Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Sherif F. El‐Khamisy"'
Autor:
Francis M. Barnieh, Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer, Sherif F. El‐Khamisy
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Targeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical
Externí odkaz:
https://doaj.org/article/89b2cd1dff6344aabd813f0ac8032b72
Autor:
Walaa Ramadan Allam, Mohamed Tharwat Hegazy, Mohamed A. Hussein, Naguib Zoheir, Luca Quartuccio, Sherif F. El-Khamisy, Gaafar Ragab
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The treatment of HCV and its sequelae are used to be predominantly based on Interferon (IFN). However, this was associated with significant adverse events as a result of its immunostimulant capabilities. Since their introduction, the directl
Externí odkaz:
https://doaj.org/article/21be55ec40a74412bb0b72bdc09439ca
Autor:
Zina Alaswad, Nayera E. Attallah, Basma Aboalazm, Eman S. Elmeslhy, Asmaa S. Mekawy, Fatma A. Afify, Hesham K. Mahrous, Ashrakat Abdalla, Mai A. Rahmoon, Ahmed A. Mohamed, Ahmed H. Shata, Rana H. Mansour, Fareed Aboul-ela, Mohamed Elhadidy, Biola M. Javierre, Sherif F. El-Khamisy, Menattallah Elserafy
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 22, Iss 4, Pp 100427- (2024)
The utilization of human cDNA libraries in yeast genetic screens is an approach that has been used to identify novel gene functions and/or genetic and physical interaction partners through forward genetics using yeast two-hybrid (Y2H) and classical c
Externí odkaz:
https://doaj.org/article/85075acebc0142d48692eeb42ddb7a45
Autor:
Louise K. Stevenson, Amy J. Page, Matthew Dowson, Sameh K. ElBadry, Francis M. Barnieh, Robert A. Falconer, Sherif F. El-Khamisy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Classically, ATM is known for its role in sensing double-strand DNA breaks, and subsequently signaling for their repair. Non-canonical roles of ATM include transcriptional silencing, ferroptosis, autophagy and angiogenesis. Angiogenesis mediated by A
Externí odkaz:
https://doaj.org/article/d4199569099e4c3e975aa4fb68e4854c
Autor:
Francis M. Barnieh, Sebastian P. Galuska, Paul M. Loadman, Simon Ward, Robert A. Falconer, Sherif F. El-Khamisy
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108219- (2023)
Summary: Harnessing the differences between cancer and non-cancer tissues presents new opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated protein, is one example with significant unmet clinical potential in cance
Externí odkaz:
https://doaj.org/article/bd2bf1908dae46818c9cada538aeea92
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1
Externí odkaz:
https://doaj.org/article/eb0bfd4248dd4385a038034986f146a7
Autor:
Ashraf A. Elghzaly, Celi Sun, Loren L. Looger, Misa Hirose, Mohamed Salama, Noha M. Khalil, Mervat Essam Behiry, Mohamed Tharwat Hegazy, Mohamed Ahmed Hussein, Mohamad Nabil Salem, Ehab Eltoraby, Ziyad Tawhid, Mona Alwasefy, Walaa Allam, Iman El-Shiekh, Menattallah Elserafy, Anwar Abdelnaser, Sara Hashish, Nourhan Shebl, Abeer Abdelmonem Shahba, Amira Elgirby, Amina Hassab, Khalida Refay, Hanan Mohamed El-Touchy, Ali Youssef, Fatma Shabacy, Abdelkader Ahmed Hashim, Asmaa Abdelzaher, Emad Alshebini, Dalia Fayez, Samah A. El-Bakry, Mona H. Elzohri, Eman Nagiub Abdelsalam, Sherif F. El-Khamisy, Saleh Ibrahim, Gaafar Ragab, Swapan K. Nath
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian anc
Externí odkaz:
https://doaj.org/article/e91f1e8627274d5b8178395686929526
Autor:
Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.
Externí odkaz:
https://doaj.org/article/53d171bea0d243d0a270df932d095042
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/dfc92a72b0e84b5eb72a2e299ffe4625
Autor:
Mohamed K. Hassan, Amr A. Waly, Waheba Elsayed, Sarah Keshk, Walaa Ramadan Allam, Sherif F. El-khamisy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Taxane is a family of front-line chemotherapeutic agents against ovarian cancer (OC). The therapeutic efficacy is frequently counteracted by the development of chemoresistance, leading to high rates of relapse in OC patients. The role(s) of
Externí odkaz:
https://doaj.org/article/4e3629cb503e4e85af2738dd807c0589