Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shereen Nizari"'
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Autor:
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Iván Ruminot, Mark F. Lythgoe, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.
Externí odkaz:
https://doaj.org/article/0e7fd82c54eb4eecb447c0bf5d5c893f
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/4cc6aded39dc46ac980ebcc2b865f356
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood
Externí odkaz:
https://doaj.org/article/ee868e90148f4c68b184f20760ef4db9
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Compelling experimental and clinical evidence supports a role for maternal obesity in offspring health. Adult children of obese mothers are at greater risk of obesity, diabetes, coronary heart disease and stroke. These offspring may also be at greate
Externí odkaz:
https://doaj.org/article/ff598a9e24a44aab8cdab891fa00ac1e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Increasing evidence supports a role for cerebrovasculature dysfunction in the etiology of Alzheimer’s disease (AD). Blood vessels in the brain are composed of a collection of cells and acellular material that comprise the neurovascular unit (NVU).
Externí odkaz:
https://doaj.org/article/e0126da7cfbc4bdf9d53e22d958468db
Autor:
Philippa Chapman, Sean M. Davidson, Stefan Trapp, Isabel N. Christie, Shereen Nizari, Derek M. Yellon, Nils Korte, Alla S. Korsak, Marina Basalay, Alexander V. Gourine, Shefeeq M. Theparambil, Frank Reimann
Publikováno v:
Basic Research in Cardiology
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments: remote ischaemic condi
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow (CBF
Autor:
Patrick S, Hosford, Jack A, Wells, Shereen, Nizari, Isabel N, Christie, Shefeeq M, Theparambil, Pablo A, Castro, Anna, Hadjihambi, L Felipe, Barros, Iván, Ruminot, Mark F, Lythgoe, Alexander V, Gourine
Publikováno v:
Nature communications. 13(1)
Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal
Publikováno v:
Clinical Science. 131:1207-1214
Neuronal death is a hallmark of Alzheimer's disease (AD) and considerable work has been done to understand how the loss of interconnectivity between neurons contributes to the associated dementia. Often overlooked however, is how the loss of neuronal