Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Sherer, Brian A."'
Autor:
Toure, Momar, Johnson, Theresa, Li, Bin, Schmidt, Ralf, Ma, Hong, Neagu, Constantin, Lopez, Andrea Unzue, Wang, Yanping, Guler, Satenig, Xiao, YuFang, Henkes, Renate, Ho, Kevin, Zhang, Susan, Chu, Chia Lin, Gundra, Uma Mahesh, Porichis, Filippos, Li, Long, Maurer, Christine Katharina, Fang, Zhizhou, Musil, Djordje, DiPoto, Maria, Friis, Emily, Jones, Reinaldo, Jones, Christopher, Cummings, James, Chekler, Eugene, Tanzer, Eva Maria, Huck, Bayard, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry 7 September 2023 92
Autor:
Qiu, Hui, Ali, Zahid, Bender, Andrew, Caldwell, Richard, Chen, Yi-Ying, Fang, Zhizhou, Gardberg, Anna, Glaser, Nina, Goettsche, Anja, Goutopoulos, Andreas, Grenningloh, Roland, Hanschke, Bettina, Head, Jared, Johnson, Theresa, Jones, Christopher, Jones, Reinaldo, Kulkarni, Shashank, Maurer, Christine, Morandi, Federica, Neagu, Constantin, Poetzsch, Sven, Potnick, Justin, Schmidt, Ralf, Roe, Katherine, Viacava Follis, Ariele, Wing, Carolyn, Zhu, Xiaohua, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 June 2021 40
Akademický článek
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Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Autor:
Uria-Nickelsen, Maria, Blodgett, April, Kamp, Heather, Eakin, Ann, Sherer, Brian, Green, Oluyinka
Publikováno v:
In International Journal of Antimicrobial Agents January 2013 41(1):28-35
Autor:
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 July 2022 67
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity
Autor:
Melinda Przetak, Aditee Deshpande, Simone C. Zimmerli, Noune Tahmassian Morse, Evgeni Tzvetkov, Albertina Pereira, Sonja Reissig, Robert L. Walsky, Shinji L. Okitsu, Philipp Haselmayer, Djordje Musil, Sherer Brian A, Jaromir Vlach, Theresa L. Johnson, Andrew Bender
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:397-409
Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production, which is normally a protective host response. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963e63bf34625b4b6f50f0a262d440b1
https://doi.org/10.1124/jpet.120.000275
https://doi.org/10.1124/jpet.120.000275
Autor:
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 October 2021 50
Autor:
Ruoxi Lan, Hui Tian, Dusica Santos, Lizbeth Celeste Deselm, Jing Lin, Donald Bankston, Constantin Neagu, Sherer Brian A, Jennifer Jackson, Jared Head, Jianguo Ma, Xuliang Jiang, Sakeena Syed, Anderson Clark, Andreas Machl, Yufang Xiao, Erik Wilker, Anna Gardberg, Xiaoling Chen, Igor Mochalkin, Bayard R. Huck, Hui Qiu, Christopher Charles Victor Jones, Vikram Dutt, Johnson Theresa L, Andreas Goutopoulos
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Activation of the PI3K/Akt/mTOR kinase pathway is associated with human cancers. A dual p70S6K/Akt inhibitor is sufficient to inhibit strong tumor growth and to block negative impact of the compensatory Akt feedback loop activation. A scaffold dockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c34ccf70712c4f9a6c835cbbed5b0bb
https://pubmed.ncbi.nlm.nih.gov/35484006
https://pubmed.ncbi.nlm.nih.gov/35484006
Akademický článek
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