Výsledky vyhledávání - "Sherif K. Girees"

Abstract 899: Combination of PI3K and MEK inhibitor chemosensitivity in human tumor explants and cell lines using the Mosaic Blue assay and relationship to biomarkers by immunohistochemistry

Autor: Gela C. Sia, Christopher A. Kerfoot, Jianping Zheng, Eric Olsen, Ryan S. Lim, Sherif K. Girees, Patricia A. Cash, Lisa M. Dauffenbach

Publikováno v: Cancer Research. 74:899-899

The PI3K and MEK pathways promote tumor cell survival through a variety of downstream signals and are commonly explored in cancer research. Many agents are in clinical development and new evidence suggests that a combination of these inhibitors may b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90b50a9797371b71fb80673e3c30633a
https://doi.org/10.1158/1538-7445.am2014-899

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Abstract 3745: Optimization of an assay for the detection of phosphorylated FAK by immunohistochemistry in formalin-fixed, paraffin-embedded human tissue and cell lines

Autor: Gela C. Sia, Christopher A. Kerfoot, Jianping Zheng, Sherif K. Girees, Ryan S. Lim, Lisa M. Dauffenbach, Patricia A. Cash, Rana Richeh, Eric Olsen

Publikováno v: Cancer Research. 74:3745-3745

Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase with elevated expression in most human cancers, most notably in invasive metastasis. FAK is involved in cell adhesion, motility, and apoptosis, and it is a target for oncology ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f23dbd8319499b3f88ca878da57f962e
https://doi.org/10.1158/1538-7445.am2014-3745

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Abstract A35: Evaluation of MEK inhibitor chemosensitivity in human tumor explants using the Mosaic Blue Assay and relationship to biomarkers by immunohistochemistry

Autor: Gela C. Sia, Christopher A. Kerfoot, Sherif K. Girees, Eric Olsen, Lisa M. Dauffenbach, Patricia A. Cash, Ryan S. Lim, Jianping Zheng

Publikováno v: Molecular Cancer Therapeutics. 12:A35-A35

The MEK pathway is activated in most cancers. Several chemotherapeutic agents target this pathway through inhibition of MEK, ERK or upstream receptor tyrosine kinases and are in clinical trials to treat patients with solid tumors. The use of chemosen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38df83987b2fcbaf17c35bac6d60ee52
https://doi.org/10.1158/1535-7163.targ-13-a35

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Abstract 3510: Evaluation of PI3K Inhibitor chemosensitivity in human tumor explants using the Mosaic Blue assay and relationship to biomarkers by immunohistochemistry

Autor: Ryan S. Lim, Gela C. Sia, Sherif K. Girees, Eric Olsen, Jianping Zheng, Christopher A. Kerfoot, Patricia A. Cash, Lisa M. Dauffenbach

Publikováno v: Cancer Research. 73:3510-3510

The AKT protein family plays an important role in cellular survival by inhibiting apoptotic processes and is one of the major downstream targets of the phosphatidylinositol 3-kinase (PI3K) pathway. Mammalian target of rapamycin (mTOR) is a key kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3ba77e537a990ee3588b142f27cd901
https://doi.org/10.1158/1538-7445.am2013-3510

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Abstract 4959: Multispectral imaging of chromogenic multiplex IHC assays as an alternative to fluorescent methods

Autor: Lisa M. Dauffenbach, Sherif K. Girees, Christopher A. Kerfoot

Publikováno v: Cancer Research. 70:4959-4959

Detection and analysis of two or more co-localized antigens by light microscopy has been hindered by the difficulty in discerning and quantifying overlaying chromogens. Performing multi-analyte immunohistochemistry has many potential benefits and app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2354f79e50d5ba5ad9d805f967950ce
https://doi.org/10.1158/1538-7445.am10-4959

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