Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sheri M. Eaton"'
Autor:
Erica Lorenzo, Sheri M. Eaton, Julie S. Lefebvre, Stephen T. Smiley, April R. Masters, Laura Haynes, Jacob W. Hopkins
Publikováno v:
Oncotarget
Influenza and pneumonia are leading causes of death in elderly populations. With age, there is an increased inflammatory response and slower viral clearance during influenza infection which increases the risk of extended illness and mortality. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc52a24733f3fa43ce0b381efa8f5e29
https://pubmed.ncbi.nlm.nih.gov/27177221
https://pubmed.ncbi.nlm.nih.gov/27177221
Autor:
Gary M. Winslow, Lynn Ryan, Laura Haynes, David L. Woodland, Susan T. Wittmer, William W. Reiley, Sheri M. Eaton
Publikováno v:
The Journal of Immunology. 189:4451-4458
Fully functional T cells are necessary for the maintenance of protective immunity during chronic infections. However, activated T cells often undergo apoptosis or exhaustion upon chronic stimulation mediated by Ag or inflammation. T cell attrition ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3292f971cc2f791eee0f60ccc3139519
https://doi.org/10.4049/jimmunol.1201153
https://doi.org/10.4049/jimmunol.1201153
Autor:
Sheri M. Eaton, Alexander C. Maue, Julie S. Lefebvre, Laura Haynes, Paula A. Lanthier, Michael Tighe
Publikováno v:
Aging Cell. 11:732-740
CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust humoral response to an infection or vaccination. Importantly, immunosenescence affects CD4 T cell function and the accumulation of intrinsic defects de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d5908f1f33fc496aa03d5a6dad2444
https://doi.org/10.1111/j.1474-9726.2012.00836.x
https://doi.org/10.1111/j.1474-9726.2012.00836.x
Publikováno v:
Immunology. 127:373-385
The biological outcome of receptor-mediated signalling often depends on the duration of engagement. Because CD40 signalling is controlled by the regulated expression of its ligand, CD154, the mechanisms that regulate CD154 expression probably determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a03b2e1b2f4477f3f049062fbbbd5e
https://doi.org/10.1111/j.1365-2567.2008.02991.x
https://doi.org/10.1111/j.1365-2567.2008.02991.x
Autor:
Sheri M. Eaton, Ignacio J. Juncadella, Natarajan Muthusamy, Sean A. Diehl, Viswas Konasagara Nagaleekar, Juan Anguita, Colette Charland, Lee Ann Garrett-Sinha, Mercedes Rincon, Laura Haynes
Publikováno v:
The Journal of Immunology. 181:8315-8322
IP3 (inositol 1,4,5-trisphosphate) receptors (IP3Rs) regulate the release of Ca2+ from intracellular stores in response to IP3. Little is known about regulation of the expression of IP3Rs and their role during the activation of CD4 T cells. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7834049edcd27e5a8d85233e336fdb
https://doi.org/10.4049/jimmunol.181.12.8315
https://doi.org/10.4049/jimmunol.181.12.8315
Autor:
Laura Haynes, Gail E. Huston, Sheri M. Eaton, Karen Clise-Dwyer, Susan L. Swain, Stephen C. Jones, John P. Dibble
Publikováno v:
The Journal of Immunology. 180:4465-4475
Elderly people are at higher risk for infections due to declining cellular and humoral immune responses. Central to this dysfunction is the reduced responsiveness of the naive CD4+ T cell compartment. Previous data from our laboratory suggest that al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01cec9ee89208ce22e3cd33a30045f4
https://doi.org/10.4049/jimmunol.180.7.4465
https://doi.org/10.4049/jimmunol.180.7.4465
Autor:
Deborah M. Brown, Laura Haynes, Sheri M. Eaton, Dawn M. Jelley-Gibbs, Susan L. Swain, John P. Dibble
Publikováno v:
The Journal of Experimental Medicine
The kinetics of presentation of influenza virus–derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee71db5978265faf3221e1d45d429c5
https://doi.org/10.1084/jem.20050227
https://doi.org/10.1084/jem.20050227
Publikováno v:
The Journal of Experimental Medicine
Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced proliferation and IL-2 production in response to the antigen compared with cells from young mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e870ce0811a746554cd367e07d69d182
http://europepmc.org/articles/PMC2213095
http://europepmc.org/articles/PMC2213095
Publikováno v:
The Journal of Experimental Medicine
With increasing age, the ability to produce protective antibodies in response to immunization declines, leading to a reduced efficacy of vaccination in the elderly. To examine the effect of age on the cognate function of CD4 T cells, we have used a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8b5a9aa3a59efe62247443702a835c
https://doi.org/10.1084/jem.20041395
https://doi.org/10.1084/jem.20041395
Publikováno v:
The Journal of Immunology. 172:5194-5199
Age-related decreases in immune function are thought to contribute to the reduced efficacy of vaccinations seen in elderly populations. Our previous in vitro studies demonstrated that naive CD4 T cells from aged TCR-transgenic mice proliferate less t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360f9fdfd86382b4cf4399aafff7470d
https://doi.org/10.4049/jimmunol.172.9.5194
https://doi.org/10.4049/jimmunol.172.9.5194