Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sheri K Wilcox"'
Autor:
Michael R Mehan, Deborah Ayers, Derek Thirstrup, Wei Xiong, Rachel M Ostroff, Edward N Brody, Jeffrey J Walker, Larry Gold, Thale C Jarvis, Nebojsa Janjic, Geoffrey S Baird, Sheri K Wilcox
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35157 (2012)
Lung cancer remains the most common cause of cancer-related mortality. We applied a highly multiplexed proteomic technology (SOMAscan) to compare protein expression signatures of non small-cell lung cancer (NSCLC) tissues with healthy adjacent and di
Externí odkaz:
https://doaj.org/article/6c70109d4c0145bba5f5c927743ece35
Autor:
Stephan Kraemer, Jonathan D Vaught, Christopher Bock, Larry Gold, Evaldas Katilius, Tracy R Keeney, Nancy Kim, Nicholas A Saccomano, Sheri K Wilcox, Dom Zichi, Glenn M Sanders
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26332 (2011)
Recently, we reported a SOMAmer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life-
Externí odkaz:
https://doaj.org/article/660cbe7bdb6749a2a78713066bc2e12b
Autor:
Larry Gold, Deborah Ayers, Jennifer Bertino, Christopher Bock, Ashley Bock, Edward N Brody, Jeff Carter, Andrew B Dalby, Bruce E Eaton, Tim Fitzwater, Dylan Flather, Ashley Forbes, Trudi Foreman, Cate Fowler, Bharat Gawande, Meredith Goss, Magda Gunn, Shashi Gupta, Dennis Halladay, Jim Heil, Joe Heilig, Brian Hicke, Gregory Husar, Nebojsa Janjic, Thale Jarvis, Susan Jennings, Evaldas Katilius, Tracy R Keeney, Nancy Kim, Tad H Koch, Stephan Kraemer, Luke Kroiss, Ngan Le, Daniel Levine, Wes Lindsey, Bridget Lollo, Wes Mayfield, Mike Mehan, Robert Mehler, Sally K Nelson, Michele Nelson, Dan Nieuwlandt, Malti Nikrad, Urs Ochsner, Rachel M Ostroff, Matt Otis, Thomas Parker, Steve Pietrasiewicz, Daniel I Resnicow, John Rohloff, Glenn Sanders, Sarah Sattin, Daniel Schneider, Britta Singer, Martin Stanton, Alana Sterkel, Alex Stewart, Suzanne Stratford, Jonathan D Vaught, Mike Vrkljan, Jeffrey J Walker, Mike Watrobka, Sheela Waugh, Allison Weiss, Sheri K Wilcox, Alexey Wolfson, Steven K Wolk, Chi Zhang, Dom Zichi
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15004 (2010)
The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine.We present a new aptamer-based proteomic technology for biomarker discovery capable of simultane
Externí odkaz:
https://doaj.org/article/60cf7be12d92486ea0f48de33701edfa
Autor:
Mihir A Kamat, Robert M. Plenge, An Chi, Nicholas W. Morrell, Adam S. Butterworth, James E. Peters, Heiko Runz, Joseph C. Maranville, James A. Blackshaw, James R Staley, Caroline S. Fox, Clare Oliver-Williams, Ellie Paige, Benjamin B. Sun, Tao Jiang, Angela M. Wood, John Danesh, John A. Todd, Stephen Burgess, John Bradley, David Stacey, Sheri K. Wilcox, Nebojsa Janjic, Narinder Bansal, Bram P. Prins, Sarah L. Spain, Willem H. Ouwehand, Praveen Surendran, Erik S Zimmerman, Nicole Soranzo, David J. Roberts, Dirk S. Paul, Karsten Suhre
Publikováno v:
Sun, B B, Maranville, J C, Peters, J E, Stacey, D, Staley, J R, Blackshaw, J, Burgess, S, Jiang, T, Paige, E, Surendran, P, Oliver-Williams, C, Kamat, M A, Prins, B P, Wilcox, S K, Zimmerman, E S, Chi, A, Bansal, N, Spain, S L, Wood, A M, Morrell, N W, Bradley, J R, Janjic, N, Roberts, D J, Ouwehand, W H, Todd, J A, Soranzo, N, Suhre, K, Paul, D S, Fox, C S, Plenge, R M, Danesh, J, Runz, H & Butterworth, A S 2018, ' Genomic atlas of the human plasma proteome ', Nature, vol. 558, no. 7708, pp. 73-79 . https://doi.org/10.1038/s41586-018-0175-2
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885b8d5e36c047828147323f5f115941
http://www.scopus.com/inward/record.url?scp=85048231672&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85048231672&partnerID=8YFLogxK
Autor:
Dirk S. Paul, Joseph C. Maranville, Sarah L. Spain, Ellie Paige, Karsten Suhre, Caroline S. Fox, Bradley, Benjamin B. Sun, Praveen Surendran, David J. Roberts, James E. Peters, Clare Oliver-Williams, John Danesh, David Stacey, Mihir A Kamat, Nebojsa Janjic, Robert M. Plenge, An Chi, Narinder Bansal, Tao Jiang, Angela M. Wood, Erik S Zimmerman, Bram P. Prins, Willem H. Ouwehand, Stephen Burgess, James A. Blackshaw, Heiko Runz, John A. Todd, Sheri K. Wilcox, Adam S. Butterworth, Staley, Nicole Soranzo, Nicholas W. Morrell
Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels. Here we reveal the genetic architecture of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b569fb6310fc77ef66c6c445b76fbdc
Publikováno v:
New Biotechnology. 29:543-549
In 1997, while still working at NeXstar Pharmaceuticals, several of us made a proteomic bet. We thought then, and continue to think, that proteomics offers a chance to identify disease-specific biomarkers and improve healthcare. However, interrogatin
Autor:
Thale C. Jarvis, Geoffrey S. Baird, Chi Zhang, Allison Weiss, Nebojsa Janjic, Derek Thirstrup, Amy Gelinas, Daniel J. Schneider, Sheri K. Wilcox, Jeffrey D. Carter, Shashi Kumar Gupta
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 19:273-278
Immunohistochemistry is used in both research and clinical settings to identify proteins in tissue samples. Despite the power and versatility of immunohistochemistry, limitations are imposed by the slow diffusion of antibodies through tissue and the
Publikováno v:
Genetic Engineering & Biotechnology News. 36:22-23
Autor:
Mallika Sastry, David B. Goodin, John W. Blankenship, Christopher D. Putnam, Duncan E. McRee, Walter J. Chazin, Sheri K. Wilcox
Publikováno v:
Biochemistry. 37:16853-16862
The design of a series of functionally active models for manganese peroxidase (MnP) is described. Artificial metal binding sites were created near the heme of cytochrome c peroxidase (CCP) such that one of the heme propionates could serve as a metal
Autor:
Daniel S Rivera, Vic E. Myer, Jefferson Parker, Lisa Quinn, Sheri K. Wilcox, Feng Cong, William R. Tschantz, Susanne E. Swalley, Peter LeMotte, Xiaomo Jiang, Andreas Loew, Bo Lu, Christopher A. Dimitri, Melissa Ramones, Olga Charlat, Yang Xie, Jeffrey A. Porter, Mike Watrobka, Brian Granda, Raffaella Zamponi, Doug Jeffery
Publikováno v:
EMBO reports. 14(12)
R-spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have been proposed as potential receptors of R-spondin, including LGR4/5, membrane E3 ubiquitin ligases ZNRF3/RNF43 and several