Revealing Mechanisms of Sporadic Alzheimer’s Disease by Modelling in Organotypic Hippocampal Slice Cultures

Autor: Sheppard, Olivia

Alzheimer’s disease (AD) is a devastating neurodegenerative condition which affects millions of people throughout the world. It is the most common form of dementia and manifests with progressive memory impairment and cognitive decline. While a smal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f44aafaac670b03b125582f13f80bc24

Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F

Autor: Zhang, Li, Sheppard, Olivia R., Shah, Ajay M., Brewer, Alison C.

Publikováno v: In Free Radical Biology and Medicine 2008 45(5):679-685

Molybdenum oxide nanoporous asymmetric membranes for high-capacity lithium ion battery anode.

Autor: Larson, Emilee, Williams, Logan, Jin, Congrui, Chen, Xiaobo, DiCesare, Jake, Sheppard, Olivia, Xu, Shaowen, Wu, Ji

Publikováno v: Journal of Materials Research; Jul2022, Vol. 37 Issue 13, p2204-2215, 12p

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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Autor: Wiseman, Frances K, Pulford, Laura J, Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chávez-gutiérrez, Lucia, Cleverley, Karen, Noy, Sue, Sheppard, Olivia, Collins, Toby, Powell, Caroline, Sarell, Claire J, Rickman, Matthew, Choong, Xun, Tosh, Justin L, Siganporia, Carlos, Whittaker, Heather T, Stewart, Floy, Szaruga, Maria, Murphy, Michael P, Blennow, Kaj, De Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M, Tybulewicz, Victor L J, Fisher, Elizabeth M C, Strydom, Andre, Fisher, Elizabeth, Nizetic, Dean, Hardy, John, Tybulewicz, Victor, Karmiloff-smith, Annette

Publikováno v: Wiseman, F K, Pulford, L J, Barkus, C, Liao, F, Portelius, E, Webb, R, Chávez-gutiérrez, L, Cleverley, K, Noy, S, Sheppard, O, Collins, T, Powell, C, Sarell, C J, Rickman, M, Choong, X, Tosh, J L, Siganporia, C, Whittaker, H T, Stewart, F, Szaruga, M, Murphy, M P, Blennow, K, De Strooper, B, Zetterberg, H, Bannerman, D, Holtzman, D M, Tybulewicz, V L J, Fisher, E M C, Strydom, A, Fisher, E, Nizetic, D, Hardy, J, Tybulewicz, V & Karmiloff-smith, A 2018, ' Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP ', Brain, vol. 141, no. 8, pp. 2457-2474 . https://doi.org/10.1093/brain/awy159

Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer’s disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid p

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https://kclpure.kcl.ac.uk/ws/files/104625419/Trisomy_of_human_chromosome_WISEMAN_Publishedonline26June2018_GOLD_VoR_CC_BY_.pdf