Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sherif Abdelhamed"'
Autor:
Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, Elizabeth A. Caine, Sherif Abdelhamed, Jeffrey J. Kooijman, Darcie J. Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M. Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J. Loughran, Ravi Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A. High, Junmin Peng, Shondra M. Pruett-Miller, Danette L. Daniels, Marjeta Urh, Anang A. Shelat, Charles G. Mullighan, Kristin M. Riching, Guido J. R. Zaman, Marcus Fischer, Jeffery M. Klco, Zoran Rankovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular glue degraders currently relies mostly on screening ap
Externí odkaz:
https://doaj.org/article/93a742dfa7284effac1e877a18d0d84e
Autor:
Juan M. Barajas, Masayuki Umeda, Lisett Contreras, Mahsa Khanlari, Tamara Westover, Michael P. Walsh, Emily Xiong, Chenchen Yang, Brittney Otero, Marc Arribas-Layton, Sherif Abdelhamed, Guangchun Song, Xiaotu Ma, Melvin E. Thomas 3rd, Jing Ma, Jeffery M. Klco
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Recent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor (UBTF). These alterations, which account for ~4.3% of AMLs in chil
Externí odkaz:
https://doaj.org/article/c0412839c08c4746996ccbccb8f2f704
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/0f9dd1beb0a54e77acb8df97016ee879
Autor:
Sherif Abdelhamed, Melvin E. Thomas III, Tamara Westover, Masayuki Umeda, Emily Xiong, Chandra Rolle, Michael P. Walsh, Huiyun Wu, Jason R. Schwartz, Virginia Valentine, Marcus Valentine, Stanley Pounds, Jing Ma, Laura J. Janke, Jeffery M. Klco
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired hematopoiesis, hypocellular marrows, and a greater risk of developing clonal chromosome 7 dele
Externí odkaz:
https://doaj.org/article/8e1fedf5f7604a43996d6f336e9bfb71
Publikováno v:
Haematologica, Vol 103, Iss 3 (2018)
Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopo
Externí odkaz:
https://doaj.org/article/b99ba54262f04008b15c5fbfaad093f4
Autor:
Zoran Rankovic, Gisele Nishiguchi, Sherif Abdelhamed, Sarah Young, Elizabeth Caine, Lauren Mascibroda, Jeffrey Kooijman, Sourav Das, Darcie Miller, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Ravi Kalathur, Junmin Peng, Shondra Pruett-Miller, Danette Daniels, Marjeta Urh, Anang Shelat, Charles Mullighan, Kristin Riching, Guido Zaman, Marcus Fischer, Jeffery Klco, Shilpa Narina, Allister Loughran, Anthony High
While the PROTAC approach to targeted protein degradation greatly benefits from rational design, the discovery of molecular glue degraders currently relies on screening strategies. Here, we describe screening of a library containing 3,630 cereblon bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f99fdfcf76b30197d41aed82ba9b1d
https://doi.org/10.21203/rs.3.rs-2883533/v1
https://doi.org/10.21203/rs.3.rs-2883533/v1
Autor:
