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Akademický článek

Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury

Autor: Adam Doelman, Seth Tigchelaar, Brian McConeghy, Sunita Sinha, Martin S. Keung, Neda Manouchehri, Megan Webster, Shera Fisk, Charlotte Morrison, Femke Streijger, Corey Nislow, Brian K. Kwon

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-17 (2021)

Abstract Background The gut microbiome is a diverse network of bacteria which inhabit our digestive tract and is crucial for efficient cellular metabolism, nutrient absorption, and immune system development. Spinal cord injury (SCI) disrupts autonomi

Externí odkaz: https://doaj.org/article/f9383aabaec847a3b3a54c825046071c

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Akademický článek

Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Autor: Alexandra M. Williams, Neda Manouchehri, Erin Erskine, Keerit Tauh, Kitty So, Katelyn Shortt, Megan Webster, Shera Fisk, Avril Billingsley, Alex Munro, Seth Tigchelaar, Femke Streijger, Kyoung-Tae Kim, Brian K. Kwon, Christopher R. West

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Clinical neuroprotective strategies for acute spinal cord injury (SCI) have largely overlooked the heart. Here the authors show cardiac contractility is immediately impaired in a porcine model of T2 SCI, and cardio-centric treatment with dobutamine o

Externí odkaz: https://doaj.org/article/6454cf877f514bc6be1f2dab93e7dfb0

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A cross-species validation of single-beat metrics of cardiac contractility

Publikováno v: The Journal of physiology. 600(22)

The assessment of left ventricular (LV) contractility in animal models is useful in various experimental paradigms, yet obtaining such measures is inherently challenging and surgically invasive. In a cross-species study using small and large animals,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3440fcd1c1a5f197c02c2756a7e25da
https://pubmed.ncbi.nlm.nih.gov/36285355

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Continuous Optical Monitoring of Spinal Cord Oxygenation and Hemodynamics during the First Seven Days Post-Injury in a Porcine Model of Acute Spinal Cord Injury

Autor: Seth Tigchelaar, Neda Manouchehri, Shera Fisk, Andrew J. Macnab, Megan Webster, Lorna Tu, Brian K. Kwon, Amanda Cheung, Sara S. Dalkilic, Babak Shadgan, Kyoung-Tae Kim, Kitty So, Eric C Sayre, Femke Streijger

Publikováno v: Journal of Neurotrauma. 37:2292-2301

One of the only currently available treatment options to potentially improve neurological recovery after acute spinal cord injury (SCI) is augmentation of mean arterial blood pressure (MAP) to promote blood flow and oxygen delivery to the injured cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cde585e050eafa852e196d8316ebe7
https://doi.org/10.1089/neu.2020.7086

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Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Autor: Shera Fisk, Femke Streijger, Brian K. Kwon, Katelyn Shortt, Seth Tigchelaar, Alex Munro, Christopher West, Alexandra M. Williams, Keerit Tauh, Avril Billingsley, Megan Webster, Erin Erskine, Kyoung-Tae Kim, Kitty So, Neda Manouchehri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

Chronic high-thoracic and cervical spinal cord injury (SCI) results in a complex phenotype of cardiovascular consequences, including impaired left ventricular (LV) contractility. Here, we aim to determine whether such dysfunction manifests immediatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5ed4b558d552c6e50d43fe135214ff
https://doaj.org/article/6454cf877f514bc6be1f2dab93e7dfb0

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A porcine model for studying the cardiovascular consequences of high‐thoracic spinal cord injury

Autor: Kitty So, Christopher West, Katelyn Short, Shera Fisk, Neda Manouchehri, Alexandra M. Williams, Megan Webster, Charlotte J. Morrison, Amanda Cheung, Erin Erskine, Brian K. Kwon, Malihe-Sadat Poormasjedi-Meibod, Femke Streijger

Publikováno v: The Journal of Physiology. 598:929-942

KEY POINTS We have developed a novel porcine model of high-thoracic midline contusion spinal cord injury (SCI) at the T2 spinal level. We describe this model and the ensuing cardiovascular and neurohormonal responses, and demonstrate the model is eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f88e6a603c17e6ad830484b3ea0376
https://doi.org/10.1113/jp278451

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Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency

Autor: Susan C. Menzies, Jessica Leung, Mahdis Monajemi, Rym Ben-Othman, Tobias R. Kollmann, Laura M. Sly, Bing Cai, Shera Fisk, Yvonne C. F. Pang, Jacob Rozmus

Publikováno v: Journal of Leukocyte Biology. 106:863-877

This study tested the hypothesis that mucosa associated lymphoid tissue 1 (Malt1) deficiency causes osteoporosis in mice by increasing osteoclastogenesis and osteoclast activity. A patient with combined immunodeficiency (CID) caused by MALT1 deficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d872030f264fc5ff3bbc323f63011f
https://doi.org/10.1002/jlb.5vma0219-054r

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