Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sheri L. Shamblin"'
Autor:
Nada Mehio, Heather L. Frericks Schmidt, Geoffrey P.F. Wood, Bruno C. Hancock, Ravi M. Shanker, Jeremy A. Bartlett, Sheri L. Shamblin
Publikováno v:
International journal of pharmaceutics. 623
Multiparticulate formulations allow for the design of specialized pharmaceutical dosage forms that cater to the needs of a wide range of patient demographics, such as pediatric and geriatric populations, by affording control over the release rate and
Autor:
Varun Kushwah, Diogo Gomes Lopes, Isha Saraf, Ioannis Koutsamanis, Bernd Werner, Klaus Zangger, Michael C. Roy, Jeremy A. Bartlett, Heather Frericks Schmidt, Sheri L. Shamblin, Peter Laggner, Amrit Paudel
Publikováno v:
Molecular pharmaceutics. 19(2)
The present study systematically investigates the effect of annealing conditions and the Kolliphor P 407 content on the physicochemical and structural properties of Compritol (glyceryl behenate) and ternary systems prepared via melt cooling (Kollipho
Autor:
Kenneth S. Ogueri, Sheri L. Shamblin
Publikováno v:
Trends in biotechnology. 40(5)
In recent years, oral osmotic tablets have sparked a therapeutic paradigm for controlled-release dosage forms due to their intrinsic insensitivity to physiological and physicochemical factors. Despite these benefits, the design of an optimal osmotic
Autor:
Suman Luthra, Kapildev K. Arora, Sheri L. Shamblin, Joseph F. Krzyzaniak, Mitulkumar A. Patel, Lynne S. Taylor
Publikováno v:
Crystal Growth & Design. 18:7027-7040
Salt disproportionation is a major issue for pharmaceutical products containing a salt form of a weakly basic drug, because conversion to the free base during processing or storage in the presence of excipients may negatively impact stability and bio
Autor:
Heather Frericks Schmidt, Pankaj Doshi, Sheri L. Shamblin, Ioan Ardelean, Avik Sarkar, Amrit Paudel, Ioannis Koutsamanis, Mary T. am Ende, Varun Kushwah, Harald Plank, Peter Laggner, Diogo Gomes Lopes, Andrew Prpich
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 147
The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the matrix of glyceryl behenate and poloxamer (pore former). The solid-state, morphology, and
Autor:
Joseph F. Krzyzaniak, Suman Luthra, Lynne S. Taylor, Mitulkumar A. Patel, Sheri L. Shamblin, Kapildev K. Arora
Publikováno v:
Molecular Pharmaceutics. 15:40-52
Approximately 50% of solid oral dosage forms utilize salt forms of the active pharmaceutical ingredient (API). A major challenge with the salt form is its tendency to disproportionate to produce the un-ionized API form, decreasing the solubility and
Publikováno v:
Advanced Drug Delivery Reviews. 100:194-211
Crystalline mesophases, which are commonly classified according to their translational, orientational, and conformational order as liquid crystals, plastic crystals, and conformationally disordered crystals, represent a common state of condensed matt
Autor:
Mitulkumar A. Patel, Sheri L. Shamblin, Lynne S. Taylor, Joseph F. Krzyzaniak, Kapildev K. Arora, Suman Luthra
Publikováno v:
International journal of pharmaceutics. 546(1-2)
Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient selection is critical, as some excipients are known to cause salt dis
Autor:
Charles F Wright, Theodore E. Liston, Rosalina Destito, Alexander V. Kuperman, Lawrence A. Reiter, Kelvin Cooper, Deborah Malloy, Fiese Eugene F, Anthony Michael Campeta, David Young Mitchell, Wayne E. Barth, Sheri L. Shamblin, Fred C. Falkner, John J. Martin, Frank W. Rusek, Diane Lynn Johnson, Ralph P. Robinson, B. J. Cronin, Kathleen M. Donahue
Publikováno v:
Journal of Medicinal Chemistry. 61:3237-3237
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery of the (alpha-L-alanyloxy)-methyl ether and hemifumarate derivatives of 1 which deliver th
Autor:
Bruce C. MacDonald, Patrick Lukulay, Anthony J. Carella, Michael Christopher Roy, Michael J. Gumkowski, Sheri L. Shamblin, Kenneth Craig Waterman
Publikováno v:
Pharmaceutical Research. 24:780-790
To propose and test a new accelerated aging protocol for solid-state, small molecule pharmaceuticals which provides faster predictions for drug substance and drug product shelf-life. The concept of an isoconversion paradigm, where times in different