Výsledky vyhledávání - "Sheree Darang"

Abstract A177: Phase 1, dose-escalation, safety, pharmacokinetic and pharmacodynamic study of single agent PF-03758309, an oral PAK inhibitor, in patients with advanced solid tumors

Autor: Todd Andrew Blumenkopf, Jorge Gallo, Linda Mileshkin, Jonathan H. Goldman, Sheree Darang, Lee S. Rosen, S. Gail Eckhardt, Diane Wang, Aurora Breazna

Publikováno v: Molecular Cancer Therapeutics. 10:A177-A177

Background: P21 activated kinase (PAK), a family of serine-threonine kinases, is a downstream effector of the Rho family and functions as a signaling node for various oncogenic pathways. The capability to transform cell cultures and the consistent an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d16f92908cdc6c37e483af72315b014
https://doi.org/10.1158/1535-7163.targ-11-a177

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