Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sherif A. F. Rostom"'
Autor:
Diana K. Ghobrial, Nefertiti El-Nikhely, Eman Sheta, Hanan M. Ragab, Sherif A. F. Rostom, Hesham Saeed, Ahmed Wahid
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 637 (2023)
Liver Fibrosis can be life-threatening if left untreated as it may lead to serious, incurable complications. The common therapeutic approach is to reverse the fibrosis while the intervention is still applicable. Celecoxib was shown to exhibit some an
Externí odkaz:
https://doaj.org/article/2599163c563449319823adfd395d4604
Publikováno v:
Journal of Chemistry, Vol 2016 (2016)
The synthesis of polysubstituted pyridines, in addition to some derived pyrido[2,3-d]pyrimidine ring systems supported with chemotherapeutically active functionalities, is described. They were evaluated for their in vitro cytotoxic effects against th
Externí odkaz:
https://doaj.org/article/06a85e532d1b40c6987246ddf7d50625
Autor:
Ahmed H. Moustafa, Sherif A. F. Rostom, Maan T. Khayat, Ayat K Saad El-Deen, Tarek S. Ibrahim, Siva S. Panda, Hassan A. El-Sayed, Amany M.M. Al-Mahmoudy
Publikováno v:
Medicinal Chemistry. 14:791-808
Background Viral diseases are considered main threats that face the humanity worldwide. The emergence of new viruses like influenza viruses emphasizes the significance of designing novel antiviral drugs. Method The aim of this work is to synthesize a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eaf26792eb8830ecad80e57e8d4922
https://doi.org/10.2174/1573406414666180522123524
https://doi.org/10.2174/1573406414666180522123524
Autor:
Hoda G. Daabees, Sherif A. F. Rostom, Aya Y. Rashad, Ahmed E. Abdel Moneim, Shaymaa E. Kassab
Publikováno v:
Bioorganic Chemistry. 113:104948
Various febuxostat derivatives comprising carboxamide functionalities and different substituted heterocycles were synthesized and evaluated for their biological activities as xanthine oxidase (XO) and cyclooxygenase (COX) inhibitors. All the tested c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cad104f19a3c98de7cf8c74a7ccacd2
https://doi.org/10.1016/j.bioorg.2021.104948
https://doi.org/10.1016/j.bioorg.2021.104948
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:442-454
Two series of novel alkoxylated 2-oxo(imino)-3-pyridinecarbonitriles (structurally-relevant to some reported anticancer pyridines with phosphodiesterase 3A (PDE3A) inhibitory activity) were synthesized and evaluated for their in vitro differential tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71a25a88d953c27c07b482ff64373fb5
https://doi.org/10.1248/cpb.c16-00761
https://doi.org/10.1248/cpb.c16-00761
Publikováno v:
Current Topics in Medicinal Chemistry. 16:3569-3581
There has been considerable interest in azole-containing compounds as promising antiinflammatory agents. Designed compounds with five-membered nitrogen-containing nuclei have demonstrated good anti-inflammatory activity, indicating their potential fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f740a722fc972955a7d63ffe43193de
https://doi.org/10.2174/1568026616666160526125352
https://doi.org/10.2174/1568026616666160526125352
Publikováno v:
Archiv der Pharmazie. 348:824-834
A series of novel 1,4,6-trisubstituted-2-oxo-1,2-dihydropyridine-3-carbonitriles supported with some functionalities reported to contribute to significant chemotherapeutic potential were synthesized and evaluated for their antimicrobial and/or cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303afb75ed6b7ea0d3fb9113555cb644
https://doi.org/10.1002/ardp.201500175
https://doi.org/10.1002/ardp.201500175
Autor:
Sherif A. F. Rostom, Adnan A. Bekhit
Publikováno v:
European Journal of Medicinal Chemistry. 92:712-722
The synthesis of 18 novel pyrrolylpyridines and some derived bi-, tri- and tetracyclic ring systems using both the conventional heating and MW irradiation techniques is described. Fourteen compounds; 2 – 9 , 10 – 12 , 14 , 17 and 18 were evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fbc4db511c12b95086beeb67ca399b
https://doi.org/10.1016/j.ejmech.2015.01.023
https://doi.org/10.1016/j.ejmech.2015.01.023
Publikováno v:
European journal of medicinal chemistry. 139
Synthesis of twenty nine new 1,2,4-triazoles and some derived thiazolothiadiazoles (structurally-relevant to some reported triazoles with anticancer and/or Cdc25A/B inhibitory activities) is described in this study. The obtained NCI's in vitro antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dddf88d3074d6e0a2125b39f69b40c4
https://pubmed.ncbi.nlm.nih.gov/28803043
https://pubmed.ncbi.nlm.nih.gov/28803043
Publikováno v:
Archiv der Pharmazie. 350(5)
The synthesis and evaluation of the anti-inflammatory activity of some structure hybrids comprising basically the 5-hydroxy-3-methyl-1-phenyl-4-substituted-1H-pyrazole scaffold directly linked to a variety of heterocycles and functionalities, or annu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d38d555ba6d899c4a7ea8989e691afd3
https://pubmed.ncbi.nlm.nih.gov/28370254
https://pubmed.ncbi.nlm.nih.gov/28370254