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Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover.

Autor: Yasa S; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, the Broad Institute of M.I.T. and Harvard, Cambridge, MA, USA., Butz ES; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany., Colombo A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Chandrachud U; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA., Montore L; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA., Tschirner S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Prestel M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Sheridan SD; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Müller SA; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Groh J; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Tahirovic S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Cotman SL; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA. scotman@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital Research Institute, Boston, MA, USA. scotman@mgh.harvard.edu.; Department of Neurology, Harvard Medical School, Boston, MA, USA. scotman@mgh.harvard.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Oct 22; Vol. 7 (1), pp. 1373. Date of Electronic Publication: 2024 Oct 22.

Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment.

Autor: Shook LL; Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Thier Research Building, 903B, Boston, MA, 02114, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA., Batorsky RE; Data Intensive Studies Center, Tufts University, Boston, MA, USA., De Guzman RM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Thier Research Building, 903B, Boston, MA, 02114, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., McCrea LT; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Brigida SM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Thier Research Building, 903B, Boston, MA, 02114, USA., Horng JE; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sheridan SD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kholod O; Thayer School of Engineering and Program, Dartmouth College, Hanover, NH, USA., Cook AM; Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Li JZ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Slonim DK; Department of Computer Science, Tufts University, Medford, MA, USA., Goods BA; Thayer School of Engineering and Program, Dartmouth College, Hanover, NH, USA.; Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Perlis RH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Edlow AG; Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Thier Research Building, 903B, Boston, MA, 02114, USA. aedlow@mgh.harvard.edu.; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA. aedlow@mgh.harvard.edu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2024 Jun 25; Vol. 21 (1), pp. 163. Date of Electronic Publication: 2024 Jun 25.

Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment.

Autor: Shook LL, Batorsky RA, De Guzman RM, McCrea LT, Brigida SM, Horng JE, Sheridan SD, Kholod O, Cook AM, Li JZ, Goods BA, Perlis RH, Edlow AG

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 30. Date of Electronic Publication: 2023 Dec 30.