Jeffery M. Klco, Xiaotu Ma, Soheil Meshinchi, Jeffrey E. Rubnitz, Jinghui Zhang, M. Madan Babu, Stanley Pounds, Charles G. Mullighan, James R. Downing, Todd A. Alonzo, Yi-Cheng Wang, Hiroto Inaba, Gang Wu, Michael Rusch, Delaram Rahbarinia, Evadnie Rampersaud, Jason R. Myers, Jonathan Miller, Ryan Hiltenbrand, Ilaria Iacobucci, Evan Parganas, Jenny L. Smith, Rhonda E. Ries, Yen-Chun Liu, Marcus B. Valentine, Virginia Valentine, Huiyun Wu, John Easton, Bengsheng Ju, Amanda R. Leonti, Andrew B. Kleist, Jamie L. Maciaszek, Scott G. Foy, Quang Tran, Pandurang Kolekar, Xiaolong Chen, Yanling Liu, Liqing Tian, Guangchun Song, Michael P. Walsh, Melvin E. Thomas, Juan M. Barajas, Sherif Abdelhamed, Tamara Westover, Kohei Hagiwara, Benjamin J. Huang, Jing Ma, Masayuki Umeda
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we present the spectrum of genomic alterations in 136 relapsed pediatric AMLs. We identified recurrent exon 13 tandem duplications (TD) in up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6c15e8269161afbfa878da7ad418de
https://doi.org/10.1158/2643-3230.c.6550658.v1
https://doi.org/10.1158/2643-3230.c.6550658.v1
Autor:
Richard W. Kriwacki, Charles G. Mullighan, Jeffery M. Klco, Cristina Mecucci, Danika Di Giacomo, Mylene C. Ferrolino, Priyanka Dogra, Swati Kinger, Carolyn Maslanka, Simranjot Bawa, Scott D. Gorman, Sherif Abdelhamed, Chunxu Qu, Qingsong Gao, Khaled Khairy, Anna Medyukhina, Stanley Pounds, Huiyun Wu, Cheon-Gil Park, Jingjing Chen, Michael R. White, Ilaria Iacobucci, Diana M. Mitrea, David W. Baggett, Brittany J. Pioso, Swarnendu Tripathi, Hazheen K. Shirnekhi, Nicole L. Michmerhuizen, Bappaditya Chandra
NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 that is prone to liquid–liquid phase separation (LLPS) in vitro. A predomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21291cf41a7ad1d4ff5a46d7e8fa0944
https://doi.org/10.1158/2159-8290.c.6549635
https://doi.org/10.1158/2159-8290.c.6549635
Autor:
Richard W. Kriwacki, Charles G. Mullighan, Jeffery M. Klco, Cristina Mecucci, Danika Di Giacomo, Mylene C. Ferrolino, Priyanka Dogra, Swati Kinger, Carolyn Maslanka, Simranjot Bawa, Scott D. Gorman, Sherif Abdelhamed, Chunxu Qu, Qingsong Gao, Khaled Khairy, Anna Medyukhina, Stanley Pounds, Huiyun Wu, Cheon-Gil Park, Jingjing Chen, Michael R. White, Ilaria Iacobucci, Diana M. Mitrea, David W. Baggett, Brittany J. Pioso, Swarnendu Tripathi, Hazheen K. Shirnekhi, Nicole L. Michmerhuizen, Bappaditya Chandra
Supplementary Table from Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cf278491ddafb5829f152b7789df1d
https://doi.org/10.1158/2159-8290.22541408
https://doi.org/10.1158/2159-8290.22541408
Autor:
Jeffery M. Klco, Xiaotu Ma, Soheil Meshinchi, Jeffrey E. Rubnitz, Jinghui Zhang, M. Madan Babu, Stanley Pounds, Charles G. Mullighan, James R. Downing, Todd A. Alonzo, Yi-Cheng Wang, Hiroto Inaba, Gang Wu, Michael Rusch, Delaram Rahbarinia, Evadnie Rampersaud, Jason R. Myers, Jonathan Miller, Ryan Hiltenbrand, Ilaria Iacobucci, Evan Parganas, Jenny L. Smith, Rhonda E. Ries, Yen-Chun Liu, Marcus B. Valentine, Virginia Valentine, Huiyun Wu, John Easton, Bengsheng Ju, Amanda R. Leonti, Andrew B. Kleist, Jamie L. Maciaszek, Scott G. Foy, Quang Tran, Pandurang Kolekar, Xiaolong Chen, Yanling Liu, Liqing Tian, Guangchun Song, Michael P. Walsh, Melvin E. Thomas, Juan M. Barajas, Sherif Abdelhamed, Tamara Westover, Kohei Hagiwara, Benjamin J. Huang, Jing Ma, Masayuki Umeda
Supplementary Data from Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61856b4d04dd5ad8020d0a10bd090d6c
https://doi.org/10.1158/2643-3230.22544486
https://doi.org/10.1158/2643-3230.22544486