Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sheree A. Wek"'
Autor:
Danni Jin, Sheree A. Wek, Ricardo A. Cordova, Ronald C. Wek, Didier Lacombe, Vincent Michaud, Karin Musier‐Forsyth
Publikováno v:
Clinical Genetics. 103:358-363
Aminoacyl-tRNA synthetases are enzymes that ensure accurate protein synthesis. Variants of the dual-functional cytoplasmic human glutamyl-prolyl-tRNA synthetase, EPRS1, have been associated with leukodystrophy, diabetes and bone disease. Here, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9becd3aaa3bcbc40ad7400b042594ce1
https://doi.org/10.1111/cge.14269
https://doi.org/10.1111/cge.14269
Autor:
Karin Musier-Forsyth, Ronald C. Wek, Sheree A. Wek, Marina Bakhtina, William A. Cantara, Nathan T. Kudlapur, Danni Jin
Publikováno v:
The Journal of Biological Chemistry
Aminoacyl-tRNA synthetases (ARSs) catalyze the charging of specific amino acids onto cognate tRNAs, an essential process for protein synthesis. Mutations in ARSs are frequently associated with a variety of human diseases. The human EPRS1 gene encodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce97fb563092e3b298c457fe5bda992
http://europepmc.org/articles/PMC8511952
http://europepmc.org/articles/PMC8511952
Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase
Autor:
Rachel B. Reinert, Margaret A. McNurlan, Donald L. Durden, Tracy G. Anthony, Izolda Mileva, Xue Ping Wang, Piyawan Bunpo, Leslie O. Goodwin, Sheree A. Wek, Ronald C. Wek, Carla J. Aldrich, L. Morgan Oberle
Publikováno v:
Journal of Biological Chemistry. 281:31222-31233
l-Asparaginase is important in the induction regimen for treating acute lymphoblastic leukemia. Cytotoxic complications are clinically significant problems lacking mechanistic insight. To reveal tissue-specific molecular responses to this drug, mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79e52a9f7b225445af475e868cb7fad
https://doi.org/10.1016/s0021-9258(19)84035-8
https://doi.org/10.1016/s0021-9258(19)84035-8
Autor:
Hongzhen He, Ronald C. Wek, Millie M. Georgiadis, Isha Singh, Sheree A. Wek, Souvik Dey, Thomas D. Baird
Publikováno v:
The Journal of biological chemistry. 289(21)
In response to amino acid starvation, GCN2 phosphorylation of eIF2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress. GCN2 is a multidomain protein with key regulatory domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d183bdb2b62aa7f300b9a6edc44b2ea1
https://pubmed.ncbi.nlm.nih.gov/24719324
https://pubmed.ncbi.nlm.nih.gov/24719324
Autor:
Brian F. Teske, Ronald C. Wek, Tracy G. Anthony, Jeanette N. McClintick, Piyawan Bunpo, Sheree A. Wek, Judy K. Cundiff
Publikováno v:
Molecular Biology of the Cell
This study shows that the eIF2 kinase PERK is required not only for translational control but also for activation of ATF6 and its target genes in the unfolded protein response. The PERK pathway facilitates both the synthesis of ATF6 and trafficking o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cc974f41a5557332aaa132302889a9
https://pubmed.ncbi.nlm.nih.gov/21917591
https://pubmed.ncbi.nlm.nih.gov/21917591
Autor:
Sheree A. Wek, Constantine Londos, Malcolm Moos, Andrew S. Greenberg, Min-Kun Chang, John J. Egan
Publikováno v:
Proceedings of the National Academy of Sciences. 89:8537-8541
Hormone-sensitive lipase activity (HSL), which is found in the supernatant of centrifuged homogenates of lipolytically quiet isolated rat adipocytes, was greatly reduced in or absent from the supernatant of lipolytically stimulated cells. The lipase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d46f230a21e676379137aa48ce3963
https://doi.org/10.1073/pnas.89.18.8537
https://doi.org/10.1073/pnas.89.18.8537
Autor:
Sheree A. Wek, Kimberly A. Dittmar, Li Jiang, Ronald C. Wek, Florien Freimoser, Tao Pan, Jana Narasimhan, John M. Zaborske
Publikováno v:
The Journal of biological chemistry. 284(37)
When cells are subjected to nutritional stress, uncharged tRNAs accumulate and activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general amino acid control pathway. The Gcn2p regulatory domain homologous to histidyl-tRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e994b7c0046c62ffd0402cc31af3cb
https://pubmed.ncbi.nlm.nih.gov/19546227
https://pubmed.ncbi.nlm.nih.gov/19546227
Autor:
Sheree A. Wek, N B Garty, Constantine Londos, John J. Egan, E J Blanchette-Mackie, Andrew S. Greenberg
Publikováno v:
Journal of Biological Chemistry. 266:11341-11346
The lipid fraction ("fat cake") of rat epididymal adipocytes contains a prominent phosphoprotein (62 kDaapp by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) that is multiply phosphorylated by cAMP-dependent protein kinase in vivo, at whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9172e5995dad9ec296281609fb6855
https://doi.org/10.1016/s0021-9258(18)99168-4
https://doi.org/10.1016/s0021-9258(18)99168-4
Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes
Publikováno v:
Proceedings of the National Academy of Sciences. 87:1052-1056
Incubation of isolated rat adipocytes with insulin, vasopressin, or oxytocin increased plasma membrane-bound protein kinase C (PKC) activity by 100-400%. PKC activity was assayed by a procedure that is virtually background-free, thus permitting assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfbd7a505885b0ba2a551c69ff93119
https://doi.org/10.1073/pnas.87.3.1052
https://doi.org/10.1073/pnas.87.3.1052
Autor:
Barbara C. McGrath, Xiaozhong Wang, Ronald C. Wek, Heather P. Harding, Tsonwin Hai, Hao Yuan Jiang, Dan Lu, Sheree A. Wek, Douglas R. Cavener, David Ron
In response to environmental stress, cells induce a program of gene expression designed to remedy cellular damage or, alternatively, induce apoptosis. In this report, we explore the role of a family of protein kinases that phosphorylate eukaryotic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f15807c6dcf0d9ffc264aefb5d6823a
https://europepmc.org/articles/PMC321431/
https://europepmc.org/articles/PMC321431/
