Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sher Karki"'
Autor:
Christine Bonzon, Rumana Rashid, Irene Leung, Nicole Rodriguez, Alex Nisthal, Ruschelle Love, Sung-Hyung Lee, Panida Lertkiatmongkol, Sher Karki, Kendra N Avery, Norman J Barlow, Seung Y Chu, Gregory L Moore, John R Desjarlais
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/0bbc3f9cd59949e18f47f70a8c932be8
Autor:
David R. Stover, John E. Dick, Thomas J. Kipps, Ingrid B.J. Joseph, Fernando Doñate, Pia M. Challita-Eid, Kendall Morrison, Zili An, Michael Y. Choi, Faisal Malik, Sung-Ju Moon, Peng Yang, Joseph D. Abad, Sher Karki, Hector Aviña, Ssucheng J. Hsu, Alla Verlinsky, Nathan Mbong, Liqing Jin, Claudia I. Guevara, Daniel S. Pereira
CD37 is a tetraspanin expressed on malignant B cells. Recently, CD37 has gained interest as a therapeutic target. We developed AGS67E, an antibody–drug conjugate that targets CD37 for the potential treatment of B/T-cell malignancies. It is a fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1527556d255efa3b01de73ceaefa5731
https://doi.org/10.1158/1535-7163.c.6536874.v1
https://doi.org/10.1158/1535-7163.c.6536874.v1
Autor:
David R. Stover, John E. Dick, Thomas J. Kipps, Ingrid B.J. Joseph, Fernando Doñate, Pia M. Challita-Eid, Kendall Morrison, Zili An, Michael Y. Choi, Faisal Malik, Sung-Ju Moon, Peng Yang, Joseph D. Abad, Sher Karki, Hector Aviña, Ssucheng J. Hsu, Alla Verlinsky, Nathan Mbong, Liqing Jin, Claudia I. Guevara, Daniel S. Pereira
Figure S1: AGS67E Binds To B-Cells With High Affinity and Induces Cytotoxicity. Figure S2: AGS67E and AGS67C Internalize Into B Cell Lymphma Cells. Figure S3: AGS67E But Not AGS67C Exhibits Anti-Tumor Activity In MOLM-13 Xenografts. Figure S4: AGS67C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a083c06965c0eadcd1fd9019b5efb71f
https://doi.org/10.1158/1535-7163.22501707
https://doi.org/10.1158/1535-7163.22501707
Autor:
Fernando Doñate, David R. Stover, Sher Karki, Hector Aviña, Lisa Do, Josh Snyder, Veronica Robles, Zhilan Zeng, Karen Morrison, Jimmy Ou, Sathish Kumar Ganesan, Sara Gulesserian, Hui Zhao
Fig. S1. Structure of AGS-16C3F; Figure S2. ENPP3 was not expressed in megakaryocytes; Figure S3. AGS-16C3F did not affect platelet activation; Figure S4. Maturing MKs did not express ENPP3; Figure S5. Fc blocker inhibited FcγRIIA pathway in tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00342acdda45c0ff67ce6d7bb2934973
https://doi.org/10.1158/1535-7163.22509028
https://doi.org/10.1158/1535-7163.22509028
The contribution of Fc-mediated effector functions to the therapeutic efficacy of some monoclonal antibodies has motivated efforts to enhance interactions with Fcγ receptors (FcγR). Although an early goal has been enhanced FcγRIIIa binding and nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6ddec74fc0186258dbe8ccbe9216ed
https://doi.org/10.1158/1535-7163.c.6530807.v1
https://doi.org/10.1158/1535-7163.c.6530807.v1
Autor:
David R. Stover, Pia M. Challita-Eid, Daniel S. Pereira, Ingrid B.J. Joseph, John Atkinson, Daulet Satpayev, Wendy Liu, Rossana Nadell, Faisal Malik, Yuriy Shostak, Ryuichi Moriya, Jimmy Ou, Peng Yang, Karen Morrison, Sher Karki, Hector Aviña, Linnette Capo, Zili An, Kendall Morrison, Arthur Raitano, Fernando Doñate
Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071a72a470db5adede0722ce6e0e19a7
https://doi.org/10.1158/1078-0432.22460346
https://doi.org/10.1158/1078-0432.22460346
Supplementary Fig. S1 from Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f5f64c8666da5483d399afbef5ec3e
https://doi.org/10.1158/1535-7163.22482026
https://doi.org/10.1158/1535-7163.22482026
Autor:
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Roland Luethy, Sung-Ju Moon, Josh Snyder, Linnette Capo, René Hubert, Hector Aviña, Sher Karki, Pia Challita-Eid, Faisal Malik, Jeffrey Coleman, Karen Morrison, Peng Yang, Jimmy Ou, Jenny Nater, Zhilan Zeng, Sara Gulesserian, John Atkinson, Hui Zhao
AGS-16C3F is an antibody–drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. AGS-16C3F and other ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15490f6d4322c9192d3919e4ad7ff9a9
https://doi.org/10.1158/0008-5472.c.6510380.v1
https://doi.org/10.1158/0008-5472.c.6510380.v1
Autor:
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Roland Luethy, Sung-Ju Moon, Josh Snyder, Linnette Capo, René Hubert, Hector Aviña, Sher Karki, Pia Challita-Eid, Faisal Malik, Jeffrey Coleman, Karen Morrison, Peng Yang, Jimmy Ou, Jenny Nater, Zhilan Zeng, Sara Gulesserian, John Atkinson, Hui Zhao
Supplemental tables 1-5: Table 1: Characteristics of peptide modified ADCs tested and IC50 in the HCEC and KU812 assays. Table 2: Characteristics. of PEG modified ADCs tested and data in the HCEC and KU812 assays. Table 3: Characteristics of mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7610130a3c9e9e7370a263155dfda9
https://doi.org/10.1158/0008-5472.22419443
https://doi.org/10.1158/0008-5472.22419443
Autor:
David R. Stover, Pia M. Challita-Eid, Daniel S. Pereira, Ingrid B.J. Joseph, John Atkinson, Daulet Satpayev, Wendy Liu, Rossana Nadell, Faisal Malik, Yuriy Shostak, Ryuichi Moriya, Jimmy Ou, Peng Yang, Karen Morrison, Sher Karki, Hector Aviña, Linnette Capo, Zili An, Kendall Morrison, Arthur Raitano, Fernando Doñate
Supplemental Table 1. Quantification of ENPP3 Expression in Various Carcinomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81085b4cbfb6ad90b94dc083d54e1849
https://doi.org/10.1158/1078-0432.22460334
https://doi.org/10.1158/1078-0432.22460334