Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sheree D. Martin"'
Autor:
Liam G. Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A. Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure. Here we show that adipose tissue
Externí odkaz:
https://doaj.org/article/ade282758ba44938be3e4d25c0c6bdc1
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Autor:
Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased h
Externí odkaz:
https://doaj.org/article/cb089318d6ca4cdc83eb1a778a2e7a37
Autor:
Sheree D. Martin, Sean L. McGee
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival. As such, targeting this metabolic reprograming has received much attention
Externí odkaz:
https://doaj.org/article/24b3b8ab3ed2423390b57cb30ab2f288
Autor:
Kirstie A. De Jong, Liam G. Hall, Mark C. Renton, Timothy Connor, Sheree D. Martin, Greg M. Kowalski, Christopher S. Shaw, Clinton R. Bruce, Kirsten F. Howlett, Sean L. McGee
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101105- (2020)
Objective: Protein kinase D (PKD) signaling has been implicated in stress-induced cardiac remodeling and function as well as metabolic processes including contraction-mediated cardiac glucose uptake. PKD has recently emerged as a nutrient-sensing kin
Externí odkaz:
https://doaj.org/article/f19a389a4e5441999563302ccad50888
Autor:
Vidhi Gaur, Timothy Connor, Andrew Sanigorski, Sheree D. Martin, Clinton R. Bruce, Darren C. Henstridge, Simon T. Bond, Kevin A. McEwen, Lyndal Kerr-Bayles, Trent D. Ashton, Cassandra Fleming, Min Wu, Lisa S. Pike Winer, Denise Chen, Gregg M. Hudson, John W.R. Schwabe, Keith Baar, Mark A. Febbraio, Paul Gregorevic, Frederick M. Pfeffer, Ken R. Walder, Mark Hargreaves, Sean L. McGee
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2802-2810 (2016)
Drugs that recapitulate aspects of the exercise adaptive response have the potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) tra
Externí odkaz:
https://doaj.org/article/edcebf20f6354f6bb76e658132df2dd0
Autor:
H. M. P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Aya C. Taki, Russell S. Addison, Sasha Hayes, Karren D. Beattie, Sean L. McGee, Sheree D. Martin, Merrick G. Ekins, John N. A. Hooper, Bill C. H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 598 (2019)
There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importance to circumvent challenges linked to drug resistant parasites. Being one of the most diverse natural ecosystems, the mar
Externí odkaz:
https://doaj.org/article/3e28cf7ce12e43adb4bcb94d81ae4d7a
Autor:
Manuel A. Fernández-Rojo, Milena Gongora, Rebecca L. Fitzsimmons, Nick Martel, Sheree D. Martin, Susan J. Nixon, Andrew J. Brooks, Maria P. Ikonomopoulou, Sally Martin, Harriet P. Lo, Stephen A. Myers, Christina Restall, Charles Ferguson, Paul F. Pilch, Sean L. McGee, Robin L. Anderson, Michael J. Waters, John F. Hancock, Sean M. Grimmond, George E.O. Muscat, Robert G. Parton
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 238-247 (2013)
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolis
Externí odkaz:
https://doaj.org/article/626b24aa557c4a558809186d6302745e
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Autor:
Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee
Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased histone de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75b6269684266e0bcc8f17692dacff11
https://doi.org/10.1101/2022.10.17.512492
https://doi.org/10.1101/2022.10.17.512492
Autor:
Liam G Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Aβ42) in these diverse chronic diseases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713650f077407ca0d354131f4b65baa
https://doi.org/10.1101/2022.10.02.510555
https://doi.org/10.1101/2022.10.02.510555
Autor:
Nghi H. Nguyen, Abdul Jabbar, Fei Huang, Sean L. McGee, Yaqing Jiao, Abhijit Kundu, Michael J. Palmer, Banfeng Ruan, Bill C.H. Chang, Thuy G. Le, Jonathan B. Baell, Liam G. Hall, Atanu Ghoshal, Lian Xue, Jose F. Garcia-Bustos, Robin B. Gasser, Timothy N. C. Wells, Sarah Preston, Sheree D. Martin
Publikováno v:
Journal of Medicinal Chemistry. 64:840-844
A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the parasitic nematode of sheep, Haemonchus contortus. These compounds did not show overt cytotoxicity to a range of mammalian cell lines under standard in vitro