Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sherif E. Gabriel"'
Autor:
John P Clancy, Rhonda D Szczesniak, Melissa A Ashlock, Sarah E Ernst, Lijuan Fan, Douglas B Hornick, Philip H Karp, Umer Khan, James Lymp, Alicia J Ostmann, Amir Rezayat, Timothy D Starner, Shajan P Sugandha, Hongtao Sun, Nancy Quinney, Scott H Donaldson, Steven M Rowe, Sherif E Gabriel
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73905 (2013)
Intestinal current measurements (ICM) from rectal biopsies are a sensitive means to detect cystic fibrosis transmembrane conductance regulator (CFTR) function, but have not been optimized for multicenter use. We piloted multicenter standard operating
Externí odkaz:
https://doaj.org/article/a825b39f5ba248d7855a452f650e4730
Autor:
Liqun Zhang, Brian Button, Sherif E Gabriel, Susan Burkett, Yu Yan, Mario H Skiadopoulos, Yan Li Dang, Leatrice N Vogel, Tristan McKay, April Mengos, Richard C Boucher, Peter L Collins, Raymond J Pickles
Publikováno v:
PLoS Biology, Vol 7, Iss 7, p e1000155 (2009)
Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus dehydration, decreased mucus transport, and mucus plugging of the airways
Externí odkaz:
https://doaj.org/article/fc5afb662e8a47058a01b45dac27ddf5
Autor:
Michel Bagnat, Sara Herbstreith, Jan Huisken, Silvia Curado, Sherif E. Gabriel, Keith E. Mostov, Didier Y.R. Stainier, Adam Navis, Koroboshka Brand-Arzamendi
Publikováno v:
Current Biology. 20(20):1840-1845
Summary Transport of chloride through the cystic fibrosis transmembrane conductance regulator (CFTR) channel is a key step in regulating fluid secretion in vertebrates [1, 2]. Loss of CFTR function leads to cystic fibrosis [1, 3, 4], a disease that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee04dc35a99b305f18df2de51fc300aa
Autor:
C. William Davis, Seiko F. Okada, Catharina van Heusden, Silvia M. Kreda, Lubna H. Abdullah, Sherif E. Gabriel, Richard C. Boucher, Wanda K. O'Neal, Eduardo R. Lazarowski
Publikováno v:
The Journal of Physiology. 584:245-259
The efficiency of the mucociliary clearance (MCC) process that removes noxious materials from airway surfaces depends on the balance between mucin secretion, airway surface liquid (ASL) volume, and ciliary beating. Effective mucin dispersion into ASL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2706325b3f68cf213122734a1ad8080b
https://doi.org/10.1113/jphysiol.2007.139840
https://doi.org/10.1113/jphysiol.2007.139840
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 287:G33-G41
The effects of CLCA protein expression on the regulation of Cl− conductance by intracellular Ca2+ and cAMP have been studied previously in nonepithelial cell lines chosen for low backgrounds of endogenous Cl− conductance. However, CLCA proteins h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdd72d4a4ef70d016897d7f7b680104
https://doi.org/10.1152/ajpgi.00023.2004
https://doi.org/10.1152/ajpgi.00023.2004
Publikováno v:
Biochemical and Biophysical Research Communications. 298:531-536
Members of the CLCA protein family are expressed in airway and intestinal epithelium, where they may participate in secretory activity as mediators of chloride conductance. A calcium-dependent chloride conductance has been observed upon expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f1cff0846a59cfe6431b9f8813fb7
https://doi.org/10.1016/s0006-291x(02)02498-1
https://doi.org/10.1016/s0006-291x(02)02498-1
Expression of nucleotide-regulated Cl−currents in CF and normal mouse tracheal epithelial cell lines
Publikováno v:
American Journal of Physiology-Cell Physiology. 279:C1578-C1586
The dominant route for Cl−secretion in mouse tracheal epithelium is via Cl−channels different from the cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the channel that is defective in CF. It has been proposed that the use of puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ab63384b724dc4dd7f526baa7bfdd7
https://doi.org/10.1152/ajpcell.2000.279.5.c1578
https://doi.org/10.1152/ajpcell.2000.279.5.c1578
Publikováno v:
Transplantation. 69:399-405
BACKGROUND Obliterative bronchiolitis (OB), chronic allograft rejection of the lung, is a major cause of morbidity and mortality after lung transplantation. Previous studies using the heterotopic mouse trachea model of chronic airway rejection have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ab23cd59b3c01402cf085937d518e2
https://doi.org/10.1097/00007890-200002150-00016
https://doi.org/10.1097/00007890-200002150-00016
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 276:G58-G63
We have identified an agent (SP-303) that shows efficacy against in vivo cholera toxin-induced fluid secretion and in vitro cAMP-mediated Cl−secretion. Administration of cholera toxin to adult mice results in an increase in fluid accumulation (FA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4995302565d7ee6d4f53adf3d4f0b0
https://doi.org/10.1152/ajpgi.1999.276.1.g58
https://doi.org/10.1152/ajpgi.1999.276.1.g58
Autor:
Barbara R. Grubb, Sherif E. Gabriel
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 273:G258-G266
Cystic fibrosis (CF) is a fatal genetic disorder that affects approximately 1 in 2,500 live Caucasian births. The disease can be described as a generalized exocrine disease affecting a variety of epithelial tissues, with early manifestation as meconi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df709daacd459cba74ade23334773d9a
https://doi.org/10.1152/ajpgi.1997.273.2.g258
https://doi.org/10.1152/ajpgi.1997.273.2.g258