Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Shereen Kadir"'
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Nicola Rath, Jennifer P Morton, Linda Julian, Lena Helbig, Shereen Kadir, Ewan J McGhee, Kurt I Anderson, Gabriela Kalna, Margaret Mullin, Andreia V Pinho, Ilse Rooman, Michael S Samuel, Michael F Olson
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 2, Pp 198-218 (2016)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in
Externí odkaz:
https://doaj.org/article/965beffc5d8b4fb09500eba6469b356a
Autor:
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent me
Externí odkaz:
https://doaj.org/article/df26cad288c04a3b996446d05fb3fd9a
The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues
Autor:
Anna-Karin E. Johnsson, Yanfeng Dai, Max Nobis, Martin J. Baker, Ewan J. McGhee, Simon Walker, Juliane P. Schwarz, Shereen Kadir, Jennifer P. Morton, Kevin B. Myant, David J. Huels, Anne Segonds-Pichon, Owen J. Sansom, Kurt I. Anderson, Paul Timpson, Heidi C.E. Welch
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 1153-1164 (2014)
The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific cell morphologies and responses. Here, we have generated a mouse strain, Rac-FRET, which ub
Externí odkaz:
https://doaj.org/article/8bdba94a3f9d43c791b34b84ce9c7d0a
Autor:
Michael S. Samuel, Margaret Mullin, Ilse Rooman, Linda Julian, Jennifer P. Morton, Lena Helbig, Nicola Rath, Ewan J. McGhee, Michael F. Olson, Shereen Kadir, Kurt I. Anderson, Gabriela Kalna, Andreia V. Pinho
Publikováno v:
EMBO Molecular Medicine
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in human an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322cbe125886e217938224886a9c3884
http://europepmc.org/articles/PMC5286371
http://europepmc.org/articles/PMC5286371
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, Tatyana Chtanova, Marina Pajic, Douglas Strathdee, Peter W. Gunning, Stacey N. Walters, Peter I. Croucher, Juliane P. Schwarz, Edna C. Hardeman, Julian M. W. Quinn, Kurt I. Anderson, Alice Boulghourjian, Agata Mrowinska, James R.W. Conway, Owen J. Sansom, Christopher J. Ormandy, Nadine Reischmann, David Herrmann, Paul Timpson, Monica J. Killen, Heidi C.E. Welch, Lei Zhang, Jennifer P. Morton, Michael S. Samuel, Andrius Masedunskas, Claire Vennin, Paul A. Baldock, Shereen Kadir, Jacqueline Bailey, Anna-Karin E. Johnsson, Richard P. Harvey, Andrew M. K. Law, Wilfred Leung, Ewan J. McGhee, Morghan C. Lucas, Gonzalo del Monte-Nieto, Anaiis Zaratzian, Herbert Herzog, Astrid Magenau, David A. Stevenson, Shane T. Grey, Sean C. Warren, David Gallego-Ortega
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5ae14f85f6dbaec756cfb97ddafd72
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues
Autor:
Max Nobis, Owen J. Sansom, Anne Segonds-Pichon, Martin J. Baker, Heidi C.E. Welch, Kevin Myant, Kurt I. Anderson, Shereen Kadir, Jennifer P. Morton, Simon Walker, Juliane P. Schwarz, Paul Timpson, Anna-Karin E. Johnsson, David J. Huels, Ewan J. McGhee, Yanfeng Dai
Publikováno v:
Cell Reports; Vol 6
Cell Reports, Vol 6, Iss 6, Pp 1153-1164 (2014)
Cell Reports
Cell Reports, Vol 6, Iss 6, Pp 1153-1164 (2014)
Cell Reports
Summary The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific cell morphologies and responses. Here, we have generated a mouse strain, Rac-FRET,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0c39754b500f5bab67673b39e76aeb
Publikováno v:
Journal of Cell Science. 124:2642-2653
When migrating mesenchymal cells collide, they exhibit a ‘contact inhibition of locomotion’ response that results in reversal of their front–rear polarity by extension of a new leading edge, which enables their migration away from the opposing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ea7f60bc8dc850f95f5d308d8f14e8
https://doi.org/10.1242/jcs.087965
https://doi.org/10.1242/jcs.087965
Autor:
Shane T. Grey, Claire Vennin, Lei Zhang, Sean C. Warren, Owen J. Sansom, Herbert Herzog, Stacey N. Walters, Saadia A. Karim, T.R. Jeffry Evans, Zahra Erami, Paul Timpson, Kendelle J. Murphy, Kurt I. Anderson, Andrew D. Campbell, David Gallego-Ortega, David R. Croucher, Astrid Magenau, Juliane P. Schwarz, Max Nobis, Shereen Kadir, Peter W. Gunning, Wilfred Leung, Agata Mrowinska, James R.W. Conway, Nadine Reischmann, David Herrmann, Morghan C. Lucas, Andrew M. K. Law, Ewan J. McGhee, Edna C. Hardeman, Jennifer P. Morton, Douglas Strathdee, Christopher J. Ormandy, Rachel A. Ridgway
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
Cell Reports
Cell Reports
Summary E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8c2ab260035e49af9f81a6b2805460
https://hdl.handle.net/10453/156224
https://hdl.handle.net/10453/156224
Autor:
Morghan C. Lucas, Jennifer P. Morton, David Gallego-Ortega, Claire Vennin, Owen J. Sansom, Paul Timpson, Saadia A. Karim, Jeffry Evans, Nadine Reischmann, Zahra Erami, Kurt I. Anderson, Andrew D. Campbell, Sean C. Warren, Shereen Kadir, Juliane P. Schwarz, Max Nobis, Wilfred Leung, David Herrmann, Ewan J. McGhee, Astrid Magenau, Agata Mrowinska
Publikováno v:
Cancer Research. 77:PR07-PR07
E-cadherin-mediated cell-cell junctions play a physical role in maintaining normal epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83317ae8ee0bcd78474dc505a817ee4e
https://doi.org/10.1158/1538-7445.epso16-pr07
https://doi.org/10.1158/1538-7445.epso16-pr07