanawani, Concettina La Motta, Luca Quattrini
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(20)
A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e exhibited