Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sherie R. Howell"'
Autor:
Clifford S. Guy, Peter Vogel, Sebastien Gingras, Emin Kuliyev, Stephane Pelletier, Sherie R. Howell
Publikováno v:
The Journal of Neuroscience. 38:2615-2630
Members of the SCY1-like (SCYL) family of protein kinases are evolutionarily conserved and ubiquitously expressed proteins characterized by an N-terminal pseudokinase domain, centrally located Huntingtin, elongation factor 3, protein phosphatase 2A,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9ed568dbd5a32b9c9e59b7599d1d55
https://doi.org/10.1523/jneurosci.2282-17.2018
https://doi.org/10.1523/jneurosci.2282-17.2018
Autor:
Sebastien Gingras, Stephane Pelletier, Laurie R. Earls, Stanislav S. Zakharenko, Sherie R. Howell, Richard J. Smeyne
Publikováno v:
Journal of Neuroscience. 35:10510-10522
Neuronal death caused by excessive excitatory signaling, excitotoxicity, plays a central role in neurodegenerative disorders. The mechanisms regulating this process, however, are still incompletely understood. Here we show that the coated vesicle-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18260dce2f08e936a3f800088ea515d2
https://doi.org/10.1523/jneurosci.2056-14.2015
https://doi.org/10.1523/jneurosci.2056-14.2015
Publikováno v:
Molecular Cancer Therapeutics. 4:61-69
Transcriptional silencing of the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT) in a proportion of transformed cell lines is associated with methylated CpG hotspots in the MGMT 5′ flank. The goal of the study was to evaluate the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074e7dbfd2cf96aa3c5e56ae41678187
https://doi.org/10.1158/1535-7163.61.4.1
https://doi.org/10.1158/1535-7163.61.4.1
Publikováno v:
Molecular Carcinogenesis. 24:85-89
O6-Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20–30% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424b44abb82e62c361ff0afc55de879c
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<85::aid-mc2>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<85::aid-mc2>3.0.co
Publikováno v:
Blood. 88:2298-2305
Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2). Although MMC hypersensitivity is complemented in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f85065120f3237849bb0385e2d525d
https://doi.org/10.1182/blood.v88.6.2298.bloodjournal8862298
https://doi.org/10.1182/blood.v88.6.2298.bloodjournal8862298
Autor:
Megumi Funakoshi-Tago, James N. Ihle, Sebastien Gingras, Stephane Pelletier, Sherie R. Howell
Publikováno v:
Molecular and cellular biology. 26(22)
Biochemical and genetic studies have shown that Jak2 is an essential component of EpoR signal transduction which is required for normal erythropoiesis. However, whether Jak2 is the sole direct mediator of EpoR signal transduction remains controversia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c415f5006217745b1239878fecbccb6e
https://pubmed.ncbi.nlm.nih.gov/16982687
https://pubmed.ncbi.nlm.nih.gov/16982687
Publikováno v:
Molecular cancer therapeutics. 4(1)
Transcriptional silencing of the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT) in a proportion of transformed cell lines is associated with methylated CpG hotspots in the MGMT 5' flank. The goal of the study was to evaluate the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfd1b2f9e7e2456fa07797cd6c049127
https://pubmed.ncbi.nlm.nih.gov/15657354
https://pubmed.ncbi.nlm.nih.gov/15657354
Publikováno v:
International Journal of Oncology.
Transcriptional silencing of the DNA repair protein, O 6 -methylguanine-DNA methyltransferase (MGMT), occurs only in malignant or transformed cell lines, and such MGMT-deficient cells are hypersensitive to chemotherapeutic alkylating agents such as 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be8395876c034ad17ff6e26472b5848
https://doi.org/10.3892/ijo.18.6.1187
https://doi.org/10.3892/ijo.18.6.1187
Autor:
Thomas P. Brent, Linda C. Harris, Carol C. Venable, Sherie R. Howell, Joanna S. Remack, Mathew A. von Wronski
Publikováno v:
Carcinogenesis. 17(2)
Suppressed expression of the DNA repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT), characterized as the Mer - phenotype, occurs only in malignant or transformed cell lines. To investigate the relationship between the transformation proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355dd66d0e2ea2c431f47a9ccfe467d
https://pubmed.ncbi.nlm.nih.gov/8625442
https://pubmed.ncbi.nlm.nih.gov/8625442