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Autor:
Kiyohiro Ando, Sara R. Fassio, Ruth Thompson, Sheré L. Paris, Andrew Oberst, Brittany A. Rohrman, Peter H. Liu, Richa B. Shah, Chloé I. Charendoff, Lisa Bouchier-Hayes, Melissa J. Parsons, Samuel Sidi
Publikováno v:
Journal of Cell Biology. 216:1795-1810
The PIDDosome (PIDD–RAIDD–caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence