Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis

Autor: Joanna M. Bilak, Jian L. Yeo, Gaurav S. Gulsin, Anna-Marie Marsh, Manjit Sian, Abhishek Dattani, Sarah L. Ayton, Kelly S. Parke, Moira Bain, Wenjie Pang, Sherif Boulos, Tim G. St Pierre, Melanie J. Davies, Thomas Yates, Gerry P. McCann, Emer M. Brady

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 10, Iss 5, p 191 (2023)

Type 2 diabetes (T2D) confers a high risk of heart failure frequently with evidence of cardiovascular structural and functional abnormalities before symptom onset. The effects of remission of T2D on cardiovascular structure and function are unknown.

Externí odkaz: https://doaj.org/article/12f9b47f3553467e9d88c500f03d0b87

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Autor: Sherif Boulos, Bruno P. Meloni, Peter G. Arthur, Bernadette Majda, Christina Bojarski, Neville W. Knuckey

Publikováno v: Neurobiology of Disease, Vol 25, Iss 1, Pp 54-64 (2007)

We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat

Externí odkaz: https://doaj.org/article/31f1aab8afdd49ae927354f8e9497508

Lack of Evidence for Decreased Protein Stability in the 2397 (Met) Haplotype of the Leucine Rich Repeat Kinase 2 Protein Implicated in Parkinson’s Disease

Autor: Wayne K. Greene, Rhiannon Morris, Frank L. Mastaglia, Sherif Boulos, Ryan S. Anderton, Lauren Hill

Publikováno v: Advances in Parkinson's Disease. :113-123

Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s disease. We previously reported that two mutations within the ROC domain, namely R1441C and A1442P, exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba101e10ff44cfeea64809052cedcdf1
https://doi.org/10.4236/apd.2017.64012

Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease

Autor: Miriam B. Vos, Lara Dimick-Santos, Ruby Mehta, Stephanie O. Omokaro, Johannes Taminiau, Elmer Schabel, David E. Kleiner, Peter Szitanyi, Piotr Socha, Jeffrey B. Schwimmer, Stephanie Noviello, Debra G. Silberg, Richard Torstenson, Veronica Miller, Joel E. Lavine, Nathalie Adda, William Baldyga, Rajarshi Banerjee, Cynthia Behling, Sherif Boulos, Gary Burgess, Dania Calboli, Edgar Charles, Rose Christian, Claude Cohen-Bacrie, Doina Cosma-Roman, Claus-Peter Danzer, Ingrid Delaet, Mark Delegge, Nicholas DiProspero, Kathleen Donohue, Laurent Fischer, Emer Fitzpatrick, Michael Fried, David Hagerty, Paula Hale, Keri Hildick, Dean Hum, Khurram Jamil, Lijuan Jiang, Saul Karpen, Matt Kelly, Rohit Kohli, Kattayoun Kordy, Nancy Krieger, Joel Lavine, Lois Lee, Eric Lefebvre, Patricia Lopez, Erica Lyons, Laura Malahias, Sophie Megnien, Peter Mesenbrink, Pansy Minnick, Christine Murray, Tien Nghiem, Nikki Nicholson, Wenjie Pang, Lisa Percival, Dan Peres, Margaret Powell, Dragos Roman, Mark Root, Claire Sampson, Arun Sanyal, Kathleen Schwarz, Star Seyedkazemi, David Shapiro, Reshma Shringarpure, Debra Silberg, Edward Smith, Robert Squires, William Treem, Pamela Vig, Miriam Vos, Mason Yamashita, Michael Zemel

Publikováno v: Gastroenterology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b982e78cf5b668a605de3b462e0f3fec
https://pubmed.ncbi.nlm.nih.gov/31520612

Is Cholesterol and Amyloid-β Stress Induced CD147 Expression a Protective Response? Evidence that Extracellular Cyclophilin A Mediated Neuroprotection is Reliant on CD147

Autor: Joanne Chieng, Limbikani J. Kanyenda, Simon M. Laws, Bruno P. Meloni, G. Verdile, Francis Mastaglia, Ralph N. Martins, Ryan S. Anderton, Sherif Boulos

Publikováno v: Journal of Alzheimer's Disease. 39:545-556

The CD147 protein is a ubiquitous multifunctional membrane receptor. Expression of CD147, which is regulated by sterol carrier protein, reportedly modulates amyloid-β (Aβ), the neurotoxic peptide implicated in neuronal degeneration in Alzheimer's d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7bbf86062089e53364ccf36ecb695a
https://doi.org/10.3233/jad-131442