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Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response

Autor: Webster, Holly C., Gamino, Virginia, Andrusaite, Anna T., Ridgewell, Olivia, McCowan, Jack, Shergold, Amy L., Heieis, Graham A., Milling, Simon W.F., Maizels, Rick M., Perona-Wright, Georgia

Type 2 immunity is activated in response to both allergens and helminth infection. It can be detrimental or beneficial, and there is a pressing need to better understand its regulation. The immunosuppressive cytokine IL-10 is known as a T helper 2 (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3750376227b83b662333f42ad75f8150
https://eprints.gla.ac.uk/268078/2/268078.pdf

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Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.

Autor: Mahmood M; Cancer Research UK Beatson Institute, Glasgow, UK., Liu EM; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shergold AL; Cancer Research UK Beatson Institute, Glasgow, UK., Tolla E; Cancer Research UK Beatson Institute, Glasgow, UK., Tait-Mulder J; Cancer Research UK Beatson Institute, Glasgow, UK., Huerta Uribe A; Cancer Research UK Beatson Institute, Glasgow, UK., Shokry E; Cancer Research UK Beatson Institute, Glasgow, UK., Young AL; Cancer Research UK Beatson Institute, Glasgow, UK., Lilla S; Cancer Research UK Beatson Institute, Glasgow, UK., Kim M; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Park T; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Manchon JL; Centro Nacional de Investigaciones Oncológicas(CNIO), Madrid, Spain., Rodríguez-Antona C; Centro Nacional de Investigaciones Oncológicas(CNIO), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Madrid, Spain., Walters RC; Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, The University of York, York, UK., Springett RJ; Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, The University of York, York, UK., Blaza JN; Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, The University of York, York, UK., Zanivan S; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, UK., Sumpton D; Cancer Research UK Beatson Institute, Glasgow, UK., Roberts EW; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, UK., Reznik E; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gammage PA; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 23. Date of Electronic Publication: 2023 Mar 23